Clinical Pharmacokinetics of Theophylline

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

Rational Intravenous Doses of Theophylline

1973 • 666 citations

Pharmacokinetics of theophylline; Application to adjustment of the clinical dose of aminophylline

1972 • 507 citations

Theophylline-Induced Seizures in Adults

1975 • 426 citations

A STUDY OF THE METABOLISM OF THEOBROMINE, THEOPHYLLINE, AND CAFFEINE IN MAN

1957 • 304 citations

Therapeutic Drug Monitoring in Saliva

1978 • 300 citations

Clinical Experience With Theophylline

1976 • 271 citations

Evaluation of oral bronchodilator therapy in asthmatic children

1974 • 267 citations

Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man

1976 • 265 citations

Pharmacokinetic Aspects of Theophylline in Premature Newborns

1976 • 250 citations

Dosage of Theophylline in Bronchial Asthma

1975 • 243 citations

Pharmacokinetics of Theophylline in Children With Asthma

1976 • 239 citations

Effect of smoking on theophylline disposition

1976 • 228 citations

Prevention of Apnea and Bradycardia in Low-Birthweight Infants

1975 • 217 citations

Altered Hepatic Blood Flow and Drug Disposition1

1976 • 209 citations

An ultraviolet spectrophotometric method for the determination of theophylline and theobromine in blood and tissues.

1949 • 203 citations

Theophylline Disposition in Patients with Hepatic Cirrhosis

1977 • 192 citations

Pharmacokinetics of intravenous theophylline

1973 • 187 citations

Monitoring Serum Theophylline Levels

1978 • 183 citations

Inhibition of theophylline clearance by troleandomycin

1977 • 170 citations

Bronchodilator Effects of Terbutaline and Aminophylline Alone and in Combination in Asthmatic Patients

1978 • 163 citations

Dose-dependent kinetics of theophylline disposition in asthmatic children

1977 • 158 citations

Enhanced biotransformation of theophylline in marihuana and tobacco smokers

1978 • 158 citations

Theophylline metabolism by the rat liver microsomal system.

1976 • 155 citations

Theophylline kinetics in acute pulmonary edema

1977 • 155 citations

COMPARISON OF CROMOGLYCATE (CROMOLYN) AND THEOPHYLLINE IN CONTROLLING SYMPTOMS OF CHRONIC ASTHMA

1977 • 150 citations

Relationship between theophylline concentration in plasma and saliva of man

1974 • 149 citations

Role of tobacco smoking in pharmacokinetics

1978 • 146 citations

Pharmacokinetic analysis of the disposition of intravenous theophylline in young children

1976 • 145 citations

Pharmacokinetic analysis of the effect of the ophylline on pulmonary function in asthmatic children

1975 • 144 citations

Effect of charcoal‐broiled beef on antipyrine and theophylline metabolism

1978 • 142 citations

Theophylline disposition in acutely ill hospitalized patients. The effect of smoking, heart failure, severe airway obstruction, and pneumonia.

1978 • 141 citations

Pharmacokinetics of Theophylline in Hepatic Disease

1978 • 136 citations

Relationship of theophylline clearance to oral dosage in children with chronic asthma

1977 • 134 citations

Absolute bioavailability of oral theophylline

1977 • 130 citations

Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography.

1974 • 130 citations

Decreased theophylline half-life in cigarette smokers

1975 • 124 citations

Relationship of Serum Theophylline Concentration to Inhibition of Exercise-Induced Bronchospasm and Comparison With Cromolyn

1977 • 123 citations

Influence of diet and fluid on bioavailability of theophylline

1975 • 123 citations

The influence of cigarette smoking and sex on theophylline disposition.

1977 • 120 citations

Rapidly achieved plasma concentration plateaus, with observations on theophylline kinetics

1972 • 117 citations

Relationship of urinary metabolites of theophylline to serum theophylline levels

1976 • 116 citations

Oral theophylline dosage for the management of chronic asthma

1978 • 115 citations

Theophylline disposition in obesity

1978 • 110 citations

Intravenous Aminophylline Dosage

1976 • 108 citations

Intravenous Theophylline Therapy: Nomogram Guidelines

1977 • 102 citations

Interaction of ephedrine and theophylline

1975 • 101 citations

Pharmacologic effects of intravenously administered aminophylline in asthmatic children

1970 • 100 citations

Effect of Aminophylline on Urinary Excretion of Epinephrine and Norepinephrine in Man

1967 • 99 citations

Effect of phenobarbital on theophylline disposition

1978 • 98 citations

Theophylline pharmacokinetics in premature infants with apnea

1976 • 98 citations

Theophylline secretion into breast milk.

1976 • 98 citations

Theophylline bioavailability following oral administration of six sustained-release preparations.

1978 • 94 citations

Cardiovascular response to increasing theophylline concentrations

1977 • 86 citations

Gas-Chromatographic Determination of Theophylline in Human Serum and Saliva

1975 • 86 citations

Determination of theophylline in plasma ultrafiltrate by reversed phase high pressure liquid chromatography

1976 • 82 citations

THE MECHANISM OF ACTION OF AMINOPHYLLINE UPON CEREBRAL VASCULAR DISORDERS

1970 • 79 citations

More sensitive high-pressure liquid-chromatographic determiantion of theophylline in serum.

1976 • 76 citations

Hemodynamic Effects of Aminophylline in Cor Pulmonale

1966 • 76 citations

Rapid Analysis for Theophylline in Serum by Use of High-Pressure Cation-Exchange Chromatography

1975 • 74 citations

METABOLISM OF THEOPHYLLINE (1, 3-DIMETHYLXANTHINE) IN MAN

1952 • 71 citations

The supra-additive natriuretic effect addition of bendroflumethiazide and bumetanide in congestive heart failure

1975 • 70 citations

Theophylline for treatment of asthma

1978 • 70 citations

Effect of aminophylline on ventilatory responses in normal man.

1978 • 70 citations

GLC Determination of Theophylline in Biological Fluids

1974 • 69 citations

The Effect of Intracarotid Aminophylline Infusion on the Cerebral Circulation

1972 • 69 citations

Effects of theophylline on myocardial mechanics

1972 • 67 citations

Theophylline blood levels after oral, rectal and intravenous administration, and correlation with diuretic action.

1950 • 65 citations

Studies of the Development and Decay of the Human Frame

1968 • 64 citations

Renal Clearance of Theophylline in Man

1976 • 63 citations

Sustained-Release Theophylline Therapy for Chronic Childhood Asthma

1978 • 62 citations

Ultraviolet Spectrophotometry of Theophylline in Plasma in the Presence of Barbiturates

1975 • 61 citations

Hemodynamic Effects of Aminophylline in Chronic Obstructive Pulmonary Disease

1967 • 60 citations

Hemodialysis Clearance of Theophylline

1977 • 59 citations

Clinical Toxicity of Theophylline in Relation to Cigarette Smoking

1978 • 58 citations

Plasma Theophylline Concentrations Measured by High-Pressure Liquid Chromatography

1975 • 56 citations

A re-evaluation of parenteral aminophylline.

1973 • 55 citations

Intrapatient variability in theophylline kinetics

1977 • 55 citations

A rapid micromethod for measuring theophylline in serum by reverse-phase high-performance liquid chromatography

1977 • 53 citations

Gas-chromatographic micro-scale procedure for theophylline, with use of a nitrogen-sensitive detector.

1976 • 51 citations

AMINOPHYLLINE IN BRONCHIAL ASTHMA

1967 • 51 citations

Theophylline Concentrations in Asthmatic Patients

1977 • 48 citations

Effect of phenobarbital on the disposition of intravenous theophylline

1977 • 48 citations

Theophylline Toxicity due to Impaired Theophylline Degradation^1,2

1974 • 47 citations

Development of a radioimmunoassay for theophylline; Application to studies in premature infants

1977 • 47 citations

Variation in theophylline clearance rate with time in chronic childhood asthma

1977 • 46 citations

Serum theophylline analysis by high-pressure liquid chromatography.

1976 • 44 citations

Theophylline poisoning

1977 • 44 citations

High-pressure liquid chromatographic and spectrophotometric assays for theophylline in biological fluids.

1976 • 42 citations

The influence of dietary methylxanthines on the metabolism and pharmacokinetics of intravenously administered theophylline [proceedings]

1977 • 41 citations

System for clinical pharmacokinetic monitoring of theophylline therapy.

1976 • 41 citations

Kinetics of intravenous theophylline

1977 • 40 citations

Apparent Theophylline Half-Life Fluctuations During Treatment of Acute Left Ventricular Failure

1977 • 39 citations

Kinetics of Theophylline

1979 • 39 citations

A re-evaluation of parenteral aminophylline

1973 • 38 citations

The human metabolism of caffeine to theophylline.

1976 • 36 citations

Oral Aminophylline Therapy

1977 • 35 citations

Evaluation of therapeutic substances employed for the relief of bronchospasm.

1948 • 33 citations

Effect of theophylline of hepatic excretory function

1974 • 33 citations

Assessment of combined oral theophylline and inhaled beta‐adrenoceptor agonist bronchodilator therapy.

1978 • 33 citations

EVALUATION OF THERAPEUTIC SUBSTANCES EMPLOYED FOR THE RELIEF OF BRONCHOSPASM. VI. AMINOPHYLLINE 1

1949 • 32 citations

Bioavailability and efficacy of a sustained‐release theophylline tablet

1974 • 32 citations

High-presure liquid chromatographic assay of theophylline in biological fluids

1974 • 32 citations

Aminophylline

1968 • 32 citations

The effects of aminophylline and other xanthines on the pulmonary circulation.

1958 • 29 citations

The Effect of Aminophylline on the Respiration and Pulmonary Circulation

1970 • 28 citations

THE EFFECT OF INTRAARTERIAL ADMINISTERED AMINOPHYLLINE ON CEREBRAL HEMODYNAMICS IN MAN

1977 • 28 citations

Gas-chromatographic quantitation of theophylline in small volumes of plasma.

1976 • 28 citations

Hemodynamic effects of aminophylline in heart failure

1966 • 27 citations

Effects of Aminophylline on the Pulmonary Circulation and Left Ventricular Performance in Patients with Valvular Heart Disease

1968 • 27 citations

Rapid gas chromatographic determination of underivatized theophylline in whole blood

1976 • 26 citations

Respiratory and Cardiovascular Effects of 3‐MethyIxanthine, a Metabolite of Theophylline

1977 • 24 citations

Blood Plasma Level of Different Theophylline Derivatives Following Parenteral, Oral and Rectal Administration

1962 • 22 citations

Drug interference with the Schack and Waxler Plasma theophylline assay

1977 • 20 citations

Comparison of the Bioavailability of Aminophylline in a Conventional Base and in a Continuous‐Release Base

1973 • 20 citations

INTERACTION BETWEEN CHOLINEA THEOPHYLLINATE AND SALMEFAMOL IN PATIENTS WITH REVERSIBLE AIRWAYS OBSTRUCTION: Study by the British Thoracic and Tuberculosis Association

1977 • 17 citations

Improved theophylline serum analysis by an appropriate internal standard for gas chromatography

1976 • 17 citations

The circulatory effects of aminophylline in man.

1969 • 16 citations

A Trial of Aerosolized Theophylline in Relieving Bronchospasm

1976 • 16 citations

Anhydrous theophylline equivalence of commercial theophylline formulations

1974 • 16 citations

Gas chromatographic analysis of theophylline in human serum

1974 • 16 citations

The supra-additive natriuretic effect addition of theophylline ethylenediamine and bumetanide in congestive heart failure

1977 • 16 citations

The hemodynamic and respiratory effects of adrenaline and theophylline derivatives in bronchial asthma.

1967 • 15 citations

Aminophylline therapy in children: Guidelines for dosage

1977 • 13 citations

A modified ultraviolet spectrophotometric method for the determination of theophylline in serum in the presence of barbiturates

1976 • 12 citations

Oral theophylline preparations--a review of their clinical efficacy in the treatment of bronchial asthma.

1974 • 11 citations

Influence of Formulation on Bioavailability Of Theophylline

1976 • 11 citations

Aminophylline bioavailability and the across-timestability of plasma theophylline levels

1977 • 11 citations

Interference by Butyl Rubber Stoppers in GLC Analysis for Theophylline

1976 • 10 citations

A Rapid and Precise Method for Determining Theophylline in Serum

1975 • 10 citations

Effect of aminophylline on coronary circulation and cardiac metabolism.

1977 • 9 citations

A rapid and sensitive method for determination of theophylline in plasma and saliva by high pressure liquid chromatography.

1976 • 8 citations

Pharmacokinetics in drug therapy II: Applications of clinical pharmacokinetics in the assessment of theophylline therapy.

1977 • 8 citations

Plasma theophylline level and ventilatory function in chronic obstructive pulmonary disease during prolonged oral treatment with choline theophyllinate

1975 • 8 citations

Comparative bioavailability of two oral dosage forms of oxtriphylline.

1977 • 7 citations

Lungenkreislauf und contractile Funktion des rechten Ventrikels bei chronischem Cor Pulmonale: Vergleichende Untersuchungen �ber den Einflu� von Aminophyllin und Heptaminol

1972 • 6 citations

Effect of Drugs on Effective Vascular Compliance in Acute Heart Failure

1975 • 6 citations

The Acute Effect of Aminophylline on Left Ventricular Function in Patients with Heart Failure

1967 • 5 citations

Oxygen and Effective Vascular Compliance in Acute Heart Failure

1975 • 2 citations

[PHARMACOLOGICAL STUDY OF FUMETERRE OFFICINAL L. II. ACTION ON SMOOTH FIBER AND ANTISEROTONIN ACTION].

1964 • 2 citations