Chymotrypsin-catalyzed phenyl ester hydrolysis. Evidence for electrophilic assistance on carbonyl oxygen

The Nature of the Chemical Bond

1939 • 13,296 citations

Statistical estimations in enzyme kinetics

1961 • 3,586 citations

Catalysis in chemistry and enzymology

1969 • 3,236 citations

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

Structure of crystalline α-chymotrypsin

1968 • 435 citations

Structure of crystalline α-chymotrypsin

1969 • 374 citations

Prediction of the strengths of organic acids

1966 • 238 citations

The Current Status of the α-Chymotrypsin Mechanism

1964 • 195 citations

Kinetic Evidence for the Formation of Acyl-Enzyme Intermediates in the α-Chymotrypsin-Catalyzed Hydrolyses of Specific Substrates

1964 • 174 citations

The Correlation of the pH (pD) Dependence and the Stepwise Mechanism of α-Chymotrypsin-Catalyzed Reactions

1964 • 170 citations

The Kinetic Consequences of the Acyl-Enzyme Mechanism for the Reactions of Specific Substrates with Chymotrypsin

1964 • 146 citations

Facilitated Proton Transfer in Enzyme Catalysis

1968 • 119 citations

Atomic CO-ordinates for tosyl-α-chymotrypsin

1969 • 104 citations

PAPAIN-CATALYSED HYDROLYSIS OF SOME HIPPURIC ESTERS. A NEW MECHANISM FOR PAPAIN-CATALYSED HYDROLYSIS

1965 • 78 citations

The Effect of Structure on the Rates of Some α-Chymotrypsin-catalyzed Reactions

1962 • 69 citations

An Active Center Histidine Peptide of α-Chymotrypsin

1964 • 58 citations

PROTONATION OF THE AMIDE GROUP: I. THE BASICITIES OF SUBSTITUTED BENZAMIDES

1960 • 57 citations

Carbonyl Oxygen Exchange in General Base Catalyzed Ester Hydrolysis

1967 • 57 citations

Participation of an Acidic Group in the Chymotrypsin Catalysis***

1969 • 43 citations

An Electrophilic Mechanism in the Chymotrypsin-Catalyzed Hydrolysis of Anilide Substrates¹

1965 • 40 citations

The Formation of an Acyl-enzyme Intermediate in the α-Chymotrypsin-catalyzed Hydrolyses of Non-labile trans-Cinnamic Acid Esters^1-3

1962 • 37 citations

Introduction to the Chemistry of Enzymes

1954 • 28 citations

Chymotrypsin-Catalyzed Hydrolysis of m-, p-, and o-Nitroanilides of N-Benzoyl-L-tyrosine^*

1966 • 27 citations

Transition State Differences between Amides and Esters in Chymotrypsin-Catalyzed Hydrolysis

1963 • 25 citations

The Protonic Equilibrium Accompanying the Acylation of Chymotrypsin and Subtilisin^*

1966 • 24 citations

Pretransition-state protonation and the rate of chymotrypsin catalysis.

1967 • 23 citations

N‐Methansulfonyl‐derivate von Aminosäuren und Oligopeptiden

1940 • 22 citations