Homo- and Heterotypic Fibrillin-1 and -2 Interactions Constitute the Basis for the Assembly of Microfibrils

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

1997 • 5,415 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

How to measure and predict the molar absorption coefficient of a protein

1995 • 3,771 citations

Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.

1986 • 1,129 citations

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes

1991 • 666 citations

Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein

2003 • 531 citations

Solution Structure of a Pair of Calcium-Binding Epidermal Growth Factor-like Domains: Implications for the Marfan Syndrome and Other Genetic Disorders

1996 • 437 citations

Immunohistologic Abnormalities of the Microfibrillar-Fiber System in the Marfan Syndrome

1990 • 393 citations

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices

1994 • 386 citations

Targetting of the gene encoding fibrillin–1 recapitulates the vascular aspect of Marfan syndrome

1997 • 385 citations

Partial sequence of a candidate gene for the Marfan syndrome

1991 • 370 citations

Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome

1993 • 356 citations

Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome

1993 • 312 citations

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

1995 • 307 citations

The molecular genetics of Marfan syndrome and related microfibrillopathies

2000 • 299 citations

Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils

1991 • 276 citations

Marfan syndrome: defective synthesis, secretion, and extracellular matrix formation of fibrillin by cultured dermal fibroblasts.

1992 • 267 citations

Fibrillin Binds Calcium and Is Coded by cDNAs That Reveal a Multidomain Structure and Alternatively Spliced Exons at the 5′ End

1993 • 259 citations

Fibrillin-1: Organization in Microfibrils and Structural Properties

1996 • 246 citations

Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.

1996 • 222 citations

Versican Interacts with Fibrillin-1 and Links Extracellular Microfibrils to Other Connective Tissue Networks

2002 • 212 citations

Fibrillin-1 and Fibulin-2 Interact and Are Colocalized in Some Tissues

1996 • 211 citations

Extraction of extendable beaded structures and their identification as fibrillin-containing extracellular matrix microfibrils.

1991 • 205 citations

The protein components of the 12-nanometer microfibrils of elastic and nonelastic tissues

1989 • 204 citations

Bovine Latent Transforming Growth Factor β1-Binding Protein 2: Molecular Cloning, Identification of Tissue Isoforms, and Immunolocalization to Elastin-Associated Microfibrils

1995 • 186 citations

Genetic disorders of the elastic fiber system

2000 • 176 citations

Interactions of Fibrillin-1 with Heparin/Heparan Sulfate, Implications for Microfibrillar Assembly

2001 • 163 citations

Further Characterization of Proteins Associated with Elastic Fiber Microfibrils Including the Molecular Cloning of MAGP-2 (MP25)

1996 • 151 citations

The Supramolecular Organization of Fibrillin-Rich Microfibrils

2001 • 150 citations

Prediction of the Coding Sequences of Unidentified Human Genes. XX. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro

2001 • 143 citations

Protein Interaction Studies of MAGP-1 with Tropoelastin and Fibrillin-1

2001 • 142 citations

Quantitative differences in biosynthesis and extracellular deposition of fibrillin in cultured fibroblasts distinguish five groups of Marfan syndrome patients and suggest distinct pathogenetic mechanisms.

1994 • 129 citations

Fibrillins Can Co-assemble in Fibrils, but Fibrillin Fibril Composition Displays Cell-specific Differences

2003 • 127 citations

Mutations in Calcium-binding Epidermal Growth Factor Modules Render Fibrillin-1 Susceptible to Proteolysis

2000 • 114 citations

Alignment of Fibrillin Molecules in Elastic Microfibrils Is Defined by Transglutaminase-Derived Cross-Links

1997 • 102 citations

Microfibril-associated glycoprotein-1 (MAGP-1) is specifically located on the beads of the beaded-filament structure for fibrillin-containing microfibrils as visualized by the rotary shadowing technique.

1996 • 98 citations

The extracellular portion of the human blood‐air barrier and its relation to tissue space

1961 • 88 citations

Initial Steps in Assembly of Microfibrils

2000 • 84 citations

Clustering ofFBN2 mutations in patients with congenital contractural arachnodactyly indicates an important role of the domains encoded by exons 24 through 34 during human development

1998 • 82 citations

Processing of the Fibrillin-1 Carboxyl-terminal Domain

1999 • 81 citations

Fibrillin-1 in Human Cartilage: Developmental Expression and Formation of Special Banded Fibers

1997 • 77 citations

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly

1999 • 69 citations

Evidence for furin-type activity-mediated C-terminal processing of profibrillin-1 and interference in the processing by certain mutations

1998 • 63 citations

Fibrillin assembly: dimer formation mediated by amino-terminal sequences

1999 • 55 citations

Abnormal morphology of fibrillin microfibrils in fibroblast cultures from patients with neonatal Marfan syndrome.

1995 • 35 citations

Atomic force microscopy and modeling of natural elastic fibrillin polymers

1998 • 22 citations