Inter- and intra-subject variation in the first-pass elimination of highly cleared drugs during chronic dosing

Applied Nonparametric Statistics

1991 • 5,126 citations

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

Verapamil

1978 • 829 citations

Drug Use in the Elderly

1978 • 290 citations

Influence of Route of Administration on Drug Availability

1972 • 261 citations

Physiological disposition of verapamil in man

1976 • 244 citations

Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. I. Hemodynamic effects.

1979 • 226 citations

Enhancement of the bioavailability of propranolol and metoprolol by food

1977 • 210 citations

The metabolism of DL-[14C]verapamil in man.

1979 • 167 citations

Influence of the Route of Administration on the Area Under the Plasma Concentration-Time Curve

1969 • 140 citations

Direct measurement of propranolol bioavailability during accumulation to steady‐state.

1978 • 121 citations

Reduced verapamil clearance during long-term oral administration

1981 • 119 citations

Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosis.

1981 • 118 citations

Pharmacokinetics of Drug Disposition: Hemodynamic Considerations

1975 • 116 citations

Verapamil kinetics in normal subjects and patients with coronary artery spasm

1981 • 113 citations

Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil

1981 • 105 citations

Pharmacokinetics of nortriptyline in man after single and multiple oral doses: The predictability of steady-state plasma concentrations from single-dose plasma-level data

1972 • 99 citations

High-performance liquid chromatographic analysis of verapamil. II. Simultaneous quantitation of verapamil and its active metabolite, norverapamil.

1980 • 98 citations

Verapamil in cardiology.

1974 • 97 citations

Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment

1980 • 97 citations

Calciumantagonistische Therapie bei hypertroph-obstruktiver Kardiomyopathie

1976 • 94 citations

High-performance liquid chromatographic analysis of verapamil

1980 • 91 citations

Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy.

1980 • 91 citations

Physiological and pharmacological variability in estimated hepatic blood flow in man.

1981 • 86 citations

Prolongation of verapamil elimination kinetics during chronic oral administration

1982 • 77 citations

Applied Nonparametric Statistics

1979 • 74 citations

Hydralazine kinetics after single and repeated oral doses

1980 • 71 citations

Superiority of stable isotope techniques in the assessment of the bioavailability of drugs undergoing extensive first pass elimination

1981 • 69 citations

Intraindividual variation in drug disposition

1979 • 66 citations

Symbols in pharmacokinetics

1980 • 66 citations

Lorcainide; I. Saturable presystemic elimination

1979 • 61 citations

Simultaneous determination of verapamil and its seven metabolites by high-performance liquid chromatography

1981 • 52 citations

Variability of beta-blocker pharmacokinetics in young volunteers

1982 • 46 citations

Determination of verapamil in human plasma by mass fragmentography using stable isotope-labelled verapamil as internal standard.

1977 • 45 citations

Drug Pharmacokinetics in Cardiac and Hepatic Disease

1980 • 45 citations

Individual Differences in the Disposition of Drugs Metabolised in the Body

1978 • 42 citations

Influence of meso‐caval shunt surgery on verapamil kinetics, bioavailability and response.

1980 • 31 citations

Direct determination of hepatic extraction of verapamil in cardiac patients

1981 • 30 citations

Prediction of bioavailability for drugs with a high first-pass effect using oral clearance data

1982 • 17 citations

SYMBOLS IN PHARMACOKINETICS1.

1982 • 9 citations