Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3

2000 • 848 citations

Structure of a c-Cbl–UbcH7 Complex

2000 • 824 citations

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity

2002 • 787 citations

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

2001 • 782 citations

Nuclear and unclear functions of SUMO

2003 • 651 citations

An E3-like Factor that Promotes SUMO Conjugation to the Yeast Septins

2001 • 642 citations

Identification of a SUMO-binding motif that recognizes SUMO-modified proteins

2004 • 564 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

Structure of an E6AP-UbcH7 Complex: Insights into Ubiquitination by the E2-E3 Enzyme Cascade

1999 • 539 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

A giant nucleopore protein that binds Ran/TC4

1995 • 492 citations

PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

2002 • 420 citations

SUMO: ligases, isopeptidases and nuclear pores

2003 • 387 citations

Ubch9 conjugates SUMO but not ubiquitin

1997 • 349 citations

Structural insights into the U-box, a domain associated with multi-ubiquitination

2003 • 276 citations

PIAS1 and PIASxα Function as SUMO-E3 Ligases toward Androgen Receptor and Repress Androgen Receptor-dependent Transcription

2002 • 208 citations

Impact of Transverse Relaxation Optimized Spectroscopy (TROSY) on NMR as a technique in structural biology

2000 • 159 citations

Stabilization of the E3 Ubiquitin Ligase Nrdp1 by the Deubiquitinating Enzyme USP8

2004 • 156 citations

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type

2004 • 154 citations

A RING Finger Ubiquitin Ligase Is Protected from Autocatalyzed Ubiquitination and Degradation by Binding to Ubiquitin-specific Protease USP7

2004 • 143 citations

Crystal Structure of Murine/Human Ubc9 Provides Insight into the Variability of the Ubiquitin-conjugating System

1997 • 132 citations

A novel factor required for the SUMO1/Smt3 conjugation of yeast septins

2001 • 128 citations

Domain Organization of IκBα and Sites of Interaction with NF-κB p65

1995 • 124 citations

Identification of a Multifunctional Binding Site on Ubc9p Required for Smt3p Conjugation

2002 • 122 citations

Role of an N-Terminal Site of Ubc9 in SUMO-1, -2, and -3 Binding and Conjugation

2003 • 96 citations

The Binding Interface between an E2 (UBC9) and a Ubiquitin Homologue (UBL1)

1999 • 95 citations

Protein Interactions within the N-end Rule Ubiquitin Ligation Pathway

2003 • 80 citations

Perturbation of SUMOlation Enzyme Ubc9 by Distinct Domain within Nucleoporin RanBP2/Nup358

2002 • 60 citations

Structure of Ubiquitin-Conjugating Enzyme 9 Displays Significant Differences with Other Ubiquitin-Conjugating Enzymes Which May Reflect its Specificity for Sumo Rather Than Ubiquitin

1998 • 58 citations