Monoclonal antibodies to common epitopes of the human αβ T-cell receptor preferentially activate CD45RA+ T-cells

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

The isolation and characterization of the human suppressor inducer T cell subset.

1985 • 860 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Human naive and memory T cells

1988 • 793 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.

1980 • 525 citations

Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.

1986 • 515 citations

Polymorphism in mitogenic effect of IgG1 monoclonal antibodies against T3 antigen on human T cells

1983 • 333 citations

Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation

1988 • 281 citations

Differential activation requirements for virgin and memory T cells.

1988 • 271 citations

Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3.

1987 • 188 citations

The Human T Cell Receptor: Analysis with Cytotoxic T Cell Clones

1983 • 163 citations

T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells.

1985 • 147 citations

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation.

1986 • 139 citations

Phenotypic changes associated with activation of CD45RA+ and CD45RO+ T cells.

1990 • 127 citations

Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor‐mediated activation

1989 • 124 citations

Hyporesponsiveness of “naive” (CD45RA⁺) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

1990 • 118 citations

Two subsets of human CD4⁺T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon‐γ can be defined by the Leu‐18 and UCHLl monoclonal antibodies

1988 • 94 citations

Investigation of early T cell activation: Analysis of the effect of specific antigen, interleukin 2 and monoclonal antibodies on intracellular free calcium concentration

1985 • 88 citations

T cell activation by anti‐T3 antibodies: Comparison of IgG₁ and IgG_2b switch variants and direct evidence for accessory function of macrophage Fc receptors

1986 • 76 citations

Immobilized anti-CD3 monoclonal antibodies induce accessory cell-independent lymphokine production, proliferation and helper activity in human T lymphocytes.

1989 • 63 citations

BMA031, a monoclonal antibody suited to identify the T-cell receptor αβ/CD3 complex on viable human T lymphocytes in normal and disease states

1990 • 40 citations

T cell activation by monoclonal antibodies directed to different epitopes on the human T cell receptor/CD3 complex: Evidence for two different modes of activation

1989 • 33 citations

Early events during primary activation of T cells: antigen receptor cross‐linking and interleukin 1 initiate proliferative response of human T cells

1985 • 32 citations

Differential effects of cytokines on proliferative response of human CD4+ T lymphocyte subsets stimulated via T cell receptor-CD3 complex.

1990 • 23 citations

Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4+CD29+CD45R- memory T lymphocytes.

1989 • 18 citations

Different Activation States of Human Lymphocytes after Antibody‐Mediated Stimulation via CD3 and the α/β T‐Cell Receptor

1990 • 6 citations