Subthalamic GAD Gene Therapy in a Parkinson's Disease Rat Model

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Deep-Brain Stimulation of the Subthalamic Nucleus or the Pars Interna of the Globus Pallidus in Parkinson's Disease

2001 • 1,472 citations

Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation

1995 • 1,340 citations

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1994 • 1,032 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease

1998 • 682 citations

Practice parameter: Thymectomy for autoimmune myasthenia gravis (an evidence-based review) [RETIRED]

2000 • 578 citations

Woodchuck Hepatitis Virus Contains a Tripartite Posttranscriptional Regulatory Element

1998 • 354 citations

Hippocampal GABA transporter function in temporal-lobe epilepsy

1995 • 333 citations

Neurons of the subthalamic nucleus in primates display glutamate but not GABA immunoreactivity

1988 • 326 citations

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

2000 • 326 citations

Basal expression and induction of glutamate decarboxylase GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus

1996 • 244 citations

Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies

1996 • 235 citations

Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA

1980 • 215 citations

Dorsal subthalamotomy for Parkinson's disease

2001 • 207 citations

Lidocaine and muscimol microinjections in subthalamic nucleus reverse parkinsonian symptoms

2001 • 193 citations

Hippocampal granule cells express glutamic acid decar☐ylase-67 after limbic seizures in the rat

1995 • 176 citations

Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy

1999 • 175 citations

Dose and Promoter Effects of Adeno-Associated Viral Vector for Green Fluorescent Protein Expression in the Rat Brain

2002 • 157 citations

Pathophysiologic basis of surgery for Parkinson's disease.

2000 • 126 citations

Terminals of subthalamonigral fibres are enriched with glutamate-like immunoreactivity: An electron microscopic, immunogold analysis in the cat

1993 • 123 citations

Immunological Aspects of Recombinant Adeno-Associated Virus Delivery to the Mammalian Brain

2002 • 115 citations

Antiparkinsonian and Behavioral Effects of Inactivation of the Substantia Nigra Pars Reticulata in Hemiparkinsonian Primates

2001 • 91 citations

Metabolic changes following subthalamotomy for advanced Parkinson's disease

2001 • 86 citations

Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat

1999 • 76 citations

Ablation of the subthalamic nucleus supports the survival of nigral dopaminergic neurons after nigrostriatal lesions induced by the mitochondrial toxin 3-nitropropionic acid

1999 • 75 citations

Subthalamic Nucleus Lesions Are Neuroprotective against Terminal 6-OHDA-Induced Striatal Lesions and Restore Postural Balancing Reactions

2001 • 60 citations

Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons.

1996 • 57 citations

Insulin Resistance and Insulin-Like Growth Factors in Children with Intrauterine Growth Retardation

2001 • 53 citations