Clinical Pharmacokinetics of Pethidine

Kinetics of acetaminophen absorption and gastric emptying in man

1978 • 369 citations

Sequential Changes of Plasma Proteins after Surgical Trauma

1972 • 358 citations

Accumulation of Normeperidine, an Active Metabolite of Meperidine, in Patients with Renal Failure or Cancer

1977 • 354 citations

NARCOTIC ANALGESICS AND DELAYED GASTRIC EMPTYING DURING LABOUR

1975 • 284 citations

Plasma protein binding of basic drugs

1977 • 228 citations

Multiple intramuscular injections: A major source of variability in analgesic response to meperidine

1980 • 220 citations

Relationship Between Blood Meperidine Concentrations and Analgesic Response

1980 • 207 citations

Meperidine kinetics in man; Intravenous injection in surgical patients and volunteers

1975 • 201 citations

Clinical Pharmacokinetics Pethidine

1978 • 174 citations

The effect of cirrhosis on the disposition and elimination of meperidine in man

1974 • 163 citations

Plasma protein binding of basic drugs. I. Selective displacement from alpha 1-acid glycoprotein by tris(2-butoxyethyl) phosphate.

1977 • 162 citations

Enhanced Bioavailability and Decreased Clearance of Analgesics in Patients with Cirrhosis

1979 • 133 citations

Patient-controlled Analgesic Therapy, Part II

1982 • 124 citations

Effects of meperidine on the newborn infant

1964 • 117 citations

Alpha1-acid glycoprotein concentration and protein binding in trauma

1982 • 106 citations

The effect of N-demethylation on certain pharmacologic actions of morphine, codeine, and meperidine in the mouse.

1954 • 98 citations

Antagonism of the convulsant effects of heroin, d-propoxyphene, meperidine, normeperidine and thebaine by naloxone in mice.

1975 • 98 citations

The physiological disposition and fate of meperidine (demerol) in man and a method for its estimation in plasma.

1955 • 96 citations

A Pharmacokinetic Approach to Postoperative Pain: Continuous Infusion of Pethidine

1979 • 86 citations

The Clinical Pharmacology of Meperidine—Comparison of Routes of Administration

1976 • 74 citations

Neonatal depression after obstetrical analgesia with pethidine. the role of the injection‐delivery time interval and of the plasma concentrations of pethidine and norpethidine

1981 • 72 citations

Meperidine and normeperidine levels following meperidine administration during labor

1979 • 72 citations

Metabolites of meperidine related to fetal depression

1973 • 72 citations

Effect of Acute Viral Hepatitis in Man on the Disposition and Elimination of Meperidine

1975 • 65 citations

Double-blind comparison of the neurobehaviour of neonates following the administration of different doses of meperidine to the mother

1978 • 60 citations

THE PLACENTAL TRANSMISSION OF PETHIDINE

1965 • 59 citations

PETHIDINE REVISITED: PLASMA CONCENTRATIONS AND EFFECTS AFTER INTRAMUSCULAR INJECTION

1975 • 58 citations

Effect of phenytoin on meperidine clearance and normeperidine formation

1981 • 54 citations

Drug Interaction: Meperidine and Chlorpromazine, a Toxic Combination

1981 • 54 citations

Meperidine binding in maternal and fetal plasma

1981 • 52 citations

Placental transfer of pethidine and norpethidine and their pharmacokinetics in the newborn

1980 • 51 citations

Meperidine and normeperidine levels following meperidine administration during labor

1979 • 51 citations

Presystemic metabolism of meperidine to normeperidine in normal and cirrhotic subjects

1981 • 49 citations

Systemic availability of orally administered meperidine

1976 • 44 citations

A POTENTIALLY TOXIC DRUG INTERACTION BETWEEN PETHIDINE (MEPERIDINE) AND PHENOBARBITONE

1977 • 43 citations

Biotransformation products of meperidine excreted in the urine of man.

1956 • 42 citations

THE EXCRETION OF PETHIDINE AND ITS DERIVATIVES

1963 • 41 citations

Meperidine disposition in man: Influence of urinary pH and route of administration

1981 • 41 citations

Displacement of lidocaine from serum? 1-acid glycoprotein binding sites by basic drugs

1983 • 37 citations

Patient-controlled Analgesic Therapy, Part I

1982 • 37 citations

Enhanced Bioavailability of Pethidine and Pentazocine in Patients with Cirrhosis of the Liver*

1980 • 36 citations

Meperidine disposition in mother, neonate, and nonpregnant females

1980 • 34 citations

Metabolites of meperidine in the fetal and maternal serum

1976 • 29 citations

Pharmacokinetics and analgesic effect of pethidine (meperidine) and its metabolites in the rat.

1979 • 29 citations

Analysis of the inhibition of pethidine N‐demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man

1972 • 27 citations

Determination of therapeutic serum concentrations of oral and parenteral meperidine by gas liquid chromatography

1976 • 24 citations

The Effect of Phenobarbital on the Metabolism of Meperidine in Normal Volunteers

1978 • 23 citations

Pethidine clearance during continuous intravenous infusions in postoperative patients.

1981 • 23 citations

The effects of physicochemical properties of pethidine and its basic metabolites on their buccal absorption and renal elimination

1979 • 23 citations

RELATIONSHIP OF VENTILATORY DEPRESSION TO STEADY-STATE BLOOD PETHIDINE CONCENTRATIONS

1981 • 19 citations

Investigation of the urinary excretion of pethidine and five of its metabolites in man using selected ion monitoring

1980 • 18 citations

Pharmacokinetics of meperidine in man

1976 • 18 citations

Pharmacokinctics of High-Dose Meperidine in Surgical Patients

1982 • 18 citations

The placental transfer of pentazocine and pethidine.

1973 • 17 citations

RATE OF FORMATION OF NORPETHIDINE FROM PETHIDINE

1981 • 13 citations

TLC Identification and GLC Determination of Meperidine and its Metabolites in Biological Fluids

1981 • 11 citations

Brain uptake of meperidine in the fetal lamb

1980 • 10 citations

A Comparison of Alphaprodine and Meperidine Pharmacokinetics

1980 • 7 citations

Potentiation of the analgesia of meperidine in the rat by pargyline.

1979 • 6 citations

Determination of meperidine blood to plasma concentration ratio (lambda) - effect of temperature and pH.

1981 • 2 citations