Genetics of Colitis Susceptibility in IL-10-Deficient Mice: Backcross versus F2 Results Contrasted by Principal Component Analysis

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

1989 • 5,285 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Empirical threshold values for quantitative trait mapping.

1994 • 4,967 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

1998 • 1,451 citations

Computer-Aided Multivariate Analysis

1996 • 1,393 citations

Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

2001 • 1,331 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

Mapping of a susceptibility locus for Crohn's disease on chromosome 16

1996 • 961 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

2001 • 789 citations

Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice

1999 • 771 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Two stage genome–wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12

1996 • 713 citations

A Statistical Framework for Quantitative Trait Mapping

2001 • 632 citations

Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides

2001 • 534 citations

Genomewide Search in Canadian Families with Inflammatory Bowel Disease Reveals Two Novel Susceptibility Loci

2000 • 508 citations

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

2000 • 455 citations

Helicobacter hepaticusTriggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

1998 • 449 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelA

2000 • 397 citations

Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases.

1997 • 397 citations

Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis

1998 • 389 citations

A Genomewide Analysis Provides Evidence for Novel Linkages in Inflammatory Bowel Disease in a Large European Cohort

1999 • 386 citations

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1

1998 • 386 citations

Role of NF-κB in immune and inflammatory responses in the gut

1998 • 335 citations

Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.

1996 • 243 citations

Linkage of Inflammatory Bowel Disease to Human Chromosome 6p

1999 • 234 citations

A Genome-Wide Search Identifies Potential New Susceptibility Loci for Crohnʼs Disease

1999 • 211 citations

Concordance of Murine Quantitative Trait Loci for Salt-Induced Hypertension with Rat and Human Loci

2001 • 200 citations

High-Density Genome Scan in Crohn Disease Shows Confirmed Linkage to Chromosome 14q11-12

2000 • 196 citations

Loss of transforming growth factor β signalling in the intestine contributes to tissue injury in inflammatory bowel disease

2001 • 187 citations

Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16

1998 • 181 citations

FELASA recommendations for the health monitoring of mouse, rat, hamster, gerbil, guineapig and rabbit experimental units: Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Animal Health accepted by the FELASA Board of Management, November 1995

1996 • 172 citations

Linkage and Association between Inflammatory Bowel Disease and a Locus on Chromosome 12

1998 • 151 citations

Pleiotropic QTL Analysis

1998 • 149 citations

American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12

1998 • 142 citations

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

2000 • 121 citations

Helicobacter hepaticusDoes Not Induce or Potentiate Colitis in Interleukin-10-Deficient Mice

2000 • 119 citations

Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

1998 • 113 citations

A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice

2001 • 112 citations

A Novel Urease-Negative Helicobacter Species Associated with Colitis and Typhlitis in IL-10-Deficient Mice

1999 • 111 citations

Genetic Analysis of Susceptibility to Dextran Sulfate Sodium-Induced Colitis in Mice

1999 • 104 citations

Application of a canonical transformation to detection of quantitative trait loci with the aid of genetic markers in a multi-trait experiment

1996 • 103 citations

Chronic Colitis in IL-10^-/-Mice: Insufficient Counter Regulation of a Th1 Response

2000 • 81 citations

Linkage and linkage disequilibrium in chromosome band 1p36 in American Chaldeans with inflammatory bowel disease

2000 • 78 citations

Heritable susceptibility for colitis in mice induced by IL-10 deficiency

2000 • 76 citations

A genome-wide search identifies potential new susceptibility loci for Crohn's disease

2007 • 44 citations

Mapping quantitative trait loci for principal components of bone measurements and osteochondrosis scores in a wild boar × Large White intercross

2000 • 42 citations

Genetics of inflammatory bowel disease

2007 • 31 citations

Repression of transforming-growth-factor-β-mediated transcription by nuclear factor κB

2000 • 23 citations

Genetics of inflammatory bowel disease: from bench to bedside?

2001 • 16 citations