Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis

1981 • 1,768 citations

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

1993 • 660 citations

Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the national cancer institute‐sponsored working group

1988 • 415 citations

Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome.

1996 • 294 citations

Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance.

1996 • 278 citations

Spontaneous programmed death (apoptosis) of B‐chronic lymphocytic leukaemia cells following their culture in vitro

1989 • 260 citations

REGULATION OF CLINICAL CHEMORESISTANCE BY bcl‐2 AND BAX ONCOPROTEINS IN B‐CELL CHRONIC LYMPHOCYTIC LEUKAEMIA

1996 • 133 citations

Bcl-2 family proteins: regulators of chemoresistance in cancer

1995 • 89 citations

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

1993 • 66 citations

Chlorambucil induced apoptosis in chronic lymphocytic leukemia (CLL) and its relationship to clinical efficacy.

1994 • 49 citations

Defective Apoptosis due to Bcl-2 Overexpression May Explain Why B-CLL Cells Accumulate in G0

1995 • 32 citations

Apoptotic Cell Death in Chronic Lymphocytic Leukemia

1993 • 23 citations