Differential Effects of Ca2+ Channel β1a and β2a Subunits on Complex Formation with α1S and on Current Expression in tsA201 Cells

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS

1995 • 941 citations

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

1989 • 922 citations

Restoration of excitation—contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA

1988 • 803 citations

Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit

1994 • 659 citations

Regions of the skeletal muscle dihydropyridine receptor critical for excitation–contraction coupling

1990 • 606 citations

Auxiliary subunits of voltage-gated ion channels

1994 • 561 citations

The role of Ca2+ ions in excitation-contraction coupling of skeletal muscle fibres

1995 • 540 citations

Crosstalk between G proteins and protein kinase C mediated by the calcium channel α1 subunit

1997 • 491 citations

Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle.

1987 • 468 citations

Molecular Basis for CA2+ Channel Diversity

1994 • 461 citations

Direct binding of G-protein βλ complex to voltage-dependent calcium channels

1997 • 441 citations

Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.

1992 • 416 citations

Primary Structure of the β Subunit of the DHP-Sensitive Calcium Channel from Skeletal Muscle

1989 • 371 citations

Induction of calcium currents by the expression of the α1-subunit of the dihydropyridine receptor from skeletal muscle

1989 • 297 citations

Acceleration of activation and inactivation by the β subunit of the skeletal muscle calcium channel

1991 • 291 citations

Normalization of current kinetics by interaction between the α1and β subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel

1991 • 286 citations

Roles of a Membrane-localized βSubunit in the Formation and Targeting of Functional L-type Ca2+ Channels

1995 • 269 citations

Potentiation by the β Subunit of the Ratio of the Ionic Current to the Charge Movement in the Cardiac Calcium Channel

1993 • 250 citations

Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel from rabbit skeletal muscle. Evidence for two distinct high molecular weight subunits.

1987 • 231 citations

Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle.

1996 • 213 citations

The amino terminus of a calcium channel β subunitsets rates of channel inactivation independently of the subunit's effect on activation

1994 • 191 citations

Identification of Palmitoylation Sites within the L-type Calcium Channel β2a Subunit and Effects on Channel Function

1996 • 189 citations

A Xenopus oocyte β subunit: Evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit

1997 • 181 citations

Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels.

1990 • 171 citations

Ca2+ current enhancement by alpha 2/delta and beta subunits in Xenopus oocytes: contribution of changes in channel gating and alpha 1 protein level.

1995 • 154 citations

The mechanical hypothesis of excitation—contraction (EC) coupling in skeletal muscle

1991 • 151 citations

Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations.

1987 • 150 citations

Importance of the Different |β Subunits in the Membrane Expression of the α1A and α2 Calcium Channel Subunits: Studies Using a Depolarization‐sensitive α1A Antibody

1997 • 145 citations

Molecular Determinants of High Affinity Phenylalkylamine Block of L-type Calcium Channels

1995 • 136 citations

Endogenous calcium channels in human embryonic kidney (HEK293) cells

1996 • 125 citations

Subcellular distribution of the 1,4-dihydropyridine receptor in rabbit skeletal muscle in situ: an immunofluorescence and immunocolloidal gold-labeling study.

1989 • 117 citations

Inhibition of the interaction of G protein G(o) with calcium channels by the calcium channel beta‐subunit in rat neurones.

1995 • 116 citations

β Subunit Heterogeneity in Neuronal L-type Ca2+Channels

1997 • 111 citations

Triad formation: organization and function of the sarcoplasmic reticulum calcium release channel and triadin in normal and dysgenic muscle in vitro.

1993 • 109 citations

Reduced Ca2+ current, charge movement, and absence of Ca2+ transients in skeletal muscle deficient in dihydropyridine receptor beta 1 subunit

1996 • 98 citations

Association of Native Ca2+ Channel β Subunits with the α1 Subunit Interaction Domain

1995 • 97 citations

The beta subunit increases Ca2+ currents and gating charge movements of human cardiac L-type Ca2+ channels

1996 • 92 citations

Identification of critical amino acids involved in α₁‐β interaction in voltage‐dependent Ca²⁺ channels

1996 • 91 citations

Modulation of the Cloned Skeletal Muscle L-Type Ca²⁺Channel by Anchored cAMP-Dependent Protein Kinase

1997 • 90 citations

Molecular organization of transverse tubule/sarcoplasmic reticulum junctions during development of excitation-contraction coupling in skeletal muscle.

1994 • 82 citations

Localization of the α1 and α2 subunits of the dihydropyridine receptor and ankyrin in skeletal muscle triads

1990 • 81 citations

Identification of a second region of the beta-subunit involved in regulation of calcium channel inactivation

1996 • 65 citations

Calcium channels: The β‐subunit increases the affinity of dihydropyridine and Ca²⁺ binding sites of the α₁‐subunit

1994 • 58 citations

Dihydropyridine receptor alpha subunits in normal and dysgenic muscle in vitro: expression of alpha 1 is required for proper targeting and distribution of alpha 2.

1991 • 56 citations

Single-Channel Analysis of a Cloned Human Heart L-Type Ca2+ Channel α1 Subunit and the Effects of a Cardiac β Subunit

1993 • 49 citations

Functional Expression and Characterization of Skeletal Muscle Dihydropyridine Receptors in Xenopus Oocytes

1997 • 31 citations

The beta subunit controls the gating and dihydropyridine sensitivity of the skeletal muscle Ca2+ channel

1992 • 25 citations