The role of transacylases in the metabolism of arachidonate and platelet activating factor

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Metabolism of Glycerolipids

1960 • 779 citations

Ether Lipids Chemistry and Biology

1972 • 437 citations

Phospholipid Metabolism in Stimulated Human Platelets

1980 • 367 citations

Metabolism of Molecular Species of Diacylglycerophospholipids

1978 • 331 citations

Phospholipid fatty acid remodeling in mammalian cells

1991 • 297 citations

1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

1984 • 296 citations

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7

1988 • 236 citations

Remodeling of arachidonate-containing phosphoglycerides within the human neutrophil.

1986 • 225 citations

Arachidonoyl transacylase in human platelets. Coenzyme A-independent transfer of arachidonate from phosphatidylcholine to lysoplasmenylethanolamine.

1983 • 195 citations

Activation of a membrane-associated phospholipase A2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate.

1991 • 189 citations

1-ether-linked phosphoglycerides. Major endogenous sources of arachidonate in the human neutrophil.

1988 • 180 citations

1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species.

1984 • 173 citations

Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions.

1985 • 156 citations

Control of arachidonic acid accumulation in bone marrow-derived macrophages by acyltransferases.

1981 • 154 citations

The enzymatic acylation and hydrolysis of lysolecithin

1965 • 148 citations

Platelet-Activating Factor and Related Lipid Mediators

1987 • 147 citations

Mobilization of arachidonic acid in human platelets kinetics and Ca2+ dependency

1977 • 141 citations

Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine.

1984 • 138 citations

N-acylation of ethanolamine phospholipids in canine myocardium

1982 • 138 citations

A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway

1991 • 129 citations

Purification of a phospholipase A2 from human monocytic leukemic U937 cells. Calcium-dependent activation and membrane association.

1990 • 125 citations

Tumor lipids: Metabolic relationships derived from structural analyses of acyl, alkyl, and alk-1-enyl moieties of neutral glycerides and phosphoglycerides

1969 • 123 citations

Transfer of arachidonic acid between phospholipids in rat liver microsomes

1979 • 121 citations

Molecular species of phosphatidylcholine, -ethanolamine, -serine, and -inositol in microsomal and photoreceptor membranes of bovine retina.

1983 • 121 citations

Transacylation of lyso platelet-activating factor and other lysophospholipids by macrophage microsomes. Distinct donor and acceptor selectivities.

1987 • 119 citations

Lysocardiolipin formation and reacylation in isolated rat liver mitochondria

1990 • 118 citations

Evidence for a Mixed Function Oxidase in the Biosynthesis of Ethanolamine Plasmalogens from 1-Alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine

1972 • 116 citations

Acyltransferase-catalyzed cleavage of arachidonic acid from phospholipids and transfer to lysophosphatides in lymphocytes and macrophages.

1982 • 110 citations

Hormonal stimulation of arachidonic release from isolated perfused organs relationship to prostaglandin biosynthesis

1977 • 106 citations

Fatty acid and molecular species compositions of phospholipids and diacylglycerols from rat retinal membranes

1991 • 105 citations

An arachidonoyl (polyenoic)-specific phospholipase A2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells.

1990 • 104 citations

1‐O‐alkyl‐linked phosphoglycerides of human platelets: Distribution of arachidonate and other acyl residues in the ether‐linked and diacyl species

1983 • 102 citations

1-O-Alkyl-2-acyl-sn-glycero-3-phosphocholine: A novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187

1983 • 102 citations

Enzymatic Synthesis of Plasmalogens

1973 • 96 citations

Control of prostanoid synthesis: Role of reincorporation of released precursor fatty acids

1986 • 92 citations

Lysophosphatidylcholine metabolism in the rabbit heart. Characterization of metabolic pathways and partial purification of myocardial lysophospholipase-transacylase.

1982 • 92 citations

Role of triglycerides in endothelial cell arachidonic acid metabolism.

1983 • 92 citations

Biosynthesis of N‐Acylethanolamine Phospholipids by Dog Brain Preparations

1983 • 92 citations

Effects of ethylenic bond position upon acyltransferase activity with isomeric cis-octadecenoyl coenzyme a thiol esters

1969 • 91 citations

Coenzyme A-mediated arachidonic acid transacylation in human platelets.

1984 • 91 citations

Accepton concentration effect in the selectivity of acyl coenzyme A: U aclglycerylphosphorylcholine acyltransferase system in rat liver.

1975 • 90 citations

Release of arachidonic acid from 1-ALKYL-2-ACYL-sn-glycero-3-phosphocholine, a precursor of platelet-activating factor, in sat alveolar macrophages

1984 • 88 citations

Lysophospholipase—transacylase from rat lung: isolation and partial purification

1977 • 85 citations

COA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-0-alkyl-sn-glycero-3-phosphocholine (lyso plateletactivating factor) by macrophage microsomes

1985 • 85 citations

Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product.

1985 • 84 citations

Lysolecithin acyltransferase and lysolecithin: Lysolecithin acyltransferase in adult rat lung alveolar type ii epithelial cells

1979 • 83 citations

Transfer of arachidonic acid to human platelet plasmalogen in response to thrombin

1976 • 81 citations

Mobilization of arachidonic acid between diacyl and ether phospholipids in rabbit alveolar macrophages

1984 • 80 citations

Phospholipid biosynthesis in human platelets. Formation of phosphatidylcholine from 1-acyl lysophosphatidylcholine by acyl-CoA:1-acyl-sn-glycero-3-phosphocholine acyltransferase.

1982 • 76 citations

Rabbit myocardial lysophospholipase-transacylase. Purification, characterization, and inhibition by endogenous cardiac amphiphiles.

1983 • 75 citations

Source of arachidonic acid for prostaglandin synthesis in Madin-Darby canine kidney cells.

1981 • 72 citations

Phospholipid molecular species of frog rod outer segment membranes

1983 • 69 citations

Turnover of arachidonic acid in the major diacyl and ether phospholipids of human platelets.

1985 • 68 citations

Ether lysophospholipid-induced production of platelet-activating factor in human polymorphonuclear leukocytes

1990 • 65 citations

N-acylation of dog heart ethanolamine phospholipids by transacylase activity

1983 • 63 citations

Acyltransferase‐catalyzed cleavage of arachidonic acid from phospholipids and transfer to lysophosphatides in macrophages derived from bone marrow Comparison of different donor‐ and acceptor substrate combinations

1984 • 62 citations

Metabolic behavior of acetyl glyceryl ether phosphorylcholine on interaction with rabbit platelets

1983 • 62 citations

Metabolic Fate of Lysolecithin Injected into Rats

1972 • 62 citations

Arachidonyl transfer from diacyl phosphatidylcholine to ether phospholipids in rat platelets

1984 • 62 citations

Involvement of triacylglycerol in the metabolism of fatty acids by cultured neuroblastoma and glioma cells

1982 • 61 citations

Characterization of CoA-independent transacylase activity in U937 cells

1991 • 61 citations

Selective acyl transfer in the reacylation of brain glycerophospholipids. Comparison of three acylation systems for 1-alk-1′-enylglycero-3-phosphoethanolamine, 1-acylglycero-3-phosphoethanolamine and 1-acylglycero-3-phosphocholine in rat brain microsomes

1989 • 60 citations

The molecular species composition of diacyl-, alkylacyl- and alkenylacylglycerophospholipids in rabbit alveolar macrophages. High amounts of 1-O-hexadecyl-2-arachidonyl molecular species in alkylacylglycerophosphocholine

1985 • 56 citations

Coenzyme A-dependent transacylation system in rabbit liver microsomes.

1988 • 55 citations

Selective deacylation of arachidonate-containing ethanolamine-linked phosphoglycerides in stimulated human neutrophils.

1990 • 54 citations

Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human promyelocytic leukemic HL60 cells. Stimulated expression of phospholipase A2 and acetyltransferase requires differentiation.

1986 • 52 citations

Arachidonate mobilization in diacyl, alkylacyl and alkenylacyl phospholipids on stimulation of rat platelets by thrombin and the Ca2+ ionophore A23187

1986 • 51 citations

Phospholipid Remodeling in Human Neutrophils

1989 • 51 citations

Incorporation of arachidonic acid into 1-acyl-2-lyso-sn-glycero-3-phosphocholine of the human neutrophil

1987 • 50 citations

On the anabolism of lysolecithin

1965 • 50 citations

Incorporation and redistribution of arachidonic acid in diacyl and ether phospholipids of bovine aortic endothelial cells

1986 • 50 citations

Induction by lysophospholipids of CoA-dependent arachidonyl transfer between phospholipids in rat platelet homogenates

1984 • 50 citations

Cytosolic lysophospholipase in cardiac myocytes and its inhibition by L-palmitoyl carnitine

1984 • 48 citations

Stimulated production and natural occurrence of 1,2-diarachidonoylglycerophosphocholine in human neutrophils

1987 • 48 citations

Acyltransferase Activity to 1-O-Alkyl-Glycero-3-phosphorylcholine in Sarcoplasmic Reticulum

1970 • 47 citations

Lysophospholipase and lysophosphatidylcholine:Lysophosphatidylcholine transacylase from rat lung: Evidence for a single enzyme and some aspects of its specificity

1978 • 46 citations

Possible identity of lysolecithin acyl-hydrolase with lysolecithin-lysolecithin acyl-transferase in rat-lung soluble fraction

1974 • 46 citations

Specificity of acyl-CoA:phospholipid acyltransferases: solvent and temperature effects

1968 • 45 citations

Lysophosphatidylcholine as an intermediate in phosphatidylcholine metabolism and glycerophosphocholine synthesis in cultured cells: an evaluation of the roles of 1-acyl- and 2-acyl-lysophosphatidylcholine

1989 • 44 citations

Stimulation of prostaglandin synthesis in WI-38 human lung fibroblasts following inhibition of phospholipid acylation by p-hydroxymercuribenzoate

1984 • 44 citations

Purification and properties of acyl-CoA: 1-acyl-sn-glycero-3-phosphocholine-O-acyltransferase from bovine brain microsomes

1986 • 44 citations

Acylation of 1-alkenyl-glycerophosphocholine and 1-acyl-glycerophosphocholine in guinea pig heart

1986 • 44 citations

Selectivity of acyl transfer between phospholipids: Arachidonoyl transacylase in dog heart membranes

1985 • 41 citations

Transacylation of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-sn-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6ω3)

1985 • 41 citations

Metabolism of unique diarachidonoyl and linoleoylarachidonoyl species of ethanolamine and choline phosphoglycerides in rat testes

1985 • 40 citations

Ionophore-induced metabolism of phospholipids and eicosanoid production in porcine aortic endothelial cells: selective release of arachidonic acid from diacyl and ether phospholipids

1987 • 40 citations

CoA‐Dependent cleavage of arachidonic acid from phosphatidylcholine and transfer to phosphatidylethanolamine in homogenates of murine thymocytes

1981 • 40 citations

Selective Transacylation of 1‐O‐Alkylglycerophosphoethanolamine by Docosahexaenoate and Arachidonate in Rat Brain Microsomes

1987 • 39 citations

Effect of a fish oil diet on the composition of rat neutrophil lipids and the molecular species of choline and ethanolamine glycerophospholipids.

1989 • 39 citations

Differentiation between acyl coenzyme A:lysophosphatidylcholine acyltransferase and lysophosphatidylcholine: lysophosphatidylcholine transacylase in the synthesis of dipalmitoylphosphatidylcholine in rat lung.

1980 • 38 citations

Properties of canine myocardial phosphatidylethanolamine N-acyltransferase

1984 • 38 citations

The enzymic incorporation of arachidonic acid into ether-containing choline and ethanolam1ne phosphoglycerides by deacylation-acylat1on reactions

1973 • 37 citations

Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages

1986 • 37 citations

The role of cardiolipin as an acyl donor in dog heart n-acylethanolamine phospholipid biosynthesis

1983 • 36 citations

Acylation of lysophosphatidylcholine in bovine heart muscle microsomes: Purification and kinetic properties of acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

1988 • 35 citations

Relative degradation of different arachidonoyl molecular species of choline glycerophospholipids in opsonized zymosan-stimulated rabbit alveolar macrophages

1986 • 35 citations

Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: Comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors

1979 • 35 citations

Regulation of the Fatty Acid Composition of Alkyl Ether Phospholipid in Ehrlich Ascites Tumor Cells

1977 • 34 citations

Metabolic pathways of lysolecithn in a soluble rat-liver system

1958 • 33 citations

Biosynthesis of choline plasmalogens in neonatal rat myocytes

1991 • 33 citations

Lysophospholipase and transacylase activities of rat gastric mucosa

1979 • 32 citations

Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes

1986 • 31 citations

Triacylglycerol as a precursor in phospholipid biosynthesis in cultured neuroblastoma cells: studies with labeled glucose, fatty acid, and triacylglycerol

1985 • 31 citations

Turnover of eicosanoid precursor fatty acids among phospholipid classes and subclasses of cultured human umbilical vein endothelial cells

1989 • 31 citations

Metabolism of phosphatidylglycerol and bis(monoacylglycero)-phosphate in macrophage subcellular fractions.

1990 • 31 citations

Altered acyl chain compositions of alkylacyl, alkenylacyl, and diacyl subclasses of choline and ethanolamine glycerophospholipids in rat heart by dietary fish oil

1989 • 30 citations

Lysolecithin:Lysolecithin acyltransferase from rabbit lung: Enzymatic properties and kinetic study

1982 • 29 citations

Turnover Rates of the Molecular Species of Ethanolamine Plasmalogen of Rat Brain

1984 • 29 citations

On the mechanism of action of lysophospholipase-transacylase from rat lung

1979 • 29 citations

Acyltransferase Activity to 1-Acyl-, 1-O-Alkenyl-, and 1-O-Alkyl-glycero-3-phosphorylcholine in Ehrlich Ascites Tumor Cells

1972 • 29 citations

Regulation of intracellular arachidonate in normal and stressed endothelial cells

1984 • 28 citations

Highly unsaturated phospholipid molecular species of rat erythrocyte membranes: Selective incorporation of arachidonic acid into phosphoglycerides containing polyunsaturation in both acyl chains

1986 • 28 citations

The acylation of 1-acyl sn-glycero-3-phosphorylcholine by glial and neuronal nuclei and derived neuronal unclear envelopes: a comparison of unclear and microsomal membranes

1981 • 27 citations

Substrate specificity of lysophospholipase-transacylase from rat lung and its action on various physical forms of lysophosphatidylcholine

1981 • 26 citations

Studies on the incorporation and transacylation of various fatty acids in choline and ethanolamine-containing phosphoacyglycerol subclasses in human neutrophils

1989 • 26 citations

Lysophosphatidylcholine acyltransferase and lysophosphatidylcholine: lysophosphatidylcholine acyltransferase in alveolar type II cells from fetal rat lung

1985 • 25 citations

Arachidonic Acid Incorporation and Redistribution in Human Neuroblastoma (SK‐N‐BE) Cell Phospholipids

1990 • 25 citations

Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor

1985 • 25 citations

Effects of eicosapentaenoic and docosahexaenoic acid supplements on phospholipid composition and plasmalogen biosynthesis in P388D1 cells

1989 • 25 citations

Phosphatidylcholine formation from exogenous lysophosphatidylcholine in isolated hamster heart

1982 • 25 citations

Cellular distribution of enzymes involved in phosphatidylcholine synthesis in developing rat lung

1983 • 23 citations

Selective acylation of alkyllysophospholipids by docosahexaenoic acid in Ehrlich ascites cells.

1986 • 23 citations

N-Acylation of ethanolamine phospholipids by acyl transfer does not involve hydrolysis

1987 • 22 citations

Coenzyme A-dependent and -independent acyl transfer between dog heart microsomal phospholipids

1986 • 22 citations

Selective acylation of alkyllysophospholipids by docosahexaenoic acid in Ehrlich ascites cells

1986 • 22 citations

Formation of bis(monoacylglycero)phosphate by a macrophage transacylase

1989 • 21 citations

Heterogeneity in the metabolism of the arachidonoyl molecular species of glycerophospholipids of rabbit alveolar macrophages

1985 • 21 citations

Mechanism of lysophosphatidylcholine accumulation in the ischemic canine heart

1990 • 20 citations

sn-Glycerol-3-phosphate transacylase activity in Euglena gracilis organelles

1976 • 19 citations

Selective utilization of palmitoyl lysophosphatidylcholine in the synthesis of disaturated phosphatidylcholine in rat lung

1981 • 18 citations

Coenzyme A-dependent, ATP-independent acylation of 2-acyl lysophosphatidylinositol in rat liver microsomes

1991 • 17 citations

Phospholipid (diacyl, alkylacyl, alkenylacyl) and fatty acyl chain composition in murine mastocytoma cells.

1985 • 17 citations

Transfer of arachidonate from phosphatidylcholine to phosphatidylethanolamine and triacylglycerol in guinea pig alveolar macrophages

1986 • 15 citations

Very high proportion of disaturated molecular species in rat platelet diacyl-glycerophosphocholine: Involvement of CoA-dependent transacylation reactions

1990 • 14 citations

Acylation of 1-alkenylglycerophosphoethanolamine and 1-acylglycerophosphoethanolamine in guinea-pig heart microsomes

1987 • 14 citations

Effect of lipids on activity and conformation of lysolecithin:lysolecithin acyltransferase from rabbit lung

1984 • 13 citations

Lysolecithin:lysolecithin acyltransferase from rabbit lung.

1984 • 13 citations

Formation of acylphosphatidylglycerol by a lysosomal phosphatidylcholine: bis(monoacylglycero)phosphate acyl transferase

1990 • 13 citations

Arachidonic acid mobilization among phospholipids in murine mastocytoma P-815 cells: role of ether-linked phospholipids.

1990 • 12 citations

Acylation of dog heart lysophosphatidylserine by transacylase activity

1987 • 12 citations

Acylation of 1-alkyl- and 1-acyl-lysophospholipids by rat platelets

1986 • 12 citations

The thrombin-dependent enrichment of alkenylacyl ethanolamine phosphoglyceride with [¹⁴C]eicosapentaenoic and [³H]arachidonic acids in prelabelled human platelets

1987 • 9 citations

Effects of a fish oil diet on the metabolism of endogenous (n−6) and (n−3) fatty acids in rat neutrophils

1990 • 9 citations

Essential histidine residues in lysolecithin:lysolecithin acyltransferase from rabbit lung

1989 • 9 citations

Comparison of acyl-CoA : Lysophosphatidylcholine acyltransferase and lysophosphatidylcholine : Lysophosphatidylcholine transacylase activity in various mammalian lungs

1981 • 9 citations

Effect of albumin on acyl-CoA: lysolecithin acyltransferase, lysolecithin : lysolecithin acyltransferase and acyl-CoA hydrolase from rabbit lung

1990 • 9 citations

Ca2+ effect on ATP-independent lysophospholipid transacylases is indissociable from Ca2+ effect on phospholipase A2 activity in rat platelet sonicates

1988 • 6 citations

1-acyl-2-lysophosphatidylcholine: phosphatidylglycerol-2-acyltransacylase in lung microsomes and type ii pneumocyte-derived cultures

1981 • 6 citations

Substrate selectivity of lysophosph atidylcholine: Lysophosph atidylcholine acyltransferase from rabbit lung

1984 • 6 citations

Purification of lysophosphatidylcholine transacylase from bovine heart muscle microsomes and regulation of activity by lipids and coenzyme A

1989 • 6 citations

Acylation of alkyllysophospholipids by Fischer sarcoma microsomes

1991 • 5 citations

Arachidonic acid transfer from diacyl-SN-glycero-3-phosphocholine to ether phospholipids in rat peripheral blood lymphocytes

1987 • 5 citations

Theoretical approach to the steady-state kinetics of a bi-substrate acyl-transfer enzyme reaction that follows a hydrolysable-acyl-enzyme-based mechanism. Application to the study of lysophosphatidylcholine:lysophosphatidylcholine acyltransferase from rabbit lung

1990 • 4 citations

Chemical mechanism of lysophosphatidylcholine: lysophosphatidylcholine acyltransferase from rabbit lung. pH-dependence of kinetic parameters

1990 • 4 citations

Essential residues in lysolecithin:lysolecithin acyltransferase from rabbit lung: Assessment by chemical modification

1990 • 3 citations