Melatonin's Role as an Anticonvulsant and Neuronal Protector: Experimental and Clinical Evidence

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

1991 • 2,190 citations

Light Suppresses Melatonin Secretion in Humans

1980 • 1,873 citations

Melatonin : a potent, endogenous hydroxyl radical scavenger

1993 • 1,673 citations

NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices

1989 • 912 citations

A review of the evidence supporting melatonin's role as an antioxidant

1995 • 827 citations

Ionic Mechanisms of Neuronal Excitation by Inhibitory GABA _A Receptors

1995 • 800 citations

Melatonin: A peroxyl radical scavenger more effective than vitamin E

1994 • 741 citations

Light therapy for Seasonal Affective Disorder A review of efficacy

1989 • 534 citations

Oxidative stress: Free radical production in neural degeneration

1994 • 483 citations

On the antioxidant effects of ascorbic acid and glutathione

1992 • 382 citations

On the effect of melatonin upon human brain. Its possible therapeutic implications

1971 • 320 citations

Quinolinic acid and other kynurenines in the central nervous system

1985 • 311 citations

Melatonin. A Mammalian Pineal Hormone*

1981 • 284 citations

Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors

1990 • 256 citations

Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole

1994 • 249 citations

MELATONIN

1988 • 224 citations

Melatonin reduces nitric oxide synthase activity in rat hypothalamus

1996 • 212 citations

Binding of 3H-melatonin to calmodulin

1993 • 207 citations

Functional Pleiotropy of the Neurohormone Melatonin: Antioxidant Protection and Neuroendocrine Regulation

1995 • 205 citations

Melatonin is protective against MPTP-induced striatal and hippocampal lesions

1996 • 200 citations

The pineal gland: anatomy, physiology, and clinical significance

1985 • 197 citations

Pineal gland interface between the photoperiodic environment and the endocrine system

1991 • 190 citations

TIME OF DAY IN RELATION TO CONVULSIONS IN EPILEPSY.

1929 • 181 citations

Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.

1986 • 174 citations

Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: Two years' experience

1997 • 174 citations

Melatonin: effects on brain function.

1974 • 169 citations

Serum Hormones in Male Epileptic Patients Receiving Anticonvulsant Medication

1990 • 168 citations

Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors

1988 • 163 citations

Minireview: Cell protective role of melatonin in the brain

1995 • 147 citations

γ‐Hydroxybutyrate Model of Generalized Absence Seizures: Further Characterization and Comparison with Other Absence Models

1988 • 146 citations

The suprachiasmatic nucleus and the organization of a circadian system

1982 • 133 citations

Metabolic Modification of Parkinson's Disease and of Chronic Manganese Poisoning

1971 • 118 citations

Epileptic but Not Psychogenic Seizures Are Accompanied by Simultaneous Elevation of Serum Pituitary Hormones and Cortisol Levels

1989 • 117 citations

The anticonvulsant properties of melatonin on kindled seizures in rats

1981 • 113 citations

Sleep Induction by Intranasal Application of Melatonin

1981 • 110 citations

Modulation of seizure susceptibility in the mouse by the strychnine‐insensitive glycine recognition site of the NMDA receptor/ion channel complex

1990 • 109 citations

Melatonin in rat pineal gland and serum; rapid parallel decline after light exposure at night

1978 • 98 citations

Changes in Gamma-Aminobutyric Acid High Affinity Binding to Cerebral Cortex Membranes after Pinealectomy or Melatonin Administration to Rats

1986 • 94 citations

Circadian rhythmicity in absence epilepsy in rats

1988 • 92 citations

Effects of chronic melatonin administration on GABA and diazepam binding in rat brain

1987 • 85 citations

Diurnal Variations of Benzodiazepine Binding in Rat Cerebral Cortex: Disruption by Pinealectomy

1986 • 84 citations

Effects of melatonin and propranolol on sleep of the rat

1980 • 83 citations

A hypothesis to integrate partial seizures of temporal lobe origin and reproductive endocrine disorders

1989 • 82 citations

The circadian distribution of interictal epileptiform EEG activity

1984 • 78 citations

Prophylactic Actions of Melatonin in Oxidative Neurotoxicity

1997 • 76 citations

Melatonin and Parkinsonism

1972 • 71 citations

Epileptogenic action of intraventricularly injected antimelatonin antibody

1977 • 70 citations

Melatonin lowers excitability of guinea pig hippocampal neurons in vitro

1985 • 65 citations

The GABA-benzodiazepine interaction fifteen years later

1990 • 65 citations

Antiepileptic Effects of Melatonin in the Pinealectomized Mongolian Gerbil

1980 • 57 citations

Circadian rhythms

1993 • 56 citations

Nocturnal enhancement of plasma melatonin could be suppressed by benzodiazepines in humans.

1986 • 55 citations

Melatonin in serum and urine in patients with idiopathic pain syndromes

1987 • 53 citations

Melatonin-dopamine interaction in the striatal projection area of sensorimotor cortex in the rat

1996 • 49 citations

Day-night variations in melatonin secretion by the pineal gland during febrile and epileptic convulsions in children

1994 • 46 citations

Seasonal variations in the incidence of photoparoxysmal response to stimulation among photosensitive epileptic patients: evidence from repeated EEG recordings.

1988 • 45 citations

Seasonal and sex influences on ketamine-induced analgesia and catalepsy in the rat; a possible role for melatonin

1986 • 43 citations

Characterization of Pinealectomy Induced Convulsions in the Mongolian Gerbil (Meriones unguiculatus)

1978 • 42 citations

Attempts to characterize the convulsive response of parathyroidectomized rats to pineal gland removal

1972 • 40 citations

Some reflections on the phylogeny and function of the pineal

1989 • 34 citations

Effects of febrile and epileptic convulsions on daily variations in plasma melatonin concentration in children

1994 • 33 citations

Menstrual cycle effects on the metabolism of tryptophan loads

1989 • 33 citations

Muscular spasms and death in thyroparathyroidectomized rats subjected to pinealectomy

1972 • 31 citations

Hormonal Considerations in Women With Seizures

1988 • 29 citations

Pineal modulation of the rat caudate‐putamen spontaneous neuronal activity: Roles of melatonin and vasotocin

1993 • 29 citations

Epileptic discharges induced by intermittent light stimulation in photosensitive baboons: a current source density study

1988 • 28 citations

Photic epilepsy problems raised in man and animals

1987 • 27 citations

Hippocampal evoked potentials and convulsive activity after electrolytic lesions of the pineal body, in chronic experiments on rabbits.

1965 • 27 citations

Intracerebroventricular injection of naloxone blocks melatonin-dependent brain [3H]flunitrazepam binding

1993 • 26 citations

Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures

1997 • 26 citations

Novel anticonvulsant action of chronic melatonin in gerbils

1992 • 26 citations

Biorhythms and Epilepsy

1986 • 23 citations

Biorhythms and epilepsy

1986 • 23 citations

Effects of kynurenic acid on amygdaloid kindling in the rat

1988 • 23 citations

Introdução ao estudo da cronobiologia

1988 • 23 citations

The Mammalian Pineal Gland as an End Organ of the Visual System11Work by the author was supported by grants from the National Science Foundation and from the National Institutes of Health.

1993 • 22 citations

Modulation by pineal gland of ouabain high-affinity binding sites in rat cerebral cortex

1992 • 22 citations

Coexistence of central and peripheral benzodiazepine binding sites in the human pineal gland

1987 • 21 citations

Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles

1986 • 20 citations

Pineal-Brain Relationships

2008 • 19 citations

Influence of the Behaviorally Active Peptides ACTH<sub>1–10</sub>, and ACTH<sub>4–10</sub> on the Melatonin Modulation of <sup>3</sup>H-Flunitrazepam Receptor Binding in the Rat Cerebral Cortex

1994 • 15 citations

The effects of constant light on EEG and seizure activity in the epileptic baboon

1982 • 13 citations

Melatonin counteracts pinealectomy-dependent decreases in rat brain [3H]flunitrazepam binding through an opioid mechanism

1993 • 12 citations

Can "Resetting" Hormonal Rhythms Treat Illness?

1995 • 11 citations

Seasonal variations of electroshock seizure susceptibility in the rat.

1971 • 11 citations

Could supplementary dietary tryptophan and taurine prevent epileptic seizures?

1985 • 11 citations

Melatonin mediation in sedative effect of serotonin in goldfish

1979 • 11 citations

Characterization of ouabain high-affinity binding to rat cerebral cortex. Modulation by melatonin

1992 • 10 citations

The Circadian Rhythm of Typical Absence Seizures - The Frequency and Duration of Paroxysmal Discharges

1990 • 6 citations

Effect of in vivo anticonvulsant drugs on pineal gland indole metabolism in organ culture

1986 • 6 citations

[The timing of crisis and day-night distribution of paroxysmal EEG activities: a study on 197 epileptic patients].

1987 • 6 citations

Epilepsy and photosensitivity.

1989 • 4 citations

Effect of anticonvulsant drugs in vitro on pineal gland indole metabolism in organ culture

1985 • 3 citations

Análisis de las variaciones circadianas de melatonina y degradación del triptofano tras una crisis convulsiva en la infancia

1994 • 2 citations