Hydroxylation of debrisoquine using perfused liver isolated from Sprague Dawley and DA rats: comparison with in-vivo results.

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

Cytochrome P-450 Monooxygenase Activities in Human and Rat Liver Microsomes

1981 • 173 citations

Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical Significance

1979 • 163 citations

Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detection

1977 • 155 citations

Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism

1984 • 150 citations

Animal modelling of human polymorphic drug oxidation—the metabolism of debrisoquine and phenacetin in rat inbred strains

1981 • 141 citations

Defective metabolism of metoprolol in poor hydroxylators of debrisoquine.

1982 • 125 citations

Effects of route of administration and blood flow on hepatic drug elimination.

1975 • 104 citations

Cytochrome P-450 as a determinant of sex difference of drug metabolism in the rat

1982 • 94 citations

Perfusion of isolated rat liver with a semisynthetic medium and control of liver function

1962 • 66 citations

Inherited Defects of Hepatic Drug Metabolism

1983 • 54 citations

Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat.

1985 • 52 citations

Phenotypic differences in expression of cytochrome P-450g but not its mRNA in outbred male Sprague-Dawley rats

1987 • 48 citations

Differential Effects of Hypoxia on the Disposition of Propranolol and Sodium Taurocholate by the Isolated Perfused Rat Liver

1984 • 46 citations

Comparative pharmacogenetics of sparteine and debrisoquine

1983 • 37 citations

[Drug hydroxylation disorders (debrisoquin type) in a random sample of the Swiss population].

1982 • 29 citations

Spectral binding studies of the polymorphically metabolized drugs debrisoquine, sparteine and phenformin by cytochrome P-450 of normal and hydroxylation deficient rat strains

1982 • 23 citations

Temperature Effects on Radiocolloid Uptake by the Isolated Rat Liver

1957 • 12 citations

Reductive Drug Metabolism in Isolated Perfused Rat Liver under Restricted Oxygen Supply

1978 • 11 citations

Liver perfusion technique using inexpensive nonbinding medium for first-pass metabolism studies of drugs

1979 • 9 citations

Relation between drug elimination kinetics in intact animals and isolated perfused liver systems: phenylbutazone

1970 • 5 citations

The sodium and bicarbonate dependence of bile secretion in the guinea-pig

1985 • 5 citations

Drug Metabolizing Function of Isolated Perfused Liver

1975 • 4 citations

Comparative effect of a series of hypolipidemic compounds oh the release of enzymes from isolated hepatocytes

1985 • 3 citations