Melatonin: Parallels in pineal gland and retina

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES¹

1958 • 1,634 citations

The Pineal and Its Hormones in the Control of Reproduction in Mammals*

1980 • 1,243 citations

PARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESS

1969 • 1,156 citations

The Vertebrate Eye and Its Adaptive Radiation

1943 • 1,032 citations

Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N -Acetyltransferase

1970 • 748 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity

1974 • 682 citations

Rod Outer Segment Disk Shedding in Rat Retina: Relationship to Cyclic Lighting

1976 • 665 citations

Radioimmunoassay of Serum Concentrations of Melatonin in Sheep Exposed to Different Lighting Regimens

1976 • 643 citations

Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus

1979 • 582 citations

The development, topographical relations and innervation of the epiphysis cerebri in the albino rat

1960 • 566 citations

Melatonin is a potent modulator of dopamine release in the retina

1983 • 507 citations

Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor

1967 • 463 citations

Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina.

1983 • 450 citations

STRUCTURE OF MELATONIN¹

1959 • 443 citations

Enzymatic O-Methylation of N-Acetylserotonin to Melatonin

1960 • 427 citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

1985 • 415 citations

Control of Hydroxyindole O-Methyltransferase Activity in the Rat Pineal Gland by Environmental Lighting

1965 • 381 citations

Light dependent phosphorylation of rhodopsin by ATP

1972 • 370 citations

The Fate of Melatonin in Animals

1961 • 341 citations

Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.

1983 • 331 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

Melatonin Synthesis in the Pineal Gland: Effect of Light Mediated by the Sympathetic Nervous System

1964 • 284 citations

Retinal rhythms in chicks: circadian variation in melantonin and serotonin N-acetyltransferase activity.

1980 • 281 citations

Circadian regulation of retinomotor movements. I. Interaction of melatonin and dopamine in the control of cone length.

1985 • 274 citations

Methoxyindoles and Photoreceptor Metabolism: Activation of Rod Shedding

1983 • 265 citations

Biosynthesis of melatonin: enzymic conversion of serotonin to N-acetylserotonin

1960 • 256 citations

Atypical Synergisticα₁- andβ-Adrenergic Regulation of Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′- Monophosphate in Rat Pinealocytes

1985 • 256 citations

Retinal and pineal hydroxyindole-o-methyl transferase activity in vertebrates

1965 • 243 citations

The Epiphyseal Cell: an Electron-microscopic Study of its Intercellular Relationships and Intracellular Morphology in the Pineal Body of the Albino Rat

1965 • 238 citations

Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic→ spinal cord circuit in the melatonin rhythm generating system

1983 • 236 citations

Retinal S Antigen Identified as the 48K Protein Regulating Light-Dependent Phosphodiesterase in Rods

1985 • 234 citations

Specific Binding of Melatonin in Bovine Brain*

1979 • 218 citations

Melatonin Synthesis: Adenosine 3′,5′-Monophosphate and Norepinephrine Stimulate N -Acetyltransferase

1970 • 218 citations

The distribution of taurine in the vertebrate retina

1976 • 216 citations

MODE OF ACTION OF PINEAL NERVE FIBERS IN FROGS

1962 • 215 citations

A Specific Radioimmunoassay for Melatonin in Biological Tissue and Fluids and its Validation by Gas Chromatography-Mass Spectrometry

1977 • 201 citations

Melatonin Synthesis by the Retina

1979 • 184 citations

Retinal degeneration in cats fed casein. I. Taurine deficiency.

1976 • 179 citations

Free amino acids of chicken and rat retina

1972 • 176 citations

Differential localization of N-acetylated indolealkylamines in CNS and the Harderian gland using immunohistology

1976 • 174 citations

ULTRASTRUCTURAL LOCALIZATION OF RHODOPSIN IN THE VERTEBRATE RETINA

1974 • 172 citations

Rhythms in immunoreactive melatonin in the retina and harderian gland of rats: Persistence after pinealectomy

1983 • 168 citations

PINEALECTOMY ABOLISHES PLASMA MELATONIN IN THE RAT

1980 • 161 citations

Immunohistochemical evidence for the presence of melatonin in the pineal gland, the retina and the Harderian gland

1981 • 160 citations

Adenyl Cyclase Activity in Rat Pineal Gland: Effects of Chronic Denervation and Norepinephrine

1967 • 155 citations

Role of Cyclic AMP in Mediating the Effects of MSH, Norepinephrine, and Melatonin on Frog Skin Color

1969 • 155 citations

Pineal and Retinal Relationships

1986 • 154 citations

Retinal Localization of the Hydroxyindole-O-methyl Transferase (HIOMT) in the Rat

1971 • 154 citations

THE UPTAKE OF H3-MELATONIN IN ENDOCRINE AND NERVOUS TISSUES AND THE EFFECTS OF CONSTANT LIGHT EXPOSURE.

1964 • 154 citations

Evidence for a cytoplasmic melatonin receptor

1978 • 153 citations

STIMULATION OF C ¹⁴ -MELATONIN SYNTHESIS FROM C ¹⁴ -TRYPTOPHAN BY NORADRENALINE IN RAT PINEAL IN ORGAN CULTURE

1969 • 153 citations

Immunohistological localization of N-acetylindolealkylamines in pineal gland, retina and cerebellum

1974 • 151 citations

Binding of Melatonin to Human and Rat Plasma Proteins

1972 • 149 citations

Melatonin in the retina and the harderian gland. Ontogeny, diurnal variations and melatonin treatment

1978 • 148 citations

Presence of Melatonin in Plasma and Urine of Pinealectomized Rats¹

1976 • 145 citations

The third eye

1973 • 136 citations

Regional Uptake of 3H-Melatonin from Blood or Cerebrospinal Fluid by Rat Brain

1969 • 135 citations

Hydroxyindole—O—Methyl Transferases in Rat Pineal, Retina and Harderian Gland

1972 • 135 citations

Visual Pathway Mediating Pineal Response to Environmental Light

1967 • 133 citations

N-acetyltransferase activity responds to environmental lighting in the eye as well as in the pineal gland

1979 • 130 citations

Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin.

1975 • 129 citations

Melatonin receptors in brain

1979 • 126 citations

MELATONIN IN THE RETINA OF RATS: A DIURNAL RHYTHM

1980 • 126 citations

Regulation of indoleamine N-Acetyltransferase activity in the retina: Effects of light and dark, protein synthesis inhibitors and cyclic nucleotide analogs

1983 • 123 citations

Transport of Albumin‐bound Melatonin Through the Blood‐Brain Barrier

1980 • 122 citations

Melatonin: Current Status and Perspectives

1981 • 121 citations

Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea-pigs,Cavia porcellus

1979 • 120 citations

Circadian rhythmicity of the activity of hydroxyindole-o-methyl transferase (HIOMT) in the formation of melatonin and 5-methoxytryptophol in the pineal, retina, and harderian gland of the golden hamster

1980 • 116 citations

Morphologic evidence of photoreceptor differentiation of pinealocytes in the neonatal rat.

1975 • 113 citations

Rhodopsin Kinase Activity in the Mammalian Pineal Gland and Other Tissues

1984 • 109 citations

Studies on the distribution of taurine and other neuroactive amino acids in the retina

1977 • 107 citations

Structure and Function of the Epiphysis Cerebri

1965 • 104 citations

An ultrastructural study of nutritionally induced and reversed retinal degeneration in cats.

1975 • 104 citations

Metabolism of serotonin by the rat retina in vitro

1971 • 101 citations

A sensitive assay for 5-hydroxytryptophan decarboxylase

1964 • 99 citations

Light- and electron-microscopic demonstration of immunoreactive opsin in the pinealocytes of various vertebrates

1981 • 99 citations

INCREASE IN THE LEVEL OF RETINAL MELATONIN AND PERSISTENCE OF ITS DIURNAL RHYTHM IN RATS AFTER PINEALECTOMY

1981 • 98 citations

Characterization of the day-night variation of retinal melatonin content in the chick.

1983 • 97 citations

Light stimulated release of [35S]taurine from chicken retina

1973 • 97 citations

Characterization, Localization, and Biosynthesis of an Interstitial Retinol‐Binding Glycoprotein in the Human Eye

1984 • 97 citations

Localization of hydroxyindole-O-methyltransferase in the mammalian pineal gland and retina.

1985 • 97 citations

FURTHER OBSERVATIONS ON THE FINE STRUCTURE OF THE PARIETAL EYE OF LIZARDS

1960 • 96 citations

Opsin-like immunoreaction in the retinae and pineal organs of four mammalian species

1985 • 95 citations

Localization of rhodopsin antibody in the retina of the frog

1969 • 93 citations

Cyclitols and Phosphoinositides

1978 • 92 citations

Quantitation of the uptake of indoleamines and dopamine in the rabbit retina

1978 • 87 citations

Fine Structure of the Retina in the Reptilian Third Eye

1959 • 86 citations

Cyclic Adenosine Monophosphate: Stimulation of Melatonin and Serotonin Synthesis in Cultured Rat Pineals

1969 • 85 citations

Pineal reactivity of anti-retina sera.

1977 • 85 citations

Kinetic analysis of amino acid uptake by the rat retina in vitro.

1973 • 80 citations

PHOTOSENSITIVITY OF A LOCALIZED REGION OF THE FROG DIENCEPHALON

1963 • 79 citations

Phagocytic Activity of Cultured Retinal Pigment Epithelial Cells from Chick Embryo: Inhibition by Melatonin and Cyclic AMP, and Its Reversal by Taurine and Cyclic GMP

1983 • 78 citations

Characterization of transducin from bovine retinal rod outer segments. The role of sulfhydryl groups.

1984 • 78 citations

The synthesis of melatonin by the trout retina

1978 • 78 citations

Dopamine release induced by electrical field stimulation of rat hypothalamus invitro: Inhibition by melatonin

1982 • 78 citations

Effects of Melatonin on Neurotransmitter Uptake and Release by Synaptosome-Rich Homogenates of the Rat Hypothalamus

1975 • 75 citations

Structure-activity relationships of melatonin and related indoleamines

1975 • 74 citations

Melatonin assays in body fluids.

1978 • 74 citations

Melatonin in the chicken brain: Its origin, diurnal variation, and regional distribution

1974 • 72 citations

Pineal, retinal and harderian gland melatonin in a diurnal species, the richardson's ground squirrel (Spermophilus richardsonii)

1981 • 69 citations

Persistence of Circadian Rhythms of Melatonin and N-Acetylserotonin in the Serum of Rats after Pinealectomy

1981 • 69 citations

Rod outer segments elongate in constant light: Darkness is required for normal shedding

1978 • 66 citations

Fate of Intracisternally Injected Melatonin in the Rat Brain

1973 • 66 citations

Action and localization of glycine and taurine in the cat retina.

1985 • 65 citations

Cytological aspects of pineal development in rats and hamsters

1973 • 65 citations

Studies on the hormonal control of circadian outer segment disc shedding in the rat retina.

1978 • 62 citations

Rôle de l'épiphyse dans la migration du pigment épithélial rétinien chez quelques Téléostéens

1976 • 61 citations

Melatonin-binding in the frog retina: autoradiographic and biochemical analysis.

1986 • 60 citations

Chapter 6 Interphotoreceptor retinol-binding protein: A possible role in retinoid transport to the retina

1983 • 56 citations

Mechanism and specificity of rhodopsin phosphorylation

1975 • 55 citations

Pineal and serum melatonin at midday and midnight following pinealectomy or castration in male rats

1975 • 55 citations

Diurnal variations of melatonin and N-acetylserotonin in the tissues of quails (Coturnix sp.), pigeons (Columba livia), and chickens (Gallus domesticus)

1983 • 55 citations

INTERACTION OF α-MELANOCYTE-STIMULATING HORMONE, MELATONIN, CYCLIC AMP AND CYCLIC GMP IN THE CONTROL OF MELANOGENESIS IN HAIR FOLLICLE MELANOCYTES IN VITRO

1981 • 54 citations

Light stimulates the incorporation of inositol into phosphatidylinositol in the retina

1981 • 54 citations

N-acetyltryptamine antagonizes the melatonin-induced inhibition of [3H]dopamine release from retina

1984 • 53 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision

1981 • 53 citations

The pineal gland does not control rod outer segment shedding and phagocytosis in the rat retina and pigment epithelium.

1978 • 53 citations

THE ACTION OF MELATONIN ON SINGLE AMPHIBIAN PIGMENT CELLS IN TISSUE CULTURE

1977 • 47 citations

Light Regulation of Rat Retinal Hydroxyindole—O—Methyl Transferase (HIOMT) Activity

1972 • 46 citations

Pineal Gland: Dibutyryl Cyclic Adenosine Monophosphate Stimulation of Labeled Melatonin Production

1970 • 45 citations

Retinal and Pineal Hydroxyindole—O—Methyl Transferases in the Rat: Changes Following Cervical Sympathectomy, Pinealectomv or Blinding

1973 • 44 citations

Taurine et acides amin?s dans la r?tine des animaux

1958 • 44 citations

Indoleamine‐Sensitive Adenylate Cyclase in Rabbit Retina: Characterization and Distribution

1985 • 43 citations

Light Enhances the Turnover of Phosphatidylinositol in Rat Retinas

1983 • 43 citations

6-Methoxy-tetrahydro-β-carboline and melatonin in the human retina

1984 • 43 citations

Localization of a Uveitogenic Soluble Retinal Antigen in the Normal Guinea Pig Eye by an Indirect Fluorescent Antibody Technique

1973 • 43 citations

Effects of time, photoperiod, and pinealectomy on ocular and plasma melatonin concentrations in the chick

1985 • 39 citations

Tentative immunohistochemical demonstration of melatonin in the rat pineal gland

1977 • 39 citations

Light-Induced Changes in Pineal Hydroxyindole- O -Methyltransferase: Abolition by Lateral Hypothalamic Lesions

1966 • 37 citations

Nonpineal Melatonin in the Alligator ( Alligator mississippiensis )

1980 • 37 citations

Binding Sites for Melatonin in Bovine Pineal Gland

1980 • 36 citations

Studies on hydroxyindole-O-methyltransferase in frog brain and retina: enzymology, regional distribution and environmental control of enzyme levels.

1975 • 36 citations

Phosphoinositide Metabolism in the Retina: Localization to Horizontal Cells and Regulation by Light and Divalent Cations

1983 • 36 citations

Diurnal rhythms of immunoreactive N-acetylserotonin and melatonin in the serum of male rats

1980 • 36 citations

Ultrastructure of Pineal Eye Sensory Cells

1959 • 35 citations

Morphologic evidence for differentiation of pinealocytes from photoreceptor cells in the adult noctule bat (Nyctalus noctula, Schreber)

1977 • 35 citations

Melatonin in the human retina

1984 • 34 citations

Properties of the parietal eye of the green iguana

1968 • 34 citations

Effect of photic manipulation on the level of melatonin in the retinas of frogs (Rana tigrina regulosa)

1985 • 33 citations

Taurine: Stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism

1979 • 33 citations

Pineal N-acetyltransferase Activity in Blinded and Anosmic Male Rats12

1971 • 32 citations

Hydroxyindole- O -Methyl-Transferase Activity: Effect of Sympathetic Nerve Stimulation

1968 • 31 citations

Free amino acids in the pineal and pituitary glands of human brain

1970 • 30 citations

Abundance of cystathionine in the pineal body. Free amino acids and related compounds of bovine pineal, anterior and posterior pituitary, and brain

1968 • 29 citations

Retinal degeneration; Experimental and clinical studies

1986 • 27 citations

Morphological and Functional Comparison between the Retina and the Pineal Organ of Lower Vertebrates

1979 • 27 citations

Effect of Light and Darkness on the in vitro Release of N-Acetylserotonin and Melatonin by the Retina of Guinea Pigs

1982 • 26 citations

Uptake of taurine by retina in different species

1978 • 25 citations

Ocular distribution of hydroxyindole-O-methyl transferase (HIOMT) in the duck (Anas platyrhinchos)

1972 • 24 citations

Les pinéalocytes de mammifère: diversité, homologies, origine. Etude chez la taupe adulte (Talpa europaea L.)

1976 • 24 citations

Melatonin and Pigment Cell Rhythmicity

1981 • 23 citations

Determination of bovine retinal melatonin with HPLC-EC

1985 • 21 citations

Circadian change in rat pineal tryptophan content: lack of correlation with serum tryptophan

1979 • 21 citations

A Third Eye

1970 • 21 citations

Opsin-immunoreactive outer segments of photoreceptors in the eye and in the lumen of the optic nerve of the hagfish, Myxine glutinosa

1984 • 21 citations

Day-night rhythm in plasma melatonin in a mammal lacking a distinct pineal gland, the nine-banded armadillo

1981 • 20 citations

Evidence Against Dopaminergic and Further Support For α‐Adrenergic Receptor Involvement in the Pineal Pho sphatidy lino sitol Effect

1980 • 20 citations

Characteristics and non-rhythmicity of retinal hydroxyindole-O-methyltransferase activity in trout (Salmo gairdneri)

1984 • 19 citations

Circadian rhythm and uptake of taurine by the rat pineal gland

1978 • 18 citations

Inositol incorporation into phosphoinositides in retinal horizontal cells of Xenopus laevis: enhancement by acetylcholine, inhibition by glycine.

1984 • 17 citations

Cyclic AMP-induced release of [14C]taurine from pinealocytes

1979 • 13 citations

Frog pineal photoreceptor renewal: Preliminary observations

1971 • 8 citations

This pineal gland does not mediate phase shifts in the disc shedding rhythm of the rat retina.

1982 • 5 citations

NATURE OF THE RECEPTORS WHICH MEDIATE ENHANCED PHOSPHATIDYLINOSITOL TURNOVER IN RAT PINEAL GLAND

1978 • 4 citations

STRUCTURE OF TRANSDUCIN AND ITS RELATIONSHIP TO CELLULAR GUANINE NUCLEOTIDE-BINDING PROTEINS

1986 • 2 citations