Initial Treatment of Hypertension

Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

1998 • 5,793 citations

The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure

1997 • 5,689 citations

A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure

1997 • 5,637 citations

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

2002 • 5,558 citations

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 5,471 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet

2001 • 5,241 citations

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

1998 • 4,813 citations

Blood pressure, stroke, and coronary heart disease

1990 • 4,424 citations

1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension

1999 • 3,718 citations

Impact of High-Normal Blood Pressure on the Risk of Cardiovascular Disease

2001 • 2,092 citations

Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials

2000 • 1,789 citations

Human blood pressure determination by sphygmomanometry.

1993 • 1,593 citations

Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study

1999 • 1,472 citations

Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial

1998 • 1,429 citations

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group

1991 • 1,361 citations

Trends in the Prevalence, Awareness, Treatment, and Control of Hypertension in the Adult US Population

1995 • 1,268 citations

Single-Drug Therapy for Hypertension in Men -- A Comparison of Six Antihypertensive Agents with Placebo

1993 • 1,210 citations

Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials

2000 • 1,181 citations

The Effect of Nisoldipine as Compared with Enalapril on Cardiovascular Outcomes in Patients with Non-Insulin-Dependent Diabetes and Hypertension

1998 • 1,166 citations

A Comparison of Outcomes with Angiotensin-Converting–Enzyme Inhibitors and Diuretics for Hypertension in the Elderly

2003 • 1,135 citations

Cardiovascular protection and blood pressure reduction: a meta-analysis

2001 • 963 citations

Health Outcomes Associated With Antihypertensive Therapies Used as First-Line Agents<subtitle>A Systematic Review and Meta-analysis</subtitle>

1997 • 887 citations

Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group

1993 • 841 citations

Effect of Reduced Dietary Sodium on Blood Pressure

1996 • 559 citations

Randomized trials of sodium reduction: an overview

1997 • 534 citations

Recommendations for the use of home (self) and ambulatory blood pressure monitoring

1996 • 489 citations

Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials

2000 • 402 citations

British Hypertension Society guidelines for hypertension management 1999: summary

1999 • 378 citations

Elevated systolic blood pressure as a cardiovascular risk factor

2000 • 356 citations

Low Urinary Sodium Is Associated With Greater Risk of Myocardial Infarction Among Treated Hypertensive Men

1995 • 304 citations

Effects of Reduced Sodium Intake on Hypertension Control in Older Individuals

2001 • 277 citations

Management of raised blood pressure in New Zealand: a discussion document.

1993 • 270 citations

A Comparison of the Efficacy and Safety of a β-Blocker, a Calcium Channel Blocker, and a Converting Enzyme Inhibitor in Hypertensive Blacks

1990 • 263 citations

Relationships of Quality-of-Life Measures to Long-term Lifestyle and Drug Treatment in the Treatment of Mild Hypertension Study

1997 • 206 citations

Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis

1997 • 172 citations

Blood pressure and high blood pressure. Aspects of risk.

1991 • 156 citations

Effect of reduced dietary sodium on blood pressure: a meta-analysis of randomized controlled trials

1996 • 125 citations

The Effectiveness of Long-Term Treatment of Malignant Hypertension

1958 • 113 citations

Low-dose drug combination therapy: An alternative first-line approach to hypertension treatment

1995 • 76 citations

Potency of vascular risk factors as the basis for antihypertensive therapy

1992 • 53 citations

Does drug treatment improve survival? Reconciling the trials in mild-to-moderate hypertension

1995 • 51 citations

Relationships of quality-of-life measures to long-term lifestyle and drug treatment in the Treatment of Mild Hypertension Study

1997 • 42 citations

A comparison of the efficacy and safety of a beta-blocker, a calcium channel blocker, and a converting enzyme inhibitor in hypertensive blacks

1990 • 33 citations

Dietary sodium reduction: is there cause for concern?

1997 • 31 citations

Should calcium antagonists be first-line agents in the treatment of cardiovascular disease? The public health perspective

1996 • 9 citations

Low Dose Combination Therapy vs. High Dose Monotherapy in the Management of Hypertension.

1999 • 8 citations

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