Influence of the Severity of Myocardial Ischemia on the Intensity of Ascorbyl Free Radical Release and on Postischemic Recovery during Reperfusion

The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate

1993 • 2,350 citations

THE DETERMINATION OF ASCORBIC ACID IN WHOLE BLOOD AND URINE THROUGH THE 2,4-DINITROPHENYLHYDRAZINE DERIVATIVE OF DEHYDROASCORBIC ACID

1943 • 1,810 citations

Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid

1996 • 861 citations

Transition metals as catalysts of “autoxidation” reactions

1990 • 721 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals

1988 • 507 citations

Ascorbic Acid: Chemistry, Metabolism, and Uses

1982 • 453 citations

Measurement and characterization of postischemic free radical generation in the isolated perfused heart

1989 • 383 citations

Ascorbate free radical as a marker of oxidative stress: An EPR study

1993 • 360 citations

Identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone DMPO

1987 • 357 citations

Reperfusion induced injury: manifestations, mechanisms, and clinical relevance

1992 • 326 citations

Oxygen-derived free radicals and myocardial reperfusion injury: An overview

1991 • 303 citations

Interaction of vitamin C and vitamin E during free radical stress in plasma: An ESR study

1993 • 243 citations

Electron spin resonance spectra of radical intermediates in the oxidation of ascorbic acid and related substances

1972 • 240 citations

Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism.

1994 • 215 citations

Copper and iron are mobilized following myocardial ischemia: possible predictive criteria for tissue injury.

1993 • 206 citations

Chemistry of Ascorbic Acid Radicals

1982 • 202 citations

Ascorbyl radical formation in patients with sepsis: Effect of ascorbate loading

1996 • 197 citations

Free radicals and ischemic tissue injury

1990 • 187 citations

Free radicals and reperfusion-induced arrhythmias: protection by spin trap agent PBN in the rat heart.

1987 • 179 citations

Antioxidant Potential of Anaerobic Human Plasma: Role of Serum Albumin and Thiols as Scavengers of Carbon Radicals

1994 • 177 citations

Ascorbate Autoxidation in the Presence of Iron and Copper Chelates

1986 • 172 citations

Hyperbaric Oxygen Therapy Increases Free Radical Levels in the Blood of Humans

1993 • 157 citations

The reaction of ascorbic acid with different heme iron redox states of myoglobin

1993 • 114 citations

Magnesium-deficiency potentiates free radical production associated with postischemic injury to rat hearts: Vitamin E affords protection

1994 • 91 citations

Ascorbate Oxidation: UV Absorbance of Ascorbate and ESR Spectroscopy of the Ascorbyl Radical as Assays for Iron

1990 • 90 citations

Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart. Evidence that complement activation is required for neutrophil-mediated reperfusion injury.

1993 • 90 citations

Malondialdehyde production and ascorbate decrease are associated to the reperfusion of the isolated postischemic rat heart

1992 • 86 citations

Ascorbyl radical as natural indicator of oxidative stress: quantitative regularities

1994 • 82 citations

Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts

1990 • 78 citations

Iron-induced ascorbate oxidation in plasma as monitored by ascorbate free radical formation. No spin-trapping evidence for the hydroxyl radical in iron-overloaded plasma

1992 • 75 citations

Ascorbyl free radical: A noninvasive marker of oxidative stress in human open-heart surgery

1994 • 73 citations

Reperfusion-Induced Arrhythmias and Free Radicals

1987 • 71 citations

Cobalt(II) and Nickel(II) Ions as Promoters of Free Radicals in Vivo: Detected Directly Using Electron Spin Resonance Spectrometry in Circulating Blood in Rats

1993 • 71 citations

Ascorbyl free radical as a reliable indicator of free‐radical‐mediated myocardial ischemic and post‐ischemic injury

1990 • 68 citations

Vasodilatory and toxic effects of spin traps on aerobic cardiac function☆

1993 • 64 citations

Detection of ferryl myoglobin in the isolated ischemic rat heart

1990 • 64 citations

Evaluation of free radical and lipid peroxide formation during global ischemia and reperfusion in isolated perfused rat heart

1988 • 62 citations

Ascorbyl free radical as a real-time marker of free radical generation in briefly ischemic and reperfused hearts. An electron paramagnetic resonance study.

1994 • 59 citations

Real‐time continuous‐flow spin trapping of hydroxyl free radical in the ischemic and post‐ischemic myocardium

1989 • 54 citations

Optimal EPR detection of weak nitroxide spin adduct and ascorbyl free radical signals

1992 • 53 citations

DMPO and reperfusion injury: Arrhythmia, heart function, electron spin resonance, and nuclear magnetic resonance studies in isolated working guinea pig hearts

1990 • 46 citations

Is oxidative stress primarily involved in reperfusion injury of the ischemic heart?

1991 • 45 citations

Relative time-profiles for free radical trapping, coronary flow, enzyme leakage, arrhythmias, and function during myocardial reperfusion

1994 • 41 citations

The catalytic activity of iron in synovial fluid as monitored by the ascorbate free radical

1990 • 41 citations

Inverse relationship between ESR spin trapping of oxyradicals and degree of functional recovery during myocardial reperfusion in isolated working rat heart

1990 • 41 citations

Evolution of free radical formation during low-flow ischemia and reperfusion in isolated rat heart

1990 • 40 citations

Interaction of vitamin E and ascorbic acid (review).

1989 • 35 citations

Direct detection of circulating free radicals in the rats using electron spin resonance spectrometry

1992 • 27 citations

Effects of the spin trap α-phenyl n-tert-butyl nitrone on myocardial function and flow: A dose-response study in the open-chest dog and in the isolated rat heart

1993 • 26 citations

Ascorbate radical levels in human sera and rat plasma intoxicated with paraquat and diquat

1993 • 26 citations

Direct Detection of Ascorbyl Radical in Experimental Brain Injury: Microdialysis and an Electron Spin Resonance Spectroscopic Study

1995 • 19 citations

Structure of ascorbic acid and its biological function. I. ESR determination of the ascorbyl radical in biological samples and in model systems.

1984 • 17 citations

Fe2+/vitamin C — An appropriate in vitro model system to initiate lipid peroxidation

1996 • 17 citations

Structure of ascorbic acid and its biological function

1983 • 16 citations

[14] Electron spin resonance assay of ascorbate free radicals in Vivo

1994 • 10 citations

Detection of an Increase in Ascorbate Radical in an Irradiated Experimental Tumour System Using ESR

1995 • 6 citations