WT1—more than a transcription factor?

WT-1 is required for early kidney development

1993 • 1,976 citations

Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome

1991 • 944 citations

The candidate Wilms' tumour gene is involved in genitourinary development

1990 • 884 citations

Pax-2 controls multiple steps of urogenital development

1995 • 865 citations

Donor splice-site mutations in WT1 are responsible for Frasier syndrome

1997 • 727 citations

Chromosomal Imbalance in the Aniridia-Wilms' Tumor Association: 11p Interstitial Deletion

1978 • 726 citations

Alternative splicing and genomic structure of the Wilms tumor gene WT1.

1991 • 628 citations

Wilms' Tumor 1 and Dax-1 Modulate the Orphan Nuclear Receptor SF-1 in Sex-Specific Gene Expression

1998 • 593 citations

Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence

1990 • 588 citations

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo

1993 • 582 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix

1997 • 529 citations

Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor.

1994 • 509 citations

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

1995 • 502 citations

Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms

1998 • 363 citations

Repression of Pax-2 by WT1 during normal kidney development

1995 • 265 citations

A Novel Repressor, par-4, Modulates Transcription and Growth Suppression Functions of the Wilms’ Tumor Suppressor WT1

1996 • 254 citations

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.

1995 • 247 citations

THE GENETICS OF WILMS’ TUMOR—A Case of Disrupted Development

1994 • 232 citations

RNA binding by the Wilms tumor suppressor zinc finger proteins.

1996 • 218 citations

The Wilms tumour gene WT1 is expressed in murine mesoderm–derived tissues and mutated in a human mesothelioma

1993 • 211 citations

RNA editing in the Wilms' tumor susceptibility gene, WT1.

1994 • 186 citations

Mutations in the Wilms' tumor gene WT1 in leukemias

1996 • 176 citations

WT1-mediated Transcriptional Activation Is Inhibited by Dominant Negative Mutant Proteins

1995 • 172 citations

The WT1 Wilms' tumor suppressor gene: How much do we really know?

1996 • 168 citations

Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.

1995 • 158 citations

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding

1998 • 152 citations

A Non-AUG Translational Initiation Event Generates Novel WT1 Isoforms

1996 • 148 citations

A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1.

1993 • 139 citations

Inductive Tissue Interactions, Cell Signaling, and the Control of Kidney Organogenesis

1997 • 137 citations

The Wilms' tumor suppressor gene WT1 is negatively autoregulated.

1994 • 133 citations

The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1).

1996 • 122 citations

The Wilms' Tumor 1 Gene: Oncogene or Tumor Suppressor Gene?

1998 • 121 citations

Induction of p21 by the Wilms' tumor suppressor gene WT1.

1997 • 119 citations

The evolution of WT1 sequence and expression pattern in the vertebrates.

1995 • 117 citations

An RNA recognition motif in Wilms' tumour protein (WT1) revealed by structural modelling

1996 • 116 citations

Antagonism of WT1 activity by protein self-association.

1995 • 108 citations

Regulation of WT1 by phosphorylation: inhibition of DNA binding, alteration of transcriptional activity and cellular translocation.

1996 • 104 citations

Sp1 Is a Critical Regulator of the Wilms' tumor-1 Gene

1997 • 103 citations

Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70

1998 • 95 citations

Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1.

1996 • 95 citations

Molecular Cloning of the cDNA and Chromosome Localization of the Gene for Human Ubiquitin-conjugating Enzyme 9

1996 • 92 citations

Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product

1998 • 86 citations

Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome?

1998 • 82 citations

PAX8-mediated activation of the wt1 tumor suppressor gene.

1996 • 69 citations

The desmoplastic small round cell tumor t(11;22) translocation produces EWS/WT1 isoforms with differing oncogenic properties

1998 • 68 citations

Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain

1997 • 57 citations

Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene product

1996 • 57 citations

Cellular Factors Binding to a Novel cis-Acting Element Mediate Steroid Hormone Responsiveness of Mouse Mammary Tumor Virus Promoter

1995 • 50 citations

E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells

1998 • 45 citations

Autoregulation of the human WT1 gene promoter

1994 • 41 citations

A Far Upstream Cis-element Is Required for Wilms' Tumor-1 (WT1) Gene Expression in Renal Cell Culture

1997 • 19 citations

The Krüppel-associated Box (KRAB)-Zinc Finger Protein Kid-1 and the Wilms' Tumor Protein WT1, Two Transcriptional Repressor Proteins, Bind to Heteroduplex DNA

1997 • 16 citations

Novel replication inhibitory function of the developmental regulator/transcription repressor protein WT1 encoded by the Wilms' tumor gene.

1994 • 11 citations

Analysis of possible WT1 RNA processing in primary Wilms tumors.

1996 • 10 citations