Synaptic integration in dendritic trees

Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type

1998 • 4,476 citations

The Nervous System

1991 • 2,567 citations

Neuronal Calcium Signaling

1998 • 2,126 citations

From Ionic Currents to Molecular Mechanisms

2000 • 2,039 citations

THE PHYSIOLOGY OF SYNAPSES

1964 • 1,932 citations

Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.

1980 • 1,759 citations

Gamma Oscillation by Synaptic Inhibition in a Hippocampal Interneuronal Network Model

1996 • 1,577 citations

Two networks of electrically coupled inhibitory neurons in neocortex

1999 • 1,450 citations

K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons

1997 • 1,415 citations

Electric current flow in excitable cells

1976 • 1,353 citations

Active propagation of somatic action potentials into neocortical pyramidal cell dendrites

1994 • 1,303 citations

The Physiology of Synapses

1964 • 1,239 citations

A new cellular mechanism for coupling inputs arriving at different cortical layers

1999 • 1,171 citations

Molecular Diversity of K⁺ Channels

1999 • 1,117 citations

Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition

2001 • 1,095 citations

Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.

1980 • 1,043 citations

Branching dendritic trees and motoneuron membrane resistivity

1959 • 1,004 citations

Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input.

1967 • 1,003 citations

Dendritic Hyperpolarization-Activated Currents Modify the Integrative Properties of Hippocampal CA1 Pyramidal Neurons

1998 • 992 citations

Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex.

1997 • 984 citations

A network of fast-spiking cells in the neocortex connected by electrical synapses

1999 • 969 citations

Activity-Dependent Action Potential Invasion and Calcium Influx into Hippocampal CA1 Dendrites

1995 • 846 citations

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

1991 • 832 citations

Computational subunits in thin dendrites of pyramidal cells

2004 • 805 citations

Action potential initiation and backpropagation in neurons of the mammalian CNS

1997 • 774 citations

Pyramidal Neuron as Two-Layer Neural Network

2003 • 756 citations

Excitatory GABA Responses in Embryonic and Neonatal Cortical Slices Demonstrated by Gramicidin Perforated-Patch Recordings and Calcium Imaging

1996 • 736 citations

Dendritic release of dopamine in the substantia nigra

1981 • 732 citations

Two components of long-term potentiation induced by different patterns of afferent activation

1990 • 704 citations

NMDA spikes in basal dendrites of cortical pyramidal neurons

2000 • 701 citations

Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons

2000 • 655 citations

Impact of Network Activity on the Integrative Properties of Neocortical Pyramidal Neurons In Vivo

1999 • 638 citations

Propagation of Action Potentials in Dendrites Depends on Dendritic Morphology

2001 • 621 citations

Calcium- and activity-dependent synaptic plasticity

1999 • 618 citations

Theory of Physiological Properties of Dendrites

1962 • 586 citations

Theoretical Significance of Dendritic Trees for Neuronal Input-Output Relations (1964)

1994 • 561 citations

Intradendritic recordings from hippocampal neurons.

1979 • 560 citations

Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites

1998 • 541 citations

Synaptic background activity influences spatiotemporal integration in single pyramidal cells.

1991 • 535 citations

Calcium Entry Leads to Inactivation of Calcium Channel in Paramecium

1978 • 532 citations

Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons

1997 • 526 citations

Olfactory Reciprocal Synapses: Dendritic Signaling in the CNS

1998 • 507 citations

Impact of Spontaneous Synaptic Activity on the Resting Properties of Cat Neocortical Pyramidal Neurons In Vivo

1998 • 469 citations

Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites

2002 • 453 citations

Synaptic Activation of Voltage-Gated Channels in the Dendrites of Hippocampal Pyramidal Neurons

1995 • 449 citations

Direct Measurement of Specific Membrane Capacitance in Neurons

2000 • 437 citations

Electric Current Flow in Excitable Cells.

1975 • 435 citations

Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current

1989 • 434 citations

Participation of calcium spikes during intrinsic burst firing in hippocampal neurons

1978 • 425 citations

Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons

2001 • 424 citations

Dendritic Sodium Spikes Are Variable Triggers of Axonal Action Potentials in Hippocampal CA1 Pyramidal Neurons

1998 • 408 citations

Excitatory Actions of GABA in the Cortex

2003 • 395 citations

Dendritic calcium transients evoked by single back‐propagating action potentials in rat neocortical pyramidal neurons.

1995 • 394 citations

Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance

1992 • 392 citations

Dependence of EPSP Efficacy on Synapse Location in Neocortical Pyramidal Neurons

2002 • 382 citations

Distal Initiation and Active Propagation of Action Potentials in Interneuron Dendrites

2000 • 382 citations

Downregulation of Transient K⁺Channels in Dendrites of Hippocampal CA1 Pyramidal Neurons by Activation of PKA and PKC

1998 • 380 citations

Vesicular Dopamine Release Elicits an Inhibitory Postsynaptic Current in Midbrain Dopamine Neurons

2004 • 360 citations

Branch Input Resistance and Steady Attenuation for Input to One Branch of a Dendritic Neuron Model

1973 • 357 citations

Initiation and spread of sodium action potentials in cerebellar purkinje cells

1994 • 356 citations

Site Independence of EPSP Time Course Is Mediated by DendriticI _h in Neocortical Pyramidal Neurons

2000 • 350 citations

Dendritic coincidence detection of EPSPs and action potentials

2001 • 334 citations

Dendritic Calcium Spike Initiation and Repolarization Are Controlled by Distinct Potassium Channel Subtypes in CA1 Pyramidal Neurons

1999 • 333 citations

Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network

2001 • 327 citations

Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons

1999 • 316 citations

Synaptic excitation of inhibitory cells by single CA3 hippocampal pyramidal cells of the guinea‐pig in vitro.

1990 • 315 citations

Functional Conversion Between A-Type and Delayed Rectifier K ⁺ Channels by Membrane Lipids

2004 • 315 citations

Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons

1995 • 312 citations

Apical dendrites of the neocortex: correlation between sodium- and calcium-dependent spiking and pyramidal cell morphology

1993 • 310 citations

Axonal Action-Potential Initiation and Na⁺Channel Densities in the Soma and Axon Initial Segment of Subicular Pyramidal Neurons

1996 • 309 citations

P-type calcium channels in the somata and dendrites of adult cerebellar purkinje cells

1992 • 308 citations

Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons

1999 • 303 citations

Calcium transients in dendrites of neocortical neurons evoked by single subthreshold excitatory postsynaptic potentials via low-voltage-activated calcium channels.

1994 • 299 citations

High I _h Channel Density in the Distal Apical Dendrite of Layer V Pyramidal Cells Increases Bidirectional Attenuation of EPSPs

2001 • 297 citations

Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices

1994 • 297 citations

Ca2+ accumulations in dendrites of neocortical pyramidal neurons: An apical band and evidence for two functional compartments

1994 • 296 citations

Dendritic Voltage-Gated Ion Channels Regulate the Action Potential Firing Mode of Hippocampal CA1 Pyramidal Neurons

1999 • 295 citations

Untangling Dendrites with Quantitative Models

2000 • 295 citations

Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons

1995 • 292 citations

Dendritic attenuation of synaptic potentials and currents: the role of passive membrane properties

1994 • 287 citations

Compartmental models of rat cerebellar Purkinje cells based on simultaneous somatic and dendritic patch‐clamp recordings

2001 • 279 citations

Transient Response in a Dendritic Neuron Model for Current Injected at One Branch

1974 • 278 citations

Slow Recovery from Inactivation of Na⁺Channels Underlies the Activity-Dependent Attenuation of Dendritic Action Potentials in Hippocampal CA1 Pyramidal Neurons

1997 • 269 citations

Analysis of calcium channels in single spines using optical fluctuation analysis

2000 • 268 citations

Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro

1995 • 267 citations

Submillisecond Precision of the Input-Output Transformation Function Mediated by Fast Sodium Dendritic Spikes in Basal Dendrites of CA1 Pyramidal Neurons

2003 • 267 citations

Dendritic potassium channels in hippocampal pyramidal neurons

2000 • 265 citations

Forward and Backward Propagation of Dendritic Impulses and Their Synaptic Control in Mitral Cells

1997 • 265 citations

Selective Coupling of T-Type Calcium Channels to SK Potassium Channels Prevents Intrinsic Bursting in Dopaminergic Midbrain Neurons

2002 • 263 citations

Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells.

1976 • 261 citations

Plasticity of calcium channels in dendritic spines

2003 • 258 citations

Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo

1999 • 257 citations

Active dendrites, potassium channels and synaptic plasticity

2003 • 249 citations

Regenerative Activity in Apical Dendrites of Pyramidal Cells in Neocortex

1993 • 249 citations

Voltage‐gated K⁺ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients

2000 • 241 citations

Prolonged Sodium Channel Inactivation Contributes to Dendritic Action Potential Attenuation in Hippocampal Pyramidal Neurons

1997 • 232 citations

A Brief History of Time (Constants)

1996 • 229 citations

Supralinear Ca²⁺Influx into Dendritic Tufts of Layer 2/3 Neocortical Pyramidal NeuronsIn VitroandIn Vivo

2003 • 227 citations

The role of bicarbonate in GABAA receptor‐mediated IPSPs of rat neocortical neurones.

1993 • 218 citations

Electrophysiology of isolated hippocampal pyramidal dendrites

1982 • 209 citations

Calcium-dependent inactivation of neuronal calcium channels

2002 • 207 citations

Role of dendritic synapse location in the control of action potential output

2003 • 206 citations

Modulation of the hyperpolarization‐activated current (Ih) by cyclic nucleotides in guinea‐pig primary afferent neurons.

1996 • 206 citations

Compartmentalized and Binary Behavior of Terminal Dendrites in Hippocampal Pyramidal Neurons

2001 • 203 citations

Multiple Channel Types Contribute to the Low-Voltage-Activated Calcium Current in Hippocampal CA3 Pyramidal Neurons

1996 • 195 citations

Action Potential Backpropagation and Somato-dendritic Distribution of Ion Channels in Thalamocortical Neurons

2000 • 193 citations

Dendritic Na+ channels amplify EPSPs in hippocampal CA1 pyramidal cells

1996 • 192 citations

Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb

2000 • 186 citations

Distribution and activation of voltage‐gated potassium channels in cell‐attached and outside‐out patches from large layer 5 cortical pyramidal neurons of the rat

2000 • 182 citations

Membrane potential bistability is controlled by the hyperpolarization‐activated current I_H in rat cerebellar Purkinje neurons in vitro

2002 • 177 citations

Coexistence of Excitatory and Inhibitory GABA Synapses in the Cerebellar Interneuron Network

2003 • 175 citations

Mechanisms of Lateral Inhibition in the Olfactory Bulb: Efficiency and Modulation of Spike-Evoked Calcium Influx into Granule Cells

2003 • 171 citations

Maturation of layer 5 neocortical pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca²⁺ action potentials in adult rat tuft dendrites

2000 • 170 citations

Regulation of back-propagating action potentials in hippocampal neurons

1999 • 169 citations

Cellular biology of neurons

1977 • 167 citations

Dynamic Gating of Spike Propagation in the Mitral Cell Lateral Dendrites

2002 • 163 citations

Input Summation by Cultured Pyramidal Neurons Is Linear and Position-Independent

1998 • 163 citations

Action potential propagation into the presynaptic dendrites of rat mitral cells

1997 • 158 citations

Passive Normalization of Synaptic Integration Influenced by Dendritic Architecture

1999 • 158 citations

Cell-Type-Specific GABA Responses and Chloride Homeostasis in the Cortex and Amygdala

2001 • 156 citations

Regulation of Firing Response Gain by Calcium-Dependent Mechanisms in Vestibular Nucleus Neurons

2002 • 151 citations

Dendritic Resonance in Rat Neocortical Pyramidal Cells

2002 • 147 citations

The amplitude, time course and charge of unitary excitatory post‐synaptic potentials evoked in spinal motoneurone dendrites

1973 • 146 citations

Depolarizing GABA‐activated Cl‐ channels in embryonic rat spinal and olfactory bulb cells.

1995 • 146 citations

Dendritic Spikes and Their Inhibition in Alligator Purkinje Cells

1968 • 145 citations

Dendritic Control of Spontaneous Bursting in Cerebellar Purkinje Cells

2004 • 143 citations

Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells.

1996 • 141 citations

The inhibitory suppression of reflex discharges from motoneurones

1955 • 140 citations

Visibility of synaptically induced conductance changes: theory and simulations of anatomically characterized cortical pyramidal cells

1990 • 139 citations

Signal delay and input synchronization in passive dendritic structures

1993 • 139 citations

Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production

1999 • 134 citations

Action Potentials in Basal and Oblique Dendrites of Rat Neocortical Pyramidal Neurons

2003 • 133 citations

N-type Ca2+ channels are located on somata, dendrites, and a subpopulation of dendritic spines on live hippocampal pyramidal neurons

1994 • 125 citations

Hyperpolarization-Activated Current I_h Disconnects Somatic and Dendritic Spike Initiation Zones in Layer V Pyramidal Neurons

2003 • 123 citations

The time course of synaptic potentials evoked in cat spinal motoneurones at identified group Ia synapses.

1983 • 117 citations

Intrinsic determinants of firing pattern in Purkinje cells of the turtle cerebellum in vitro.

1988 • 114 citations

Self-excitation of olfactory bulb neurones

1982 • 109 citations

Backpropagation of Physiological Spike Trains in Neocortical Pyramidal Neurons: Implications for Temporal Coding in Dendrites

2000 • 109 citations

A Fast-Conducting, Stochastic Integrative Mode for Neocortical NeuronsInVivo

2003 • 106 citations

Natural History of the Nerve Impulse

1956 • 106 citations

Differential Shunting of EPSPs by Action Potentials

2001 • 105 citations

Inhibition of Backpropagating Action Potentials in Mitral Cell Secondary Dendrites

2002 • 104 citations

Global dendritic calcium spikes in mouse layer 5 low threshold spiking interneurones: implications for control of pyramidal cell bursting

2004 • 103 citations

Amplification of EPSPs by Low Ni²⁺- and Amiloride-Sensitive Ca²⁺ Channels in Apical Dendrites of Rat CA1 Pyramidal Neurons

1997 • 103 citations

Cable properties of cultured hippocampal neurons determined from sucrose-evoked miniature EPSCs

1996 • 101 citations

Low-Threshold Ca²⁺Currents in Dendritic Recordings from Purkinje Cells in Rat Cerebellar Slice Cultures

1997 • 100 citations

Dendritic Glutamate Autoreceptors Modulate Signal Processing in Rat Mitral Cells

2001 • 99 citations

Action Potential Initiation and Propagation in Layer 5 Pyramidal Neurons of the Rat Prefrontal Cortex: Absence of Dopamine Modulation

2003 • 96 citations

Ca2+ imaging of mouse neocortical interneurone dendrites: Ia-type K+ channels control action potential backpropagation

2003 • 88 citations

Activity of dendrites of single Purkinje cells and its relationship to so-called inactivation response in rabbit cerebellum.

1968 • 87 citations

Passive electrotonic properties of rat hippocampal CA3 interneurones

1999 • 85 citations

Action Potential Propagation in Dendrites of Rat Mitral CellsIn Vivo

2003 • 76 citations

GABA-Dependent Firing of Glutamate-Evoked Action Potentials at AMPA/Kainate Receptors in Developing Hypothalamic Neurons

1998 • 74 citations

Dendritic I_hSelectively Blocks Temporal Summation of Unsynchronized Distal Inputs in CA1 Pyramidal Neurons

2003 • 72 citations

Arachidonic Acid Reciprocally Alters the Availability of Transient and Sustained Dendritic K⁺Channels in Hippocampal CA1 Pyramidal Neurons

1999 • 67 citations

Regulation of Backpropagating Action Potentials in Mitral Cell Lateral Dendrites by A-Type Potassium Currents

2003 • 64 citations

The attenuation of passively propagating dendritic potentials in a motoneurone cable model

1973 • 63 citations

Cell Type- and Subcellular Position-Dependent Summation of Unitary Postsynaptic Potentials in Neocortical Neurons

2002 • 63 citations

Summation of excitatory postsynaptic potentials in hippocampal pyramidal cells

1983 • 54 citations

Boosting of neuronal firing evoked with asynchronous and synchronous inputs to the dendrite

2002 • 54 citations

Synaptic integration mechanisms. Theoretical and experimental investigation of temporal postsynaptic interactions between excitatory and inhibitory inputs

1983 • 52 citations

Distance-Dependent Modifiable Threshold for Action Potential Back-Propagation in Hippocampal Dendrites

2003 • 51 citations

Subcellular distribution of high‐voltage‐activated calcium channel subtypes in rat globus pallidus neurons

2001 • 48 citations

Potentiometric study of resting potential, contributing K⁺ channels and the onset of Na⁺ channel excitability in embryonic rat cortical cells

1998 • 46 citations

Localization and developmental changes of the expression of two inward rectifying K+-channel proteins in the rat brain

1997 • 43 citations

Spatial integration of local transmitter responses in motoneurones of the turtle spinal cord in vitro.

1994 • 40 citations

Integration of Excitatory Postsynaptic Potentials in Dendrites of Motoneurons of Rat Spinal Cord Slice Cultures

1998 • 39 citations

Different spatial patterns of [Ca2+] increase caused by N‐ and L‐type Ca2+ channel activation in frog olfactory bulb neurones.

1995 • 38 citations

Electrotonic profile and passive propagation of synaptic potentials in three subpopulations of hippocampal CA1 interneurons

2001 • 37 citations

Distance-Dependent Ni²⁺-Sensitivity of Synaptic Plasticity in Apical Dendrites of Hippocampal CA1 Pyramidal Cells

2002 • 36 citations

Whole cell calcium currents in acutely isolated olfactory bulb output neurons of the rat

1996 • 33 citations

Influence of r-type (Cav2.3) and t-type (Cav3.1–3.3) antagonists on nigral somatodendritic dopamine release measured by microdialysis

2003 • 30 citations

Electrical consequences of spine dimensions in a model of a cortical spiny stellate cell completely reconstructed from serial thin sections

1995 • 28 citations

Fast sodium channel dependency of the somatodendritic release of dopamine in the rat's brain

1992 • 26 citations