Distribution of IL-18 and IL-18 receptor in human skin: various forms of IL-18 are produced in keratinocytes

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

Regulation of interferon-γ production by IL-12 and IL-18

1998 • 526 citations

Purification and Characterization of the Human Interleukin-18 Receptor

1997 • 471 citations

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells

1997 • 385 citations

Overview of interleukin-18: more than an interferon-γ inducing factor

1998 • 371 citations

Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells

1999 • 368 citations

Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development

1998 • 289 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

Involvement of Caspase-1 and Caspase-3 in the Production and Processing of Mature Human Interleukin 18 in Monocytic THP.1 Cells

1997 • 198 citations

Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels.

1998 • 191 citations

Human Keratinocytes Constitutively Express Interleukin-18 and Secrete Biologically Active Interleukin-18 After Treatment with Pro-Inflammatory Mediators and Dinitrochlorobenzene

1999 • 153 citations

Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.

1998 • 124 citations

Characterization of anti-human interleukin-18 (IL-18)/interferon-γ-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA

1997 • 119 citations

Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production.

1999 • 116 citations

Interleukin 18, a Cytokine Which Resembles IL-1 Structurally and IL-12 Functionally but Exerts Its Effect Independently of Both

1998 • 114 citations

Constitutive and Induced IL-18 Receptor Expression by Various Peripheral Blood Cell Subsets as Determined by Anti-hIL-18R Monoclonal Antibody

1998 • 86 citations

Human keratinocytes constitutively produce but do not process interleukin-18

2000 • 84 citations

Counterregulation of Interleukin-18 mRNA and Protein Expression During Cutaneous Wound Repair in Mice

1999 • 76 citations

Differentiation-Associated Localization of nPKCμ, a Ca++-Independent Protein Kinase C, in Normal Human Skin and Skin Diseases

1993 • 76 citations

Beta-Adrenergic Stimulation Induces Intracellular Ca++ Increase in Human Epidermal Keratinocytes

1991 • 58 citations

LPS-stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-gamma production from CD3intIL-2R beta+ T cells.

1998 • 55 citations

Human keratinocytes are major producers of IL-18: predominant expression of the unprocessed form.

2000 • 45 citations

Constitutive Expression of Both Subunits of Interleukin-12 in Human Keratinocytes

1996 • 33 citations

Preparation of a verifiable peptide-protein immunogen: Direction-controlled controlled conjugation of a synthetic fragment of the monitor peptide with myoglobin and application for sequence analysis

1988 • 22 citations