Dose escalation safety and tolerance study of the N-methyl-d-aspartate antagonist dextromethorphan in neurosurgery patients

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Clinical Experience With Excitatory Amino Acid Antagonist Drugs

1995 • 499 citations

Changes in Amino Acid Neurotransmitters and Cerebral Blood Flow in the Ischemic Penumbral Region following Middle Cerebral Artery Occlusion in the Rat: Correlation with Histopathology

1993 • 220 citations

Safety and Tolerability of the Glutamate Antagonist CGS 19755 (Selfotel) in Patients With Acute Ischemic Stroke

1995 • 206 citations

Safety, Tolerability, and Pharmacokinetics of the N -Methyl- <scp>d</scp> -Aspartate Antagonist Dextrorphan in Patients With Acute Stroke

1995 • 194 citations

Pharmacology of cerebral ischemia

1995 • 163 citations

Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity

1987 • 163 citations

Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.

1987 • 154 citations

Dextromethorphan reduces neocortical ischemic neuronal damage in vivo

1988 • 131 citations

Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits.

1988 • 115 citations

Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia

1988 • 102 citations

Dextromethorphan protects against cerebral infarction in a rat model of hypoxia-ischemia

1988 • 92 citations

Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

1987 • 91 citations

High‐dose dextromethorphan in amyotrophic lateral sclerosis: Phase I safety and pharmacokinetic studies

1994 • 70 citations

Tolerability of Oral Dextromethorphan in Patients with a History of Brain Ischemia

1992 • 61 citations

Protection after Transient Focal Cerebral Ischemia by the N-Methyl-d-Aspartate Antagonist Dextrorphan is Dependent upon Plasma and Brain Levels

1991 • 60 citations

Neuroprotection following focal cerebral ischaemia with the NMDA antagonist dextromethorphan, has a favourable dose response profile

1993 • 50 citations

The Polymorphic Metabolism of Dextromethorphan

1987 • 48 citations

Safety and tolerance of oral dextromethorphan in patients at risk for brain ischemia.

1991 • 47 citations

An Open Label Trial of Dextromethorphan in Huntingtonʼs Disease

1989 • 42 citations

Profiles of extracellular amino acid changes in focal cerebral ischaemia: Effects of mild hypothermia

1993 • 41 citations

Dextromethorphan attenuates post-ischemic hypoperfusion following incomplete global ischemia in the anesthetized rat

1989 • 32 citations

Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia

1991 • 32 citations

Effects of dextromethorphan on rat brain during ischemia and reperfusion assessed by magnetic resonance spectroscopy.

1991 • 28 citations