4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

1994 • 503 citations

P450 enzymes of estrogen metabolism

1993 • 395 citations

Carcinogenicity of catechol estrogens in Syrian hamsters

1986 • 360 citations

Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis.

1990 • 314 citations

Free radical generation by redox cycling of estrogens

1990 • 293 citations

Estrogen Metabolism and Excretion in Oriental and Caucasian Women

1994 • 255 citations

Characterization of Human Microsomal Cytochrome P-450 Enzymes

1989 • 244 citations

17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: A comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA

1992 • 242 citations

Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents.

1990 • 240 citations

Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression.

1994 • 209 citations

NADPH-cytochrome P-450 reductase from rat liver: purification by affinity chromatography and characterization

1977 • 205 citations

The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase

1994 • 196 citations

Cytochrome P-450-mediated redox cycling of estrogens.

1986 • 144 citations

Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes

1992 • 130 citations

Mechanism of anterior pituitary tumor induction by estrogen

1956 • 117 citations

Multiple functions of aromatase and the active site structure; aromatase is the placental estrogen 2-hydroxylase

1993 • 104 citations

Diet and urinary estrogen profile in premenopausal omnivorous and vegetarian women and in premenopausal women with breast cancer

1989 • 93 citations

Estrogen-induced tumors of the kidney. III. Growth characteristics in the Syrian hamster.

1959 • 91 citations

Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: a potential pathway of metabolic activation of estrogens.

1992 • 64 citations

Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells

1991 • 64 citations

Catechol estrogen formation in the mouse uterus and its role in implantation

1990 • 53 citations

Catechol Estrogen Formation by Brain Tissue: Characterization of a Direct Product Isolation Assay for Estrogen-2- and 4-Hydroxylase Activity and Its Application to Studies of 2- and 4-Hydroxyestradiol Formation by Rabbit Hypothalamus*

1981 • 50 citations

Monooxygenase Mediating Catecholestrogen Formation by Rot Anterior Pituitary is an Estrogen-4-Hydroxylose

1989 • 48 citations

In vitro potency and selectivity of the non-steroidal androgen aromatase inhibitor CGS 16949A compared to steroidal inhibitors in the brain

1992 • 38 citations

Mouse endometrium stromal cells express a polycyclic aromatic hydrocarbon-inducible cytochrome P450 that closely resembles the novel P450 in mouse embryo fibroblasts (P450EF)

1993 • 34 citations

Identification of Microsomal, Organic Hydroperoxide-Dependent Catechol Estrogen Formation: Comparison with NADPH-Dependent Mechanism

1988 • 26 citations

Potent inhibitory effects of suicide inhibitors of P450 isozyines on 7, 12-dimethylbenzℵaℵanthracene and benzoℵaℵpyrene initiated skin tumors

1991 • 14 citations