Type 2 diabetes: new genes, new understanding

MicroRNAs

2004 • 33,206 citations

A haplotype map of the human genome

2005 • 5,856 citations

Global and societal implications of the diabetes epidemic

2001 • 5,825 citations

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

2007 • 4,239 citations

A genome-wide association study identifies novel risk loci for type 2 diabetes

2007 • 2,957 citations

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

2008 • 2,860 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

2007 • 2,820 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

2007 • 2,762 citations

A new multipoint method for genome-wide association studies by imputation of genotypes

2007 • 2,593 citations

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

2008 • 2,577 citations

Type 2 diabetes: principles of pathogenesis and therapy

2005 • 2,509 citations

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

2006 • 2,206 citations

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

2007 • 2,187 citations

A pancreatic islet-specific microRNA regulates insulin secretion

2004 • 2,054 citations

Genomewide Association Analysis of Coronary Artery Disease

2007 • 2,027 citations

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

2006 • 2,006 citations

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

2008 • 1,838 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

Large recurrent microdeletions associated with schizophrenia

2008 • 1,752 citations

A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

2007 • 1,588 citations

A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

2007 • 1,532 citations

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

1999 • 1,350 citations

Population genomics of human gene expression

2007 • 1,146 citations

Activating Mutations in the Gene Encoding the ATP-Sensitive Potassium-Channel Subunit Kir6.2 and Permanent Neonatal Diabetes

2004 • 1,118 citations

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

2007 • 1,092 citations

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

2007 • 1,060 citations

MicroRNA-143 Regulates Adipocyte Differentiation

2004 • 1,007 citations

p16INK4a induces an age-dependent decline in islet regenerative potential

2006 • 964 citations

The common biology of cancer and ageing

2007 • 949 citations

Multiple loci identified in a genome-wide association study of prostate cancer

2008 • 904 citations

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

2007 • 801 citations

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

2008 • 746 citations

Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic β-Cell KATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes

2003 • 745 citations

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

2008 • 728 citations

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

2007 • 726 citations

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

2008 • 702 citations

Copy-number variation and association studies of human disease

2007 • 623 citations

Genome–wide association studies provide new insights into type 2 diabetes aetiology

2007 • 580 citations

A Common Allele on Chromosome 9 Associated With Coronary Heart Disease

2007 • 531 citations

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

2007 • 525 citations

Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p

2007 • 507 citations

What makes a good genetic association study?

2005 • 476 citations

Identification and Cloning of a β-Cell–Specific Zinc Transporter, ZnT-8, Localized Into Insulin Secretory Granules

2004 • 457 citations

Evaluating coverage of genome-wide association studies

2006 • 417 citations

Highly parallel genomic assays

2006 • 388 citations

Common variants in WFS1 confer risk of type 2 diabetes

2007 • 374 citations

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

2008 • 352 citations

MicroRNA-9 Controls the Expression of Granuphilin/Slp4 and the Secretory Response of Insulin-producing Cells

2006 • 342 citations

Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk

2008 • 291 citations

Evaluating and improving power in whole-genome association studies using fixed marker sets

2006 • 288 citations

Association ofCDKAL1, IGF2BP2, CDKN2A/B, HHEX,SLC30A8,andKCNJ11With Susceptibility to Type 2 Diabetes in a Japanese Population

2007 • 280 citations

Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTOvariants confer a significant risk

2008 • 278 citations

Hexhomeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

2004 • 257 citations

Studies of Association of Variants Near the HHEX, CDKN2A/B, and IGF2BP2 Genes With Type 2 Diabetes and Impaired Insulin Release in 10,705 Danish Subjects

2007 • 256 citations

Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

2006 • 253 citations

Common Variants of the Novel Type 2 Diabetes GenesCDKAL1andHHEX/IDEAre Associated With Decreased Pancreatic β-Cell Function

2007 • 246 citations

Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population

2008 • 239 citations

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

2007 • 204 citations

Type 2 Diabetes Whole-Genome Association Study in Four Populations: The DiaGen Consortium

2007 • 198 citations

Localization of a Susceptibility Gene for Type 2 Diabetes to Chromosome 5q34–q35.2

2003 • 197 citations

Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish

2007 • 174 citations

MicroRNAs in Skeletal and Cardiac Muscle Development

2007 • 165 citations

Association Testing of Novel Type 2 Diabetes Risk Alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 Loci With Insulin Release, Insulin Sensitivity, and Obesity in a Population-Based Sample of 4,516 Glucose-Tolerant Middle-Aged Danes

2008 • 153 citations

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

2000 • 153 citations

Genetic Prediction of Future Type 2 Diabetes

2005 • 149 citations

Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-Wide Association Studies

2007 • 133 citations

Growing evidence for diabetes susceptibility genes from genome scan data

2003 • 123 citations

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

2007 • 112 citations

An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets

2005 • 110 citations

Distinct Roles of HNF1 Β , HNF1 α , and HNF4 α in Regulating Pancreas Development, Β -Cell Function and Growth

2007 • 107 citations

A Search for Variants Associated With Young-Onset Type 2 Diabetes in American Indians in a 100K Genotyping Array

2007 • 99 citations

A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham Heart Study

2007 • 97 citations

Candidate Genes for Type 2 Diabetes

2004 • 95 citations

Wolfram/DIDMOAD syndrome, a heterogenic and molecularly complex neurodegenerative disease.

2006 • 43 citations

Significant change in insulin production, glucose tolerance and ER stress signaling in transgenic mice coexpressing insulin-siRNA and human IDE

2007 • 18 citations

Deleted Work

1955 • 0 citations