Osteoarthritis: A review of the cell biology involved and evidence for reversibility. Management rationally related to known genesis and pathophysiology

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-arthritic Human Hips. II: Correlation of Morphology with Biochemical and Metabolic Data

2013 • 1,850 citations

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips

1971 • 1,844 citations

Textbook of Rheumatology

1985 • 1,671 citations

The response of articular cartilage to mechanical injury.

1982 • 1,242 citations

The Biological Effect of Continuous Passive Motion on the Healing of Full-Thickness Defects in Articular Cartilage. An Experimental Investigation in the Rabbit

2013 • 845 citations

The biological effect of continuous passive motion on the healing of full-thickness defects in articular cartilage. An experimental investigation in the rabbit.

1980 • 832 citations

Changes in Bone Mineral Density of the Proximal Femur and Spine with Aging

1982 • 817 citations

Osteo-Arthrosis: Prevalence in the Population and Relationship between Symptoms andX-ray Changes

1966 • 694 citations

ROLE OF MECHANICAL FACTORS IN PATHOGENESIS OF PRIMARY OSTEOARTHRITIS

1972 • 589 citations

A Clinical and Experimental Study

1958 • 513 citations

Osteo-arthrosis and Disk Degeneration in an Urban Population

1958 • 472 citations

Generalized Osteoarthritis and Heberden's Nodes

1952 • 452 citations

OSTEOARTHRITIS OF THE HIP: A STUDY OF THE NATURE AND EVOLUTION OF THE DISEASE

1953 • 423 citations

The effect of prolonged physical training on the properties of long bone: a study of Wolff's Law.

1981 • 420 citations

Functional adaptation of bone to increased stress. An experimental study.

1979 • 411 citations

The Reaction of Articular Cartilage to Injury and Osteoarthritis

1974 • 380 citations

Population Studies of the Rheumatic Diseases

1969 • 372 citations

The Reaction of Articular Cartilage to Injury and Osteoarthritis

1974 • 359 citations

The effect of prolonged physical training on the properties of long bone

1981 • 333 citations

The Effects of Continuous Compression on Living Articular Cartilage

1960 • 332 citations

Behavior of Articular Chondrocytes in Cell Culture

1971 • 319 citations

Bone density, osteoarthrosis of the hip, and fracture of the upper end of the femur.

1972 • 304 citations

The Intra-Articular Effects of Immobilization on the Human Knee

1972 • 304 citations

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

1979 • 300 citations

Genetic Factors in Generalized Osteo-Arthrosis

1963 • 299 citations

Muscular control of landing from unexpected falls in man

1971 • 296 citations

Biomechanics of the Normal and Diseased Hip

1976 • 290 citations

Population Studies of the Rheumatic Diseases.

1969 • 277 citations

Bone and joint changes in lower limb amputees.

1978 • 233 citations

Biochemical Findings in Normal and Osteoarthritic Articular Cartilage. II. Chondroitin Sulfate Concentration and Chain Length, Water, and Ash Content*

1966 • 226 citations

The seats and causes of diseases investigated by anatomy

1980 • 226 citations

Antibodies to distinct types of collagens and procollagens and their application in immunohistology

1977 • 219 citations

Movement and composition of interstitial fluid of cartilage

1965 • 217 citations

Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. III. Distribution and metabolism of amino sugar-containing macromolecules.

1981 • 205 citations

The Biology of Degenerative Joint Disease.

1971 • 201 citations

Rheumatism in Miners. Part II: X-ray Study

1952 • 197 citations

The Biology of Degenerative Joint Disease

1970 • 193 citations

Über die Arthritis deformans

1926 • 181 citations

Incidence and Prognosis of Coxarthrosis

1964 • 176 citations

The lubricating activity of synovial fluid glycoproteins

1981 • 174 citations

Osteoarthrosis in Patients and Populations

1961 • 164 citations

Running Inhibits the Reversal of Atrophic Changes in Canine Knee Cartilage After Removal of a Leg Cast

1981 • 159 citations

Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog. A study using microradiographic, microangiographic, and fluorescent bone-labelling techniques.

1975 • 158 citations

The distribution of different molecular species of collagen in fibrous, elastic and hyaline cartilages of the pig

1975 • 156 citations

Hypertrophic repair of articular cartilage in experimental osteoarthrosis.

1983 • 150 citations

The Mechanical Properties of Articular Cartilage

1980 • 149 citations

A SYSTEM OF MEDICINE

1911 • 143 citations

Pathology and the Posture of Neanderthal Man

1957 • 137 citations

Heberden Oration, 1976. Molecular approach to the understanding of osteoarthrosis.

1977 • 127 citations

The Turnover of Adult Rabbit Articular Cartilage

1969 • 127 citations

A Pituitary Growth-Promoting Factor for Articular Chondrocytes in Monolayer Culture

1972 • 127 citations

Inflammatory osteoarthritis—I. The clinical syndrome

1972 • 126 citations

Interphalangeal Osteoarthritis

1961 • 126 citations

Variation of chemical composition with age in human femoral head cartilage.

1978 • 124 citations

Kinetics of osteoarthritis.

1959 • 123 citations

A Consolidated Concept of Joint Lubrication

1972 • 120 citations

Help or Hindrance?

1967 • 114 citations

Acromegalic arthropathy.

1971 • 113 citations

INTRA-ARTICULAR TEMPERATURE AS A MEASURE OF JOINT REACTION

1949 • 112 citations

Autonomy of tendon development in the embryonic chick wing

1979 • 111 citations

Rheumatic Syndromes of Myxedema

1970 • 106 citations

Immobilization and cartilage transformation into bone in the embryonic chick

1972 • 104 citations

The Physiological Oscillation of the Length of the Body

1935 • 103 citations

Attitudes towards health and physical activity in the elderly. Effects of a physical training program

1976 • 100 citations

Osteoarthritis Beginning With Inflammation

1975 • 90 citations

Immunochemical analysis of cartilage proteoglycans. Antigenic determinants of substructures

1979 • 89 citations

Articular patterns in the early course of rheumatoid arthritis

1983 • 87 citations

Joint effusions, chondrocalcinosis and other rheumatic manifestations in hypothyroidism

1975 • 87 citations

Metabolic Responses to Acute and Chronic<scp>l</scp>-Dopa Administration in Patients with Parkinsonism

1972 • 79 citations

Association of osteoarthritis and diabetes mellitus.

1961 • 76 citations

Hemiplegia and rheumatoid hemiarthritis

1968 • 75 citations

The Bursae of the Body

1965 • 74 citations

THE CLINICAL SYNDROME

1968 • 74 citations

OBLIQUE DISPLACEMENT OSTEOTOMY FOR OSTEOARTHRITIS OF THE HIP JOINT

1950 • 72 citations

Nutritional probe of the aging process.

1980 • 71 citations

Rheumatic syndromes in endocrine disease

1979 • 71 citations

Hip Joint Restoration in Juvenile Rheumatoid Arthritis

1977 • 70 citations

Spontaneous recovery of the joint space in degenerative hip disease.

1972 • 70 citations

Physical performance as a function of age

1968 • 68 citations

Progress in Clinical Rheumatology.

1965 • 67 citations

Estradiol receptors in articular chondrocytes

1982 • 64 citations

Bones, Bodies, and Disease: Evidence of Disease and Abnormality in Early Man

1964 • 64 citations

Aspirin aggravates the degeneration of canine joint cartilage caused by immobilization

1982 • 64 citations

INTERTROCHANTERIC OSTEOTOMY FOR OSTEOARTHRITIS OF THE HIP

1958 • 62 citations

Changes in the Knee Joint at Various Ages.

1943 • 62 citations

The relation of symptoms to osteoarthritis

1957 • 62 citations

Effect of purified growth factors on rabbit articular chondrocytes in monolayer culture. II. sulfated proteoglycan synthesis

1982 • 62 citations

Experimentally Induced Osteoarthritis in Guinea Pigs

1981 • 62 citations

THE INFLUENCE OF PHYSICAL THERAPY PROCEDURES ON THE INTRA-ARTICULAR TEMPERATURE OF NORMAL AND ARTHRITIC SUBJECTS

1949 • 62 citations

Low incidence of osteoarthrosis in hip and knee after anterior poliomyelitis: a late review.

1966 • 59 citations

Inflammatory osteoarthritis—II. the superimposition of rheumatoid arthritis

1972 • 58 citations

Exercise for Prevention of Osteoporosis: A Review

1982 • 55 citations

Lubrication of Joints

1964 • 55 citations

The collagenous nature of amianthoid degeneration of human costal cartilage.

1973 • 54 citations

A Study of Electrochemical Enhancement of Articular Cartilage Repair

1974 • 53 citations

[Rheumatism in miners].

1951 • 49 citations

The reversibility of osteoarthritis: A review

1983 • 49 citations

Articular cartilage atrophy in lower limb amputees

1982 • 48 citations

The antigenicity of chondrocytes.

1977 • 44 citations

Enzymatic degradation of chondromucoprotein by cell‐free extracts of human cartilage

1964 • 43 citations

Salicylate inhibition of cartilage degeneration

1965 • 43 citations

THE RESULTS OF OSTEOTOMY FOR EARLY PRIMARY OSTEOARTHRITIS OF THE HIP

1964 • 42 citations

The Protective Effect of Aspirin Against Degeneration of Human Articular Cartilage

1972 • 42 citations

Preliminary experience with cell culture of human articular chondrocytes

1974 • 42 citations

Effects of a high fat diet on the joints of aging mice.

1950 • 40 citations

Changes induced by sustained pressure in the knee joint articular cartilage of adult rabbits

1964 • 39 citations

Wear properties of articular cartilage in vitro

1971 • 38 citations

The Influence of Immobilization and Motion on the Formation of Fibrocartilage in the Repair Granuloma after Joint Resection in the Rabbit

1966 • 38 citations

Growth Promotion by Homocysteic Acid

1976 • 37 citations

Osteoarthritis, crystal deposition, and inflammation

1981 • 36 citations

PRIMARY LESION IN OSTEOARTHROSIS

1977 • 35 citations

Bones, bodies and disease : evidence of disease and abnormality in early man

1964 • 34 citations

Chronic Arthritis in Wild Mammals. Being a Description of Lesions Found in the Collections of Several Museums and from a Pathological Service

1939 • 34 citations

Proline and Hydroxyproline Excretion and Vitamin C Status in Elderly Human Subjects

1977 • 34 citations

Stimulation of dna synthesis by ascorbate in cultures of articular chondrocytes

1982 • 34 citations

[3H]proline incorporation and hydroxyproline concentration in articular cartilage during the development of osteoarthritis caused by immobilization. A study in vivo with rabbits

1981 • 33 citations

Glycosaminoglycan Metabolism in Experimental Osteoarthritis Caused by Immobilization:The Effects of Different Periods of Immobilization and Follow-up

1981 • 32 citations

The measurement of rates of mineral loss with aging.

1976 • 31 citations

A 5-year follow-up of fifty cases of idiopathic osteoarthritis of the hip.

1969 • 29 citations

Osteoarthritis beginning with inflammation. Definitions and correlations

1975 • 28 citations

The antiquity of disease

2010 • 23 citations

The Effect of Growth Hormone on Established Cartilage Lesions

1975 • 23 citations

Degenerative arthritis: A comparison of the pathological changes in man and equines.

1938 • 22 citations

McMURRAY OSTEOTOMY

1960 • 22 citations

RHEUMATIC COMPLAINTS

1971 • 20 citations

The Human Joint in Health and Disease

1978 • 20 citations

Rationale and Indications for the ???Hanging Hip??? Procedure A Clinical and Experimental Study

1975 • 19 citations

Degenerative joint disease in Praomys (Mastomys) natalensis.

1967 • 19 citations

New types of calcium phosphate crystals in arthritic cartilage

1981 • 19 citations

Restoration of the femoral head after collapse in osteoarthrosis.

1971 • 19 citations

DISPLACEMENT OSTEOTOMY OF THE UPPER END OF THE FEMUR

1955 • 19 citations

Coalescence of caudal vertebrae in the giant dinosaur Diplodocus

1961 • 19 citations

Nutritional Requirements in the Elderly

1982 • 17 citations

Musculoskeletal complaints in an industry annual complaint rate and diagnosis, absenteeism and economic loss

1961 • 17 citations

A New Look at Developmental Subluxation and Dislocation: Hip Dysplasia in the Dog

1963 • 17 citations

Sulphur Metabolism in Cartilage

1958 • 14 citations

Arthritis in the Mediterranean Theater of Operations

1947 • 13 citations

“Milwaukee shoulder” syndrome: Microspherules containing hydroxyapatite, active collagenase and neutral protease in patients with rotator cuff defects and glenohumeral osteoarthritis

1981 • 13 citations

Pathology of the Connective Tissue Disease

1966 • 13 citations

Modulation of chondrocyte synthesis by lymphokine-rich conditioned media

1982 • 12 citations

Edward A. Dunlop lecture. Cell biology and the repair of articular cartilage.

1974 • 11 citations

Remodeling of the Hip Joint in Juvenile Rheumatoid Arthritis

1981 • 11 citations

Partial reversal by beta‐d‐xyloside of salicylate‐induced inhibition of glycosaminoglycan synthesis in articular cartilage

1982 • 11 citations

Sulphate Metabolism in Cartilage

1962 • 10 citations

Structure and Function of Lubricin, the Glycoprotein Responsible for the Boundary Lubrication of Articular Cartilage

2015 • 9 citations

The Clinical Apprentice.

1980 • 9 citations

The Response of Transplanted Articular Cartilage to Growth Hormone

1974 • 9 citations

Human Skeletal Growth Factor Isolated

1982 • 8 citations

Degenerative joint disease in birds.

1963 • 8 citations

Enzymatic studies on the skeletal myosin A and actomyosin of aging rats

1975 • 7 citations

Effect of salicylate on the surgical inducement of joint degeneration in rabbit knees

1976 • 6 citations

The Effects of Training on the Aging Process

1978 • 4 citations

Osteotorny as an Alternative to Total Hip Replacement in Young Adults

1977 • 4 citations

The role of catabolin in arthritic damage

1981 • 3 citations

OSTEOARTHRITIS OF THE HIP-JOINT

1960 • 3 citations

The role of estrogen and oophorectomy in immune synovitis

1981 • 3 citations

Deleted Work

1955 • 0 citations