U‐Shaped dose‐response curves: Their occurrence and implications for risk assessment

The Structure of Scientific Revolutions

1963 • 36,823 citations

The Structure of Scientific Revolutions

1963 • 8,618 citations

A DISTRIBUTION-FREE k-SAMPLE TEST AGAINST ORDERED ALTERNATIVES

1954 • 1,455 citations

Toxic effects of metals

1991 • 1,198 citations

The Essential Trace Elements

1981 • 932 citations

A Prospective Study of Moderate Alcohol Consumption and the Risk of Coronary Disease and Stroke in Women

1988 • 921 citations

A new method for determining allowable daily intakes*1

1984 • 918 citations

Casarett and Doull's toxicology: The basic science of poisons

1987 • 798 citations

The Comparison of Several Dose Levels with a Zero Dose Control

1972 • 704 citations

Hormesis — The stimulation of growth by low levels of inhibitors

1982 • 691 citations

Preliminary Report: Findings from the Aspirin Component of the Ongoing Physicians' Health Study

1988 • 504 citations

Testing the Statistical Certainty of a Response to Increasing Doses of a Drug

1985 • 483 citations

ALCOHOL AND MORTALITY: A U-SHAPED CURVE

1981 • 472 citations

Moderate Alcohol Consumption and the Risk of Breast Cancer

1987 • 450 citations

Alcohol and Coronary Heart Disease

1984 • 369 citations

Advances in Behavioral Pharmacology

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CORONARY HEART DISEASE MORTALITY AND ALCOHOL CONSUMPTION IN FRAMINGHAM

1986 • 351 citations

Alcohol and Hemorrhagic Stroke

1986 • 347 citations

Stroke and Alcohol Consumption

1986 • 336 citations

Relationship Between Childhood Blood Lead Levels and Stature

1986 • 251 citations

Alcohol Consumption and Breast Cancer in the Epidemiologic Follow-up Study of the First National Health and Nutrition Examination Survey

1987 • 249 citations

FREQUENCY OF ALCOHOL CONSUMPTION AND MORBIDITY AND MORTALITY: The Yugoslavia Cardiovascular Disease Study

1980 • 246 citations

ASSOCIATIONS OF SERUM HIGH DENSITY LIPOPROTEIN AND TOTAL CHOLESTEROL WITH TOTAL, CARDIOVASCULAR, AND CANCER MORTALITY IN A 7-YEAR PROSPECTIVE STUDY OF 10 000 MEN

1981 • 216 citations

The toxicity of arsenic and its compounds

1983 • 198 citations

Smoking and weight: the Minnesota Lipid Research Clinic.

1981 • 137 citations

DRINKING AND MORTALITY

1987 • 133 citations

The Occurrence of Chemically Induced Hormesis

1987 • 130 citations

What is there that is not poison? A study of the Third Defense by Paracelsus

1986 • 123 citations

ALCOHOL AND CORONARY HEART DISEASE IN PUERTO RICO

1983 • 120 citations

Delayed behavioral toxicity of lead with increasing exposure concentration

1983 • 118 citations

Prevention of Coronary Heart Disease: Practical Management of the Risk Factors.

1984 • 113 citations

Hormesis: A Response to Low Environmental Concentrations of Petroleum Hydrocarbons

1981 • 111 citations

Blood lead concentration, blood pressure, and renal function.

1984 • 106 citations

Chronic low-level lead toxicity in the rat

1980 • 98 citations

Medicinal arsenic and internal malignancies

1982 • 96 citations

Alcohol and hemorrhagic stroke. The Honolulu Heart Program

1986 • 84 citations

ALCOHOL CONSUMPTION AND BLOOD PRESSURE

1985 • 79 citations

Alcohol and ischaemic heart disease in middle aged British men.

1987 • 68 citations

What is hormesis and why haven't we heard about it before?

1987 • 64 citations

Lead exposure and child development. An international assessment

1989 • 59 citations

The Behavioral Toxicity of Lead: Problems and Perspectives

1984 • 56 citations

Women and alcohol. A review

1986 • 54 citations

Sufficient challenge

1967 • 44 citations

Chronic lead and brain development: Intraocular brain grafts as a method to reveal regional and temporal effects in the central nervous system

1980 • 43 citations

The Contribution of a Moderate Intake of Alcohol to the Presence of Hypertension

1987 • 42 citations

The Tromso heart study: alcoholic beverages and coronary risk factors.

1986 • 41 citations

An experimental approach to the determinants of biological water quality

1979 • 37 citations

Effects of perinatal exposure to methyl mercury on functional brain development and neurochemistry.

1974 • 35 citations

Arsenic Content of Homeopathic Medicines

1986 • 35 citations

Behavioral Toxicology of Volatile Organic Solvents. IV. Comparisons of the Rate-Decreasing Effects of Acetone, Ethyl Acetate, Methyl Ethyl Ketone, Toluene, and Carbon Disulfide on Schedule-Controlled Behavior of Mice

1987 • 32 citations

Metal Interactions in Carcinogenesis: Enhancement, Inhibition

1981 • 25 citations

Use of pharmacological challenges to disclose neurobehavioral deficits.

1983 • 22 citations

Characterization of triethyl lead chloride neurotoxicity in adult rats.

1982 • 19 citations

Perspectives on selenium anticarcinogenicity^†

1986 • 18 citations

Increased body:brain weight ratio in developing rats after low exposure to organic lead

1984 • 18 citations

Postnatal lead exposure and the cholinergic system

1985 • 17 citations

Prenatal exposure to ethanol potentiates morphine-induced hypothermia in adult rats.

1986 • 17 citations

Induction of mucosal glutathione synthesis by arsenic

1980 • 16 citations

Comprehensive neurophysiological evaluation of lead-exposed workers

1983 • 13 citations

Sigmoid Growth and the Assessment of Hormesis

1987 • 11 citations

Drug interactions: the effects of alcohol and meprobamate applied singly and jointly in human subjects. III. The concentrations of alcohol and meprobamate in the blood and their effects on performance; application of mathematical models.

1975 • 11 citations

Detection of the effects of lead exposure by visual evoked response latency

1979 • 10 citations

The Resistance of Fixed Tissue Cells to the Toxic Action of Certain Chemical Substances

1935 • 9 citations

Behavioral Effects following Rehabilitation from Postnatal Exposure to Lead Acetate

1985 • 8 citations

[Sensory neurography, visual and somatosensory evoked potentials (VEP and SEP) in lead-exposed children].

1986 • 8 citations

Increased synthesis of membrane macromolecules is an early response of retinal neurons to trimethyltin intoxication

1986 • 7 citations

Electrophysiological Assessment of Sensory and Cognitive Function in Children Exposed to Lead: A Review

1989 • 5 citations

Overdose toxicity studies versus threshold: elements of biology must be incorporated into risk assessment

1987 • 5 citations

Instability of dose-response results in small sample studies in behavioral teratology.

1982 • 3 citations

Deleted Work

1955 • 0 citations