Monitoring secretion in real time: capacitance, amperometry and fluorescence compared

Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells.

1982 • 1,010 citations

Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells.

1991 • 876 citations

Optical Analysis of Synaptic Vesicle Recycling at the Frog Neuromuscular Junction

1992 • 766 citations

Calcium dependence of the rate of exocytosis in a synaptic terminal

1994 • 746 citations

Release of secretory products during transient vesicle fusion

1993 • 582 citations

Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals

1992 • 580 citations

Multiple calcium-dependent processes related to secretion in bovine chromaffin cells

1993 • 524 citations

The kinetics of synaptic vesicle recycling measured at single presynaptic boutons

1993 • 523 citations

Capacitance measurements reveal stepwise fusion events in degranulating mast cells

1984 • 506 citations

Imaging exocytosis and endocytosis

1996 • 451 citations

Dynamics of synaptic vesicle fusion and membrane retrieval in synaptic terminals

1994 • 449 citations

Measuring Serotonin Distribution in Live Cells with Three-Photon Excitation

1997 • 414 citations

Real-time measurement of transmitter release from single synaptic vesicles

1995 • 404 citations

Protein Kinase C Enhances Exocytosis from Chromaffin Cells by Increasing the Size of the Readily Releasable Pool of Secretory Granules

1996 • 395 citations

Kinetics of the secretory response in bovine chromaffin cells following flash photolysis of caged Ca2+

1994 • 343 citations

Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells

1995 • 337 citations

A Ca-Dependent Early Step in the Release of Catecholamines from Adrenal Chromaffin Cells

1993 • 312 citations

Evidence That Vesicles on the Synaptic Ribbon of Retinal Bipolar Neurons Can Be Rapidly Released

1996 • 297 citations

Synaptic vesicle dynamics in living cultured hippocampal neurons visualized with CY3-conjugated antibodies directed against the lumenal domain of synaptotagmin

1995 • 294 citations

Vesicle pool mobilization during action potential firing at hippocampal synapses

1995 • 289 citations

Modeling Buffered Ca2+ Diffusion Near the Membrane

1997 • 285 citations

Techniques for Membrane Capacitance Measurements

1995 • 284 citations

Rapid endocytosis coupled to exocytosis in adrenal chromaffin cells involves Ca2+, GTP, and dynamin but not clathrin.

1995 • 278 citations

Calcium-triggered exocytosis and endocytosis in an isolated presynaptic cell: Capacitance measurements in saccular hair cells

1994 • 255 citations

Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells

1994 • 254 citations

A cGMP-gated current can control exocytosis at cone synapses

1994 • 244 citations

The timing of synaptic vesicle endocytosis.

1996 • 238 citations

Nicotinic receptor-mediated catecholamine secretion from individual chromaffin cells. Chemical evidence for exocytosis.

1990 • 228 citations

Optical monitoring of transmitter release and synaptic vesicle recycling at the frog neuromuscular junction.

1993 • 214 citations

FM1-43 dye ultrastructural localization in and release from frog motor nerve terminals.

1996 • 210 citations

Rapid fluctuations in transmitter release from single vesicles in bovine adrenal chromaffin cells

1996 • 193 citations

Continuous Vesicle Cycling in the Synaptic Terminal of Retinal Bipolar Cells

1996 • 193 citations

Intermediates in synaptic vesicle recycling revealed by optical imaging of Drosophila neuromuscular junctions

1994 • 188 citations

Nerve Activity but Not Intracellular Calcium Determines the Time Course of Endocytosis at the Frog Neuromuscular Junction

1996 • 180 citations

A triggered mechanism retrieves membrane in seconds after Ca(2+)-stimulated exocytosis in single pituitary cells

1994 • 177 citations

Fast steps in exocytosis and endocytosis studied by capacitance measurements in endocrine cells

1996 • 159 citations

Direct measurement of exocytosis and calcium currents in single vertebrate nerve terminals

1990 • 158 citations

Mechanisms Determining the Time Course of Secretion in Neuroendocrine Cells

1996 • 149 citations

Rapid Exocytosis in Single Chromaffin Cells Recorded from Mouse Adrenal Slices

1997 • 147 citations

The exocytotic fusion pore of small granules has a conductance similar to an ion channel.

1995 • 133 citations

Electrochemical Detection of Secretion from Single Cells

1995 • 130 citations

Millisecond studies of secretion in single rat pituitary cells stimulated by flash photolysis of caged Ca2+.

1993 • 126 citations

Multiple innervation of tonic endplates revealed by activity-dependent uptake of fluorescent probes

1985 • 125 citations

Okadaic acid disrupts clusters of synaptic vesicles in frog motor nerve terminals

1994 • 114 citations

Calmodulin Is the Divalent Cation Receptor for Rapid Endocytosis, but Not Exocytosis, in Adrenal Chromaffin Cells

1996 • 113 citations

Mobility of Synaptic Vesicles in Nerve Endings Monitored by Recovery from Photobleaching of Synaptic Vesicle-Associated Fluorescence

1996 • 108 citations

Synaptic Vesicle Movements Monitored by Fluorescence Recovery after Photobleaching in Nerve Terminals Stained with FM1-43

1996 • 102 citations

Rapid exocytosis and endocytosis in nerve terminals of the rat posterior pituitary.

1996 • 102 citations

Amperometric detection of stimulus-induced quantal release of catecholamines from cultured superior cervical ganglion neurons.

1995 • 100 citations

Calcium dependence of large dense-cored vesicle exocytosis evoked by calcium influx in bovine adrenal chromaffin cells

1996 • 90 citations

Simultaneous capacitance and amperometric measurements of exocytosis: a comparison

1996 • 76 citations

Gradual and stepwise changes in the membrane capacitance of rat peritoneal mast cells.

1987 • 69 citations

Kinetics of stimulus-coupled secretion in dialyzed bovine chromaffin cells in response to trains of depolarizing pulses

1996 • 67 citations

Patterns of synaptic activity in neural networks recorded by light emission from synaptolucins

1997 • 51 citations

Purinergic receptor stimulation increases membrane trafficking in brown adipocytes.

1996 • 33 citations