Phosphorylation of Both Serine Residues in Cardiac Troponin I Is Required to Decrease the Ca2+ Affinity of Cardiac Troponin C

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

1987 • 529 citations

Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart

1976 • 388 citations

The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin.

1982 • 351 citations

[22] Preparation of troponin and its subnits

1982 • 345 citations

Cardiac Troponin I Phosphorylation Increases the Rate of Cardiac Muscle Relaxation

1995 • 314 citations

Effect of rigor and cycling cross-bridges on the structure of troponin C and on the Ca2+ affinity of the Ca2+-specific regulatory sites in skinned rabbit psoas fibers.

1987 • 227 citations

Structural and regulatory functions of the NH2- and COOH-terminal regions of skeletal muscle troponin I.

1994 • 213 citations

Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts

1988 • 196 citations

Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart

1976 • 192 citations

Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase.

1993 • 178 citations

A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca2+ Regulation of Muscle Contraction

1995 • 169 citations

Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins.

1989 • 126 citations

Relaxing and inotropic effects of cyclic AMP on skinned cardiac cells

1975 • 113 citations

Molecular cloning of rat cardiac troponin I and analysis of troponin I isoform expression in developing rat heart

1991 • 109 citations

Effects of phosphorylation of troponin I and C protein on isometric tension and velocity of unloaded shortening in skinned single cardiac myocytes from rats.

1994 • 88 citations

NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex.

1994 • 84 citations

Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal peptide in myofilament activation.

1994 • 80 citations

Amino acid sequence of bovine cardiac troponin I

1988 • 78 citations

A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I

1990 • 74 citations

Isolation, expression, and mutation of a rabbit skeletal muscle cDNA clone for troponin I. The role of the NH2 terminus of fast skeletal muscle troponin I in its biological activity.

1992 • 73 citations

Cardiac troponin I, isolated from‐bovine heart, contains two adjacent phosphoserines

1988 • 73 citations

Phosphorylation of C-protein in intact amphibian cardiac muscle. Correlation between 32P incorporation and twitch relaxation.

1984 • 68 citations

Sites phosphorylated in bovine cardiac troponin T and I

1990 • 60 citations

Troponin replacement in permeabilized cardiac muscle Reversible extraction of troponin I by incubation with vanadate

1992 • 58 citations

Ordered phosphorylation of a duplicated minimal recognition motif for cAMP‐dependent protein kinase present in cardiac troponin I

1992 • 51 citations

Phosphorylation of a bovine cardiac actin complex

1979 • 28 citations

Characterization of the cardiac troponin I phosphorylation domain by 31P nuclear magnetic resonance spectroscopy

1993 • 26 citations