Further studies on the relationship of the stimulatory effects of phenobarbital and 3,4-benzpyrene on hepatic heme synthesis to their effects on hepatic microsomal drug oxidations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

The Induction in Vitro of the Synthesis of δ-Aminolevulinic Acid Synthetase in Chemical Porphyria: A Response to Certain Drugs, Sex Hormones, and Foreign Chemicals

1966 • 764 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems

1965 • 503 citations

Increase in Activity of δ-Aminolevulinic Acid Synthetase in Liver Mitochondria Induced by Feeding of 3, 5-Dicarbethoxy-1, 4-dihydrocollidine

1963 • 431 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

1963 • 413 citations

EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG‐METABOLIZING ENZYMES

1965 • 381 citations

δ-Aminolevulinic Acid Synthetase

1966 • 307 citations

Cytochrome P-450 of liver microsomes—One pigment or many

1968 • 224 citations

Effects of Phenobarbital on the Synthesis and Degradation of the Protein Components of Rat Liver Microsomal Membranes

1969 • 223 citations

Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.

1969 • 218 citations

The effect of carbohydrate feeding on the induction of δ-aminolevulinic acid synthetase

1964 • 208 citations

Importance of fundamental principles in drug evaluation

1968 • 196 citations

Puromycin Inhibition of Enzyme Induction by 3-Methylcholanthrene and Phenobarbital

1963 • 179 citations

Steroid Induction of Porphyrin Synthesis in Liver Cell Culture

1968 • 145 citations

Behavior of hepatic microsomal cytochromes after treatment of mice with drugs known to disturb porphyrin metabolism in liver

1968 • 132 citations

The influence of phenobarbital on the turnover of hepatic microsomal cytochrome b5 and cytochrome P-450 hemes in the rat

1970 • 129 citations

Induction of the Synthesis of δ-Amino-levulinic Acid Synthetase in Liver Parenchyma Cells in Culture by Chemicals That Induce Acute Porphyria

1963 • 118 citations

Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.

1969 • 111 citations

Enhanced formation of rapidly labeled bilirubin by phenobarbital: Hepatic microsomal cytochromes as a possible source

1966 • 105 citations

Effect of 3-amino-1,2,4-triazole on the stimulation of hepatic microsomal heme synthesis and induction of hepatic microsomal oxidases produced by phenobarbital.

1969 • 105 citations

FURTHER STUDIES ON THE INDUCTION OF THE DRUG-HYDROXYLATING ENZYME SYSTEM OF LIVER MICROSOMES

1965 • 96 citations

Mechanism of allylisopropylacetamide-induced increase of δ-aminolevulinate synthetase in liver mitochondria

1969 • 92 citations

A Sensitive Radiochemical Assay Method for δ-Aminolevulinic Acid Synthetase

1969 • 77 citations

Heme and methemoglobin: Naturally occurring repressors of microsomal cytochrome

1968 • 69 citations

HEPATIC PORPHYRIA AND DRUG-INDUCED OR CHEMICAL PORPHYRIA*

1965 • 63 citations

Microsomes and Drug Oxidations

1969 • 58 citations

The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene

1969 • 32 citations

On the Reduced Minus Oxidized Difference Spectrum of P-450 in Liver Microsomes

1967 • 25 citations