Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid‐like fibrils

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

[32] GOR method for predicting protein secondary structure from amino acid sequence

1996 • 1,239 citations

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T

1989 • 1,133 citations

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

1987 • 957 citations

Trifluoroethanol and colleagues: cosolvents come of age. Recent studies with peptides and proteins

1998 • 826 citations

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

1990 • 782 citations

An algorithm for protein secondary structure prediction based on class prediction

1987 • 348 citations

Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in Vitro

1999 • 346 citations

ISLET AMYLOID FORMED FROM DIABETES-ASSOCIATED PEPTIDE MAY BE PATHOGENIC IN TYPE-2 DIABETES

1987 • 342 citations

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

1996 • 334 citations

SOPM: a self-optimized method for protein secondary structure prediction

1994 • 329 citations

Cooperative α‐helix formation of β‐lactoglobulin and melittin induced by hexafluoroisopropanol

1997 • 235 citations

Effects of Sequential Proline Substitutions on Amyloid Formation by Human Amylin_20-29

1999 • 195 citations

A model for the interaction of trifluoroethanol with peptides and proteins

1996 • 192 citations

The Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease

1992 • 182 citations

Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species

1989 • 176 citations

The molecular basis of amyloidosis

1997 • 165 citations

Improvements in a secondary structure prediction method based on a search for local sequence homologies and its use as a model building tool

1988 • 119 citations

Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide

1998 • 102 citations

Syntheses, structures and anorectic effects of human and rat amylin

1991 • 77 citations

B Cell Granule Peptides Affect Human Islet Amyloid Polypeptide (IAPP) Fibril Formationin Vitro

1997 • 76 citations

A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation

1998 • 67 citations

β-Structure in Human Amylin and 2 Designer β-Peptides: CD and NMR Spectroscopic Comparisons Suggest Soluble β-Oligomers and the Absence of Significant Populations of β-Strand Dimers

1994 • 49 citations

2,2,2-Trifluoroethanol Induces Helical Conformation in an All β-Sheet Protein

1996 • 47 citations

Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin

1991 • 43 citations

Promotion of β-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidylcholine

1992 • 39 citations

Molecular model-building of amylin and α-calcitonin gene-related polypeptide hormones using a combination of knowledge sources

1991 • 15 citations