Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

The role of iron regulatory proteins in mammalian iron homeostasis and disease

2006 • 988 citations

Cell death in the nervous system

2006 • 616 citations

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function

2002 • 418 citations

The Relevance of Iron in the Pathogenesis of Parkinson's Disease

2004 • 331 citations

Iron Acquired from Transferrin by K562 Cells Is Delivered into a Cytoplasmic Pool of Chelatable Iron(II)

1995 • 320 citations

The Human Nramp2 Gene: Characterization of the Gene Structure, Alternative Splicing, Promoter Region and Polymorphisms

1998 • 314 citations

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat

2001 • 287 citations

The Metabolism of Neuronal Iron and Its Pathogenic Role in Neurological Disease: Review

2004 • 236 citations

Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload

2000 • 234 citations

Nramp 2 (DCT1/DMT1) Expressed at the Plasma Membrane Transports Iron and Other Divalent Cations into a Calcein-accessible Cytoplasmic Pool

2000 • 190 citations

Novel multifunctional neuroprotective iron chelator‐monoamine oxidase inhibitor drugs for neurodegenerative diseases.In vivoselective brain monoamine oxidase inhibition and prevention of MPTP‐induced striatal dopamine depletion

2005 • 184 citations

Iron metabolism in Parkinsonian syndromes

2006 • 179 citations

Apoptotic interactions of cytochrome c: Redox flirting with anionic phospholipids within and outside of mitochondria

2006 • 175 citations

A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin

1992 • 168 citations

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

1997 • 162 citations

Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)

2007 • 162 citations

Increased Iron in the Substantia Nigra Compacta of the MPTP-Lesioned Hemiparkinsonian African Green Monkey: Evidence from Proton Microprobe Elemental Microanalysis

1994 • 138 citations

1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide

2003 • 121 citations

Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis

2005 • 108 citations

Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells

2006 • 106 citations

Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism

2004 • 102 citations

Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6‐OHDA‐lesioned rats

2007 • 97 citations

The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals

1985 • 96 citations

Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain

2004 • 91 citations

Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals.

2002 • 90 citations

Iron Transport Across Biologic Membranes

2009 • 88 citations

Correlation of R2 with total iron concentration in the brains of rhesus monkeys

2005 • 87 citations

The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non‐transferrin‐bound iron uptake

1999 • 84 citations

Implications of alterations in trace element levels in brain in Parkinson's disease and other neurological disorders affecting the basal ganglia.

1993 • 81 citations

Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload

2006 • 80 citations

Distribution of divalent metal transporter-1 in the monkey basal ganglia

2004 • 80 citations

Small-Molecule Screening Identifies the Selanazal Drug Ebselen as a Potent Inhibitor of DMT1-Mediated Iron Uptake

2006 • 76 citations

Divalent metal transporter 1 up‐regulation is involved in the 6‐hydroxydopamine‐induced ferrous iron influx

2007 • 71 citations

Overexpression of Uncoupling Protein 2 in THP1 Monocytes Inhibits β ₂ Integrin-Mediated Firm Adhesion and Transendothelial Migration

2004 • 64 citations

Nonylphenol-induced thymocyte apoptosis involved caspase-3 activation and mitochondrial depolarization

2005 • 63 citations

Iron dysregulation and Parkinson's disease

2005 • 62 citations

Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-κB pathway

2007 • 52 citations

Calcium mediated excitotoxicity in neurofilament aggregate-bearing neurons in vitro is NMDA receptor dependant

2007 • 49 citations

Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra

2007 • 45 citations

Neuroprotective effects of pituitary adenylate cyclase–activating polypeptide (PACAP) in MPP⁺‐induced alteration of translational control in Neuro‐2a neuroblastoma cells

2007 • 41 citations

Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells

1999 • 41 citations

[Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice].

2003 • 40 citations

Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of parkinson’s disease

2003 • 38 citations

Time Dependent Effects of 6-OHDA Lesions on Iron Level and Neuronal Loss in Rat Nigrostriatal System

2004 • 36 citations

Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain

2004 • 23 citations