Peroxynitrite increases iNOS through NF-κB and decreases prostacyclin synthase in endothelial cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation

1998 • 983 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Enhanced Peroxynitrite Formation Is Associated with Vascular Aging

2000 • 653 citations

Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages

1999 • 294 citations

Tyrosine Nitration as a Mechanism of Selective Inactivation of Prostacyclin Synthase by Peroxynitrite

1997 • 287 citations

Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.

1997 • 270 citations

Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.

1996 • 265 citations

Proteolytic Degradation of Tyrosine Nitrated Proteins

2000 • 260 citations

Nitrotyrosine Residues in Placenta

1996 • 253 citations

Inhibition of Endothelial Vascular Cell Adhesion Molecule-1 Expression by Nitric Oxide Involves the Induction and Nuclear Translocation of IκBα

1997 • 250 citations

Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.

1995 • 250 citations

Evidence for Peroxynitrite Formation in the Vasculature of Women With Preeclampsia

1999 • 232 citations

Generation of reactive oxygen intermediates, activation of NF-κB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?

1999 • 213 citations

Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia

1992 • 209 citations

Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B

1999 • 200 citations

Effects of nitric oxide and nitric oxide‐derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis

1999 • 170 citations

Oxidative Stress and Altered Endothelial Cell Function in Preeclampsia

1998 • 159 citations

Elevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre‐eclampsia

1997 • 157 citations

Role of peroxynitrite in altered fetal-placental vascular reactivity in diabetes or preeclampsia

2000 • 140 citations

Inducible nitric oxide synthase: a little bit of good in all of us

2000 • 127 citations

Loss of endothelium‐dependent relaxation in myometrial resistance arteries in pre‐eclampsia

1997 • 121 citations

Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells

2001 • 121 citations

cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation

2000 • 118 citations

Oxidant stress in the vasculature

1999 • 116 citations

Plasma and 24-h NO_xand cGMP during normal pregnancy and preeclampsia in women on a reduced NO_xdiet

1999 • 111 citations

Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase

2000 • 104 citations

Constitutive expression and structural diversity of inducible isoform of nitric oxide synthase in human tissues

1996 • 104 citations

Evidence for iNOS-dependent peroxynitrite production in diabetic platelets

1999 • 96 citations

Possible pathophysiological mechanisms for diabetic angiopathy in type 2 diabetes

2000 • 89 citations

Expression of Cyclo-oxygenase-2 in Human Atherosclerotic Carotid Arteries

2000 • 86 citations

Hypoxia Induces High-Mobility-Group Protein I(Y) and Transcription of the Cyclooxygenase-2 Gene in Human Vascular Endothelium

1998 • 84 citations

Competition for p300 Regulates Transcription by Estrogen Receptors and Nuclear Factor-κB in Human Coronary Smooth Muscle Cells

2000 • 82 citations

Hypoxia–Reoxygenation Triggers Coronary Vasospasm in Isolated Bovine Coronary Arteries via Tyrosine Nitration of Prostacyclin Synthase

1999 • 79 citations

Increased Activity of Nuclear Factor-κB Participates in Cardiovascular Remodeling Induced by Chronic Inhibition of Nitric Oxide Synthesis in Rats

2000 • 78 citations

Expression of inducible nitric oxide synthase in human coronary atherosclerotic plaque

1999 • 75 citations

PEROXYNITRITE INACTIVATES PROSTACYCLIN SYNTHASE BY HEME–THIOLATE-CATALYZED TYROSINE NITRATION

1999 • 74 citations

Peroxynitrite Mediates IL-8 Gene Expression and Production in Lipopolysaccharide-Stimulated Human Whole Blood

1998 • 64 citations

Aging Increases PGHS-2–Dependent Vasoconstriction in Rat Mesenteric Arteries

2000 • 60 citations

Peroxynitrite inhibits inducible (type 2) nitric oxide synthase in murine lung epithelial cells in vitro

2001 • 32 citations

Rapid Induction of NF-κB Binding during Liver Cell Isolation and Culture: Inhibition byL-NAMEIndicates a Role for Nitric Oxide Synthase

1999 • 28 citations