Macromolecular Crowding as a Cell VolumeSensor

Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences

1993 • 1,474 citations

Estimation of macromolecule concentrations and excluded volume effects for the cytoplasm of Escherichia coli

1991 • 1,253 citations

The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences

1983 • 503 citations

Osmotic stress, crowding, preferential hydration, and binding: A comparison of perspectives

2000 • 475 citations

Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells.

1987 • 395 citations

[7] Molecular crowding: Analysis of effects of high concentrations of inert cosolutes on biochemical equilibria and rates in terms of volume exclusion

1998 • 310 citations

Determinants of the translational mobility of a small solute in cell cytoplasm.

1993 • 295 citations

Biophysical compensation mechanisms buffering E. coli protein–nucleic acid interactions against changing environments

1998 • 224 citations

In defense of cell volume?

1993 • 194 citations

Confinement as a determinant of macromolecular structure and reactivity

1992 • 192 citations

Macromolecular crowding increases binding of DNA polymerase to DNA: an adaptive effect.

1987 • 178 citations

Macromolecular crowding and confinement in cells exposed to hypertonicity

1994 • 152 citations

In disperse solution, “osmotic stress” is a restricted case of preferential interactions

1998 • 113 citations

Tracer diffusion in F-actin and Ficoll mixtures. Toward a model for cytoplasm

1990 • 83 citations

Cytosolic protein concentration is the primary volume signal for swelling-induced [K-Cl] cotransport in dog red cells.

1992 • 82 citations

Cytosolic protein concentration is the primary volume signal in dog red cells.

1991 • 64 citations

Role of concentration and size of intracellular macromolecules in cell volume regulation

1997 • 26 citations