Mechanisms by which hapten conjugates of pneumococcal polysaccharide interfere with the challenge of anti‐hapten memory cells

Colorimetric Method for Determination of Sugars and Related Substances

1956 • 48,885 citations

Plaque Formation in Agar by Single Antibody-Producing Cells

1963 • 2,385 citations

The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain

1959 • 2,294 citations

Methods in Immunology and Immunochemistry

1967 • 1,145 citations

Antitrinitrophenyl (TNP) Plaque Assay. Primary Response of Balb/c Mice to Soluble and Particulate Immunogen

1969 • 935 citations

Chemical Fixation of Enzymes to Cyanogen Halide Activated Polysaccharide Carriers

1971 • 547 citations

Evidence for the clonal abortion theory of B-lymphocyte tolerance.

1975 • 293 citations

ABSORPTION OF GUINEA PIG SERUM WITH AGAR

1970 • 284 citations

SUPPRESSION OF IDIOTYPIC SPECIFICITIES IN ADULT MICE BY ADMINISTRATION OF ANTIIDIOTYPIC ANTIBODY

1972 • 270 citations

Idiotype suppression. I. Influence of the dose and of the effector functions of anti‐idiotypic antibody on the production of an idiotype

1974 • 249 citations

SUPPRESSION OF IMMUNOGLOBULIN CLASS SYNTHESIS IN MICE

1972 • 240 citations

A Localized Haemolysis in Gel Method for the Detection of Cells Producing 7S Antibody: Detection of Cells producing 7S Antibodies by the Plaque Technique

1965 • 223 citations

Distribution of immunoglobulin on the surface of mouse lymphoid cells as determined by immunoferritin electron microscopy, Antibody‐induced, temperature‐dependent redistribution and its implications for membrane structure

1972 • 212 citations

AMINO ACID COMPOSITIONS OF HUMAN AND RABBIT γ-GLOBULINS AND OF THE FRAGMENTS PRODUCED BY REDUCTION

1963 • 192 citations

Studies on immunological paralysis

1971 • 182 citations

REGULATION OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE

1973 • 157 citations

CRITICAL ROLE OF DETERMINANT PRESENTATION IN THE INDUCTION OF SPECIFIC RESPONSES IN IMMUNO-COMPETENT LYMPHOCYTES

1973 • 155 citations

Lipopolysaccharide can substitute for helper cells in the antibody response in vitro

1972 • 143 citations

IMMUNOLOGICAL TOLERANCE IN BONE MARROW-DERIVED LYMPHOCYTES

1972 • 134 citations

CELLULAR REQUIREMENTS FOR THE PRIMARY IN VITRO ANTIBODY RESPONSE TO DNP-FICOLL

1974 • 134 citations

Inhibition of secondary anti‐hapten responses with the hapten conjugated to type 3 pneumococcal polysaccharide

1972 • 128 citations

EFFECTOR CELL BLOCKADE

1974 • 114 citations

THE SPECIFIC POLYSACCHARIDES OF TYPES I, II, AND III PNEUMOCOCCUS

1936 • 108 citations

ACTIVE SUPPRESSION OF IMMUNOGLOBULIN ALLOTYPE SYNTHESIS

1972 • 107 citations

PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN INDUCES IMMUNOGLOBULIN PRODUCTION IN NORMAL MOUSE SPLEEN CELLS

1973 • 102 citations

Cellular Site of Action of Various Adjuvants in Antibody Responses to Hapten-Carrier Conjugates

1973 • 94 citations

The Tolerant Cell: Direct Evidence for Receptor Blockade by Tolerogen

1974 • 93 citations

A buffered chromic chloride method of attaching antigens to red cells: Use in haemagglutination

1974 • 90 citations

Requirement for accessory cells in the antibody response to T cell‐independent antigens in vitro

1976 • 79 citations

Prevention of Murine Lupus Nephritis by Carrier-Dependent Induction of Immunologic Tolerance to Denatured DNA

1973 • 68 citations

The influence of epitope density on the immunological properties of hapten-protein conjugates

1974 • 67 citations

The Fate of Anti-Ig-Surface Ig Complexes on B Lymphocytes

1973 • 65 citations

Action of dextran sulfate as a direct and general B cell mitogen

1974 • 65 citations

Studies on immunological paralysis. II. The detection and significance of antibod-forming cells in the spleen during immunological paralysis with type 3 pneumococcal polysaccharide.

1969 • 61 citations

The Pneumococcal Polysaccharides

1964 • 52 citations

Failure of Lymphocytes to Reexpress Antigen Receptors after Brief Interaction with a Tolerogenic D-Amino Acid Copolymer

1974 • 43 citations

Studies on immunological paralysis. X. Cellular characteristics of the induction and loss of tolerance to levan (Polyfructose).

1972 • 42 citations

Induction of B cell tolerance to polysaccharides by exhaustive immunization and during immunosuppression with cyclophosphamide

1974 • 41 citations

Studies on immunological paralysis. 3. Recirculation and antibody-neutralizing activity of 14C-labelled type 3 pneumococcal polysaccharide in paralysed mice.

1970 • 40 citations

THE ANAMNESTIC ANTIBODY RESPONSE TO TYPE III SPECIFIC PNEUMOCOCCAL POLYSACCHARIDE

1969 • 40 citations

Clonal Expansion of Lipopolysaccharide-Stimulated B Lymphocytes

1974 • 39 citations

Induction of primary and inhibition of secondary antibody response to hapten by hapten conjugates of type III pneumococcal polysaccharide

1975 • 37 citations

Antibody-mediated suppression of the immune response in vitro. IV. The effect of antibody fragments.

1972 • 37 citations

Antigen recognition. IV. Discrimination by antigen-binding immunocompetent B cells between immunity and tolerance is determined by adherent cells.

1976 • 36 citations

The Immune Capacity of Lymphocytes after Cross-Linking of Surface Immunoglobulin Receptors by Antibody

1972 • 32 citations

Mechanisms of antibody formation

1975 • 30 citations

The immunological properties of haptens coupled to thymus‐independent carrier molecules. III. The role of the immunogenicity and mitogenicity of the carrier in the induction of primary IgM anti‐hapten responses

1975 • 29 citations

THE PRODUCTION OF ANTIPNEUMOCOCCIC SERUM

1917 • 28 citations

Antibody-Mediated Suppression of the Immune Response in vitro

1972 • 28 citations

B cell tolerance induced by polymeric antigens. II. Effects of tolerance on hapten‐binding lymphocyte levels in primary and secondaryantibody responses

1975 • 26 citations

Secondary IgG responses to type III pneumococcal polysaccharide. I. Kinetics and antigen requirements.

1975 • 26 citations

Studies on immunological paralysis VII. Rapid reversal of Felton’s paralysis as evidence for ‘tolerant’ cells

1972 • 24 citations

Studies on immunological paralysis. XI. A comparison of the tolerogenicity in vitro of levan and type 3 pneumococcal polysaccharide

1973 • 23 citations

Defective activation of b5 bearing lymphocytes in rabbits recovering from b5 allotype suppression

1974 • 19 citations

Secondary IgG Responses to Type III Pneumococcal Polysaccharide

1975 • 19 citations

Inhibition of murine plasmacytoma TEPC 15 by its specific antigen

1975 • 17 citations

IMMUNOCHEMISTRY OF THE PNEUMOCOCCAL TYPES II, V, AND VI III

1962 • 16 citations

Antigen-binding Small Lymphocytes in Delayed Hypersensitivity to Tuberculin

1971 • 16 citations

Reversible Blocking Effect of Anti-mouse Immunoglobulin Serum on the Induction of Immunity and Tolerance in vitro

1971 • 15 citations

Development of primary M, G, and A anti-TNP plaque-forming cell responses in vitro.

1973 • 14 citations

Immunological memory function of the T and B cell types: distribution over mouse spleen and lymph nodes

1975 • 14 citations

Prevention of Myeloma Growth in BALB/c Mice by Injection of Anti-Immunoglobulin Antisera

1974 • 13 citations

7S Class-Restricted Hapten-Specific Paralysis by Injection of Thymus-Independent Hapten-Carrier Conjugate

1975 • 10 citations

Development of Primary γM, γG, and γA Anti-TNP Plaque-Forming Cell Responses in Vitro

1973 • 8 citations

The in vitro induction of specific unresponsiveness against the 2,4,6-trinitrophenyl determinant

1975 • 5 citations

THREE CATEGORIES OF B CELL TOLERANCE INDUCED BY POLYSACCHARIDES: CHARACTERISTICS, INTERRELATIONSHIPS AND GENERAL IMPLICATIONS

1974 • 5 citations

Induction of an immune response through interaction of helper cells with an immune complex bound to the surface of B cells.

1975 • 4 citations

IS THERE A UNIFYING CONCEPT FOR DIVERSE MODELS OF TOLERANCE INDUCTION?

1974 • 3 citations

Promotion of secondary anti-DNP antibody production in mice by type III pneumococcal polysaccharide (SIII) and dinitrophenylated rabbit antibody to SIII.

1975 • 1 citations