Human neuroblastoma cell lines as models for the in vitro study of neoplastic and neuronal cell differentiation.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN

1925 • 1,630 citations

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

1973 • 1,284 citations

Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

1980 • 1,094 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

The Migration and Differentiation of Neural Crest Cells

1970 • 814 citations

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

1981 • 808 citations

Role of retinoids in differentiation and carcinogenesis.

1983 • 780 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

The Calcium Messenger System

1986 • 669 citations

Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells

1975 • 663 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

1982 • 630 citations

Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide.

1979 • 602 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation

1984 • 558 citations

Coordinate Morphological and Biochemical Interconversion of Human Neuroblastoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1983 • 544 citations

Structure and activation of the human N-ras gene

1983 • 538 citations

Morphological Transformation of Chinese Hamster Cells by Dibutyryl Adenosine Cyclic 3′:5′-Monophosphate and Testosterone

1971 • 529 citations

Definition of a continuous human cell line derived from neuroblastoma.

1970 • 480 citations

Expression and amplification of the N-myc gene in primary retinoblastoma

1984 • 451 citations

Restoration of Several Morphological Characteristics of Normal Fibroblasts in Sarcoma Cells Treated with Adenosine-3′:5′-Cyclic Monophosphate and Its Derivatives

1971 • 440 citations

Cytogenetic features of human neuroblastomas and cell lines.

1981 • 386 citations

Retinoic Acid-Induced Growth Inhibition and Morphologic Differentiation of Human Neuroblastoma Cells In Vitro<xref ref-type="fn" rid="fn2">2</xref>

1982 • 384 citations

Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL‐60) by compounds which induce differentiation of murine leukemia cells

1980 • 350 citations

Voltage-gated potassium channels are required for human T lymphocyte activation.

1984 • 337 citations

DIFFERENTIATION OF NEUROBLASTOMA CELLS IN CULTURE

1975 • 334 citations

Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines

1983 • 319 citations

The Transformation of a Malignant Paravertebral Sympathicoblastoma into a Benign Ganglioneuroma.

1927 • 300 citations

Human small-cell lung cancers show amplification and expression of the N-myc gene.

1986 • 293 citations

Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.

1983 • 290 citations

Role of cyclic nucleotides in cell growth and differentiation

1976 • 290 citations

Properties of two types of calcium channels in clonal pituitary cells.

1986 • 280 citations

Post-transcriptional control of myc and p53 expression during differentiation of the embryonal carcinoma cell line F9

1985 • 274 citations

Phenotypic changes of human neuroblastoma cells in culture induced by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate

1981 • 255 citations

Effects of sodium butyrate and dimethylsulfoxide on biochemical properties of human colon cancer cells

1980 • 237 citations

Evidence for RNA synthesis-dependent and -independent pathways in stimulation of neurite outgrowth by nerve growth factor

1978 • 224 citations

Different Types of Calcium Channels

1986 • 204 citations

Consistent N-myc copy number in simultaneous or consecutive neuroblastoma samples from sixty individual patients.

1987 • 190 citations

Retinoids and cell differentiation

1986 • 187 citations

Priming of human myeloid leukemic cell lines HL-60 and U-937 with retinoic acid for differentiation effects of cyclic adenosine 3':5'-monophosphate-inducing agents and a T-lymphocyte-derived differentiation factor.

1982 • 181 citations

Initial Urinary Catecholamine Metabolite Concentrations and Prognosis in Neuroblastoma

1978 • 178 citations

Oncogenes, ions, and phospholipids

1985 • 171 citations

Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines

1982 • 168 citations

Definition of a Thy-1 determinant on human neuroblastoma, glioma, sarcoma, and teratoma cells with a monoclonal antibody.

1982 • 167 citations

Spontaneous regression of neuroblastoma.

1976 • 165 citations

Differentiation of human neuroblastoma recapitulates neural crest development. Study of morphology, neurotransmitter enzymes, and extracellular matrix proteins.

1987 • 161 citations

The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC12 cells.

1986 • 161 citations

Observations on the histopathology of neuroblastomas

1968 • 161 citations

Ionic responses and growth stimulation induced by nerve growth factor and epidermal growth factor in rat pheochromocytoma (PC12) cells.

1983 • 150 citations

myc oncogenes: activation and amplification

1987 • 147 citations

Protein Kinases: Aspects of Their Regulation and Diversity

1973 • 129 citations

Chemically induced murine erythroleukemic differentiation

1980 • 128 citations

Identification and Characterization of the Protein Encoded by the Human N- myc Oncogene

1986 • 128 citations

Histologic patterns of neuroblastoma related to prognosis and clinical staging

1974 • 124 citations

Neoplastic transformation by the human gene N-myc.

1987 • 124 citations

A human clonal cell line model of differentiating neurons

1979 • 115 citations

Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro.

1985 • 110 citations

Specific high-affinity binding and biologic action of retinoic acid in human neuroblastoma cell lines.

1983 • 107 citations

Polar solvents: a novel class of antineoplastic agents.

1984 • 105 citations

An early decrease in phosphatidylinositol turnover occurs on induction of friend cell differentiation and precedes the decrease in c-myc expression

1985 • 105 citations

Expression of neurotransmitter receptors and myc protooncogenes in subclones of a human neuroblastoma cell line.

1987 • 101 citations

New benzoic acid derivatives with retinoid activity: lack of direct correlation between biological activity and binding to cellular retinoic acid binding protein.

1987 • 98 citations

Effect of retinoic acid treatment of F9 embryonal carcinoma cells on the activity and distribution of cyclic AMP-dependent protein kinase.

1982 • 97 citations

Neuroblastoma: Clinical Perspectives, Monoclonal Antibodies, and Retinoic Acid

1982 • 96 citations

Effect of retinoic acid on nerve growth factor receptors

1987 • 90 citations

Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.

1988 • 89 citations

Decreased c-myc expression is an early event in retinoic acid-induced differentiation of F9 teratocarcinoma cells.

1986 • 89 citations

Nerve growth factor increases the number of functional Na channels and induces TTX-resistant Na channels in PC12 pheochromocytoma cells

1987 • 88 citations

Characterization of cytosolic calcium-activated phospholipid-dependent protein kinase activity in embryonal carcinoma cells. Effect of retinoc acid-induced differentiation of F9 cells to parietal endoderm.

1983 • 86 citations

Retinoic acid increases cyclic AMP-dependent protein kinase activity in murine melanoma cells.

1980 • 85 citations

Effects of sodium butyrate on synthesis of human chorionic gonadotrophin in trophoblastic and non-trophoblastic tumours

1977 • 82 citations

Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore.

1977 • 75 citations

Expression of N-myc and c-src during the development of fetal human brain.

1987 • 71 citations

Development of a neural phenotype in differentiating ganglion cell‐derived human neuroblastoma cells

1986 • 69 citations

Mechanisms of control for cAMP-dependent protein kinase from skeletal muscle.

1975 • 67 citations

Selection and characterization of F9 teratocarcinoma stem cell mutants with altered responses to retinoic acid.

1984 • 66 citations

X-ray-induced Morphological Differentiation of Mouse Neuroblastoma Cells in vitro

1971 • 66 citations

Voltage-gated Ca2+ channel in mouse myeloma cells.

1983 • 64 citations

The myc Oncogene: Its Role in Transformation and Differentiation

1986 • 64 citations

Hexamethylene bisacetamide induces morphologic changes and increased synthesis of procollagen in cell line from glioblastoma multiforme.

1977 • 61 citations

Chemically induced bidirectional differentiation of embryonal carcinoma cells in vitro.

1979 • 60 citations

B cell activation. VI. Effects of exogenous diglyceride and modulators of phospholipid metabolism suggest a central role for diacylglycerol generation in transmembrane signaling by mIg.

1985 • 58 citations

Retinoic acid treatment of human neuroblastoma cells is associated with decreased N-myc expression

1985 • 57 citations

Potassium channels in human NK cells are involved in discrete stages of the killing process.

1986 • 55 citations

Retinoic Acid-Induced Differentiation of Human Neuroblastoma: A Cell Variant System Showing Two Distinct Responses

1986 • 55 citations

Correlation between the induction of leukemic cell differentiation by various retinoids and modulation of protein kinases.

1986 • 53 citations

Retinoic acid fails to induce differentiation in human teratocarcinoma cell lines that express high levels of a cellular receptor protein

1983 • 51 citations

Differentiation-defective mutants of mouse embryonal carcinoma cells: Response to hexamethylenebisacetamide and retinoic acid

1983 • 48 citations

Characteristics of a new human neuroblastoma cell line which differentiates in response to cyclic adenosine 3':5'-monophosphate.

1984 • 47 citations

The role of cAMP in regulating tumour cell growth.

1986 • 46 citations

Lack of intracellular retinoid-binding proteins in a retinol-sensitive cell line

1982 • 45 citations

Effects of Butyrate, Retinol, and Retinoic Acid on Human Y-79 Retinoblastoma Cells Growing in Monolayer Cultures

1984 • 43 citations

Dibutyryl cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation

1986 • 43 citations

Phenotypic differentiation of aphidicolin-selected human neuroblastoma cultures after long-term exposure to nerve growth factor

1987 • 43 citations

Neuroblastoma: The Case for Screening Infants in North America

1987 • 41 citations

Cellular Retinol- and Retinoic Acid-Binding Proteins

1983 • 40 citations

Retinoic acid inhibits Ca²⁺ currents and cell proliferation in a B‐lymphocyte cell line

1988 • 39 citations

Extracellular Calcium‐Induced Neuroblastoma Cell Differentiation: Involvement of Phosphatidylinositol Turnover

1986 • 38 citations

The in vitro characterization of the inhibition of mouse brain protein kinase-C by retinoids and their receptors

1986 • 38 citations

Membrane properties of a human neuroblastoma II: Effects of differentiation

1981 • 36 citations

Neuroblastoma

1985 • 36 citations

Rapid transcriptional down-regulation of c-myc expression during cyclic adenosine monophosphate-promoted differentiation of leukemic cells.

1987 • 35 citations

Calcium‐activated, phospholipid‐dependent protein kinase activity and protein phosphorylation in HL60 cells induced to differentiate by retinoic acid

1985 • 34 citations

Modulation of Mr 53,000 protein with induction of differentiation of human neuroblastoma cells.

1988 • 33 citations

In vitro and in vivo growth characteristics of two different cell populations in an established line of human neuroblastoma.

1983 • 30 citations

N‐myc and c‐src genes are differentially regulated in PCC7 embryonal carcinoma cells undergoing neuronal differentiation

1986 • 29 citations

Properties of human neuroblastoma cells following induction by retinoic acid.

1985 • 28 citations

Prolonged infusion of hexamethylene bisacetamide: a phase I and pharmacological study.

1987 • 28 citations

Retinoic acid blocks potassium channels in human lymphocytes

1986 • 27 citations

Neoplastic Transformation by the Human Gene N-myc

1987 • 27 citations

Retinoid Effect on Calcium, Phospholipid-Dependent Protein Kinase from Mouse Skin

1986 • 27 citations

Homogeneously staining regions in direct preparations from human neuroblastomas.

1982 • 25 citations

Characterization of the Na+/H+ exchanger during maturation of HL-60 cells induced by dimethyl sulfoxide.

1987 • 23 citations

Intensive Kombinationschemotherapie und β-Interferon zur Behandlung von Kindern mit metastasiertem Neuroblastom: Studie GPO-NB 79/82

1984 • 23 citations

Role of intracellular calcium ion in human promyelocytic leukemia HL-60 cell differentiation.

1986 • 22 citations

The administration of the nerve growth factor to children with widespread neuroblastoma

1970 • 21 citations

Nerve growth factor and cyclic AMP: Opposite effects on neuroblastoma‐substrate adhesion

1982 • 20 citations

Modulation in proportions of H1 histone subfractions by differential changes in synthesis and turnover during butyrate treatment of neuroblastoma cells

1985 • 20 citations

Inhibition of dimethylsulfoxide-induced differentiation in friend erythroleukemic cells by diacylglycerols and phospholipase C

1984 • 20 citations

The in vivo inhibition of mouse brain protein kinase-C by retinoic acid

1986 • 19 citations

NGF effects on human neuroblastoma lines: a model system.

1982 • 18 citations

Identification and quantitation of intracellular retinol and retinoic acid binding proteins in cultured cells

1984 • 18 citations

Neurite formation and membrane changes of mouse neuroblastoma cells induced by valinomycin

1978 • 16 citations

Action of retinoic acid on the diacylglycerol-induced ornithine decarboxylase activity, reduction in EGF binding and protein kinase C activation in rat tracheal epithelial 2C5 cells

1986 • 16 citations

The effect of nerve growth factor on the development of sodium channels in PC12 cells

1986 • 14 citations

Saturation analysis of cellular retinoid binding proteins: application to retinoic acid resistant human neuroblastoma cells and to human tumors

1987 • 14 citations

Intra-aortic prostaglandin E1 infusion in maturation of neuroblastoma

1982 • 10 citations

Investigational chemotherapy of neuroblastoma.

1979 • 10 citations

Elevation of a potassium current in differentiating human leukemic (HL‐60) cells

1987 • 9 citations

Relationship of the decreases in protein synthesis and intracellular Na+ during friend murine erythroleukemic cell differentiation.

1986 • 8 citations

12-O-tetradecanoyl-phorbol-13-acetate-induced differentiation of human neuroblastoma cells is not accompanied by an increase in the intracellular concentration of cyclic AMP

1985 • 6 citations

Dimethyl sulfoxide-induced differentiation does not alter tumorigenicity of neuroblastoma cells

1985 • 4 citations

Cellular Retinol and Retinoic Acid-Binding Proteins

2015 • 3 citations

Neuroblastoma: Maturation and Differentiation

2020 • 2 citations