Feasibility of reversing benzodiazepine tolerance with flumazenil

Selective antagonists of benzodiazepines

1981 • 1,235 citations

IN-VIVO DEMONSTRATION OF REDUCED BENZODIAZEPINE RECEPTOR BINDING IN HUMAN EPILEPTIC FOCI

1988 • 361 citations

Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity

1984 • 279 citations

Precipitated Withdrawal by a Benzodiazepine Receptor Antagonist (Ro 15-1788) After 7 Days of Diazepam

1982 • 154 citations

Audiogenic seizures in DBA/2 mice discriminate sensitively between low efficacy benzodazepine receptor agonists and inverse agonists

1983 • 147 citations

Automated blood sampling systems for positron emission tomography

1988 • 144 citations

Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions.

1987 • 91 citations

Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788

1983 • 84 citations

11C-labelling of Ro 15-1788 in two different positions, and also 11C-labelling of its main metabolite Ro 15-3890, for PET studies of benzodiazepine receptors

1988 • 81 citations

Time course for development of anticonvulsant tolerance and GABAergic subsensitivity after chronic diazepam

1987 • 65 citations

Spontaneous and Ro 15-1788-induced reversal of subsensitivity to GABA following chronic benzodiapines

1985 • 61 citations

The Anticonvulsant Effect of the Benzodiazepine Antagonist, Ro 15–1788: An EEG Study in 4 Cases

1984 • 58 citations

A benzodiazepine antagonist is an anticonvulsant in an animal model for limbic epilepsy

1983 • 57 citations

Rapid induction of lorazepam dependence and reversal with flumazenil

1988 • 54 citations

Benzodiazepine receptors': Correlation with pharmacological responses in living animals

1982 • 53 citations

Detection of benzodiazepine receptor occupancy in the human brain by positron emission tomography

1989 • 50 citations

Neurophysiological, genetic and biochemical nature of the epileptic diathesis.

1982 • 40 citations

Partial agonists of the benzodiazepine receptor: from animal data to results in patients.

1988 • 37 citations

BASIC computer program to summarize data using nonparametric and parametric statistics including Anderson-Darling test for normality

1988 • 34 citations

Cerebral uptake of ¹¹C—Ro 15—1788 and its acid metabolite ¹¹C—Ro 15—3890; PET study in healthy volunteers

1989 • 30 citations

Metabolism of the benzodiazepine antagonist ¹¹C‐Ro 15‐1788 after intravenous administration in man

1989 • 25 citations

RO 15–1788 A BENZODIAZEPINE ANTAGONIST IN THE TREATMENT OF 34 INTOXICATED PATIENTS

1985 • 23 citations

In vivo binding of (3H) Ro 15-1788 in mice: Comparison with the in vivo binding of (3H) flunitrazepam

1988 • 20 citations

Patch-clamp analysis of GABA- and glycine-gated chloride channels.

1988 • 7 citations

Classification of epilepsies

1985 • 4 citations