Free energy landscape for protein folding kinetics: Intermediates, traps, and multiple pathways in theory and lattice model simulations

Proteins: Structures and Molecular Properties

1986 • 2,694 citations

Spin glasses and the statistical mechanics of protein folding.

1987 • 1,608 citations

Protein Folding

1992 • 1,601 citations

Estimation of effective interresidue contact energies from protein crystal structures: quasi-chemical approximation

1985 • 1,570 citations

Random-energy model: An exactly solvable model of disordered systems

1981 • 1,294 citations

Intermediates and barrier crossing in a random energy model (with applications to protein folding)

1989 • 748 citations

Formation of a Molten Globule Intermediate Early in the Kinetic Folding Pathway of Apomyoglobin

1993 • 735 citations

The folding of hen lysozyme involves partially structured intermediates and multiple pathways

1992 • 719 citations

Kinetics of Protein Folding

1994 • 572 citations

Protein folding: Hypotheses and experiments

1987 • 544 citations

Engineering of stable and fast-folding sequences of model proteins.

1993 • 543 citations

The role of topological constraints in the kinetics of collapse of macromolecules

1988 • 414 citations

Proteins with selected sequences fold into unique native conformation

1994 • 395 citations

Kinetics and thermodynamics of folding in model proteins.

1993 • 371 citations

Formation of unique structure in polypeptide chains

1989 • 319 citations

Protein folding bottlenecks: A lattice Monte Carlo simulation

1991 • 296 citations

Theory of cooperative transitions in protein molecules. I. Why denaturation of globular protein is a first‐order phase transition

1989 • 288 citations

Implications of thermodynamics of protein folding for evolution of primary sequences

1990 • 279 citations

Folding kinetics of proteinlike heteropolymers

1994 • 263 citations

Enumeration of all compact conformations of copolymers with random sequence of links

1990 • 256 citations

Pulsed H/D-exchange studies of folding intermediates

1993 • 245 citations

A new approach to the design of stable proteins

1993 • 240 citations

Theory for protein mutability and biogenesis.

1990 • 236 citations

Conformations of folded proteins in restricted spaces

1990 • 231 citations

Noninteracting local‐structure model of folding and unfolding transition in globular proteins. I. Formulation

1981 • 224 citations

Early hydrogen-bonding events in the folding reaction of ubiquitin.

1992 • 220 citations

Biomolecules: Where the Physics of Complexity and Simplicity Meet

1994 • 217 citations

Detection and characterization of a folding intermediate in barnase by NMR

1990 • 212 citations

Mean-Field Model for Protein Folding

1988 • 187 citations

Analysis of Monte Carlo results on the kinetics of lattice polymer chains with excluded volume

1975 • 184 citations

Dynamic Monte Carlo simulations of a new lattice model of globular protein folding, structure and dynamics

1991 • 170 citations

Frozen states of a disordered globular heteropolymer

1989 • 144 citations

Energy landscapes and the collapse dynamics of homopolymers

1993 • 122 citations

Phase diagram of random copolymers

1993 • 119 citations

Folding kinetics of proteins and copolymers

1992 • 112 citations

Why are the same protein folds used to perform different functions?

1993 • 91 citations

Dynamic Monte Carlo simulations of globular protein folding/unfolding pathways

1990 • 87 citations

The Nonergodic (“Spin-Glass–Like”) Phase of Heteropolymer with Quenched Disordered Sequence of Links

1989 • 85 citations

Comparison of lattice Monte Carlo dynamics and Brownian dynamics folding pathways of α-helical hairpins

1991 • 76 citations

Ground state of random copolymers and the discrete random energy model

1993 • 75 citations

Monte Carlo studies of lattice-model polymer chains. III. Relaxation of Rouse coordinates

1973 • 71 citations

Relaxation to Equilibrium in the Random Energy Model

1989 • 58 citations

Phase diagram of a model protein derived by exhaustive enumeration of the conformations

1994 • 55 citations

Non-Exponential Relaxation Time Scales in Disordered Systems: An Application to Protein Dynamics

1994 • 11 citations