The Nitric Oxide hypothesis and the hyperdynamic circulation in cirrhosis

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Peripheral arterial vasodilation hypothesis: A proposal for the initiation of renal sodium and water retention in cirrhosis

1988 • 1,606 citations

The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway

1992 • 654 citations

Hyperdynamic circulation in cirrhosis: a role for nitric oxide?

1991 • 627 citations

THE CARDIAC OUTPUT AT REST IN LAENNEC'S CIRRHOSIS 1

1953 • 570 citations

Circulatory changes in chronic liver disease

1958 • 508 citations

Increased serum nitrite and nitrate levels in patients with cirrhosis: Relationship to endotoxemia

1993 • 500 citations

Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis

1988 • 430 citations

Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

1993 • 402 citations

Nitric oxide as a signal in blood vessels

1992 • 285 citations

Use of a tourniquet to prolong the effect of penicillin.

1947 • 264 citations

Hepatic hemodynamics and the renin-angiotensin-aldosterone system in cirrhosis

1980 • 259 citations

Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition

1992 • 258 citations

Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension

1992 • 240 citations

Plasma Volume in Cirrhosis of the Liver: Its Relation of Portal Hypertension, Ascites, and Renal Failure*

1967 • 226 citations

Regulation of Vascular Homeostasis by Nitric Oxide

1993 • 224 citations

Systemic and regional hemodynamics in patients with liver cirrhosis and ascites with and without functional renal failure

1989 • 223 citations

Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats

1993 • 218 citations

RELATION OF RENAL IMPAIRMENT AND HAEMORRHAGIC DIATHESIS TO ENDOTOXAEMIA IN FULMINANT HEPATIC FAILURE

1974 • 213 citations

General and regional circulatory alterations in cirrhosis of the liver

1964 • 204 citations

Pathogenesis of arterial hypotension in cirrhotic rats with ascites: Role of endogenous nitric oxide

1992 • 190 citations

Hemodynamic and humoral changes after liver transplantation in patients with cirrhosis

1993 • 187 citations

Nitric oxide and cardiovascular control

1993 • 178 citations

Systemic and Renal Hemodynamics in Oliguric Hepatic Failure: Effect of Volume Expansion*

1967 • 173 citations

Transjugular intrahepatic portosystemic shunt worsens the hyperdynamic circulatory state of the cirrhotic patient: Preliminary report of a prospective study†

1994 • 159 citations

The Role of Nitric Oxide in Endotoxic Shock: Effects of NG-Monomethyl-L-Arginine

1992 • 157 citations

Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses

1990 • 155 citations

Brachial and femoral artery blood flow in cirrhosis: relationship to kidney dysfunction.

1993 • 146 citations

Vasodilatation and sodium retention in prehepatic portal hypertension

1992 • 134 citations

The Role of Bile and Bile Acids in Bacterial Translocation in Obstructive Jaundice in Rats

1993 • 134 citations

A rodent model of cirrhosis, ascites, and bacterial peritonitis

1991 • 133 citations

Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors

1993 • 133 citations

Effects of prostaglandin inhibition on systemic and hepatic hemodynamics in patients with cirrhosis of the liver

1985 • 132 citations

Inhibition of adrenergic vasoconstriction by endothelial cell shear stress.

1988 • 131 citations

Effective plasma volume in cirrhosis with ascites. Evidence that a decreased value does not account for renal sodium retention, a spontaneous reduction in glomerular filtration rate (GFR), and a fall in GFR during drug-induced diuresis

1969 • 113 citations

Nω-Nitro-L-arginine Administration Corrects Peripheral Vasodilation and Systemic Capillary Hypotension and Ameliorates Plasma Volume Expansion and Sodium Retention in Portal Hypertensive Rats

1993 • 113 citations

Endothelial regulation of vascular tone

1992 • 94 citations

Role of prostacyclin in hemodynamic alterations in conscious rats with extrahepatic or intrahepatic portal hypertension

1993 • 89 citations

Temporal relationships between urinary salt retention and altered systemic hemodynamics in dogs with experimental cirrhosis.

1978 • 87 citations

Cardiovascular Complications of Liver Disease

2023 • 84 citations

Blood volume in patients with Laennec's cirrhosis of the liver as determined by radioactive chromium-tagged red cells

1956 • 81 citations

Impaired reactivity of the peripheral vasculature to pressor agents in alcoholic cirrhosis

1993 • 77 citations

Effects of nitric oxide and cyclooxygenase inhibition on splanchnic hemodynamics in portal hypertension

1993 • 74 citations

The Relationship Between Prostacyclin Activity and Pressure in the Portal Vein

1982 • 72 citations

Evidence for normal nitric oxide—mediated vasodilator tone in conscious rats with cirrhosis

1992 • 69 citations

Systemic and renal production of thromboxane A2 and prostacyclin in decompensated liver disease and hepatorenal syndrome

1991 • 63 citations

Renal sodium retention and ascites formation in dogs with experimental cirrhosis but without portal hypertension or increased splanchnic vascular capacity.

1978 • 62 citations

THE PLASMA VOLUME IN LAENNEC'S CIRRHOSIS OF THE LIVER

1946 • 60 citations

Inhaled nitric oxide: dose response and the effects of blood in the isolated rat lung

1993 • 56 citations

The biology of nitric oxide. 1. Physiological and clinical aspects

1993 • 47 citations

Dogs with experimental cirrhosis of the liver but without intrahepatic hypertension do not retain sodium or form ascites.

1983 • 47 citations

HEMODYNAMIC STUDIES IN PATIENTS WITH LAENNECʼS CIRRHOSIS

1957 • 45 citations

Complications in Obstructive Jaundice: Role of Endotoxins

1992 • 43 citations

A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat.

1990 • 41 citations

Effect of Local Inhibition of Nitric Oxide Synthesis on Forearm Blood Flow and Dorsal Hand Vein Size in Patients with Alcoholic Cirrhosis

1994 • 41 citations

Release of prostanoids into the portal and hepatic vein in patients with chronic liver disease

1986 • 40 citations

Nitric oxide inhibition varies with hemoglobin saturation

1993 • 36 citations

Evidence for role of prostacyclin as a systemic hormone in portal hypertension.

1991 • 27 citations

Endotoxin and the hyperdynamic circulation of portal vein—ligated rats

1990 • 24 citations

Portal Vein Prostacyclin Activity in Experimental Portal Hypertension in Rats

1981 • 24 citations

Resistance Artery Tone Is Influenced Independently by Pressure and by Flow

1990 • 24 citations

Vascular Myocyte-Derived Nitric Oxide Is an Autocrine That Limits Vasoconstriction

1993 • 23 citations

Sodium retention in dogs with experimental cirrhosis following removal of ascites by continuous peritoneovenous shunting.

1979 • 22 citations

Tone dependent nitric oxide production in ovine vessels in vitro

1993 • 18 citations

The role of prostacyclin in patients with portal hypertension

1985 • 15 citations

Late Effects of Portal Systemic Shunting Procedures on Cardiorespiratory Dynamics in Man

1972 • 14 citations

Vascular smooth muscle and nitric oxide

1993 • 13 citations

Nitric oxide synthase activity in portal hypertension

1993 • 12 citations

Effects of nitroglycerin on forearm haemodynamics in patients with cirrhosis

1988 • 10 citations

The effect of obstructive jaundice on systemic concentrations of bile acids, histamine and antibodies to the core region of endotoxin glycolipid

1993 • 2 citations

[Blood and plasma viscosity in liver cirrhosis (author's transl)].

1974 • 2 citations

Location of events

1993 • 1 citations