Effects of anions on the activation thermodynamics and fluorescence emission spectrum of alkaline phosphatase: evidence for enzyme hydration changes during catalysis

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Statistical estimations in enzyme kinetics

1961 • 3,586 citations

Solute perturbation of protein fluorescence. Quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion

1971 • 1,730 citations

Enthalpy–entropy compensation phenomena in water solutions of proteins and small molecules: A ubiquitous properly of water

1970 • 1,173 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

THE STRUCTURE OF WATER AND HYDROPHOBIC BONDING IN PROTEINS. III. THE THERMODYNAMIC PROPERTIES OF HYDROPHOBIC BONDS IN PROTEINS^1,2

1962 • 967 citations

The Kinetic Basis of Molecular Biology

1954 • 535 citations

Pressure denaturation of metmyoglobin

1973 • 475 citations

Mammalian Alkaline Phosphatases

2006 • 413 citations

Fluorescence Polarization: Measurement with Ultraviolet-Polarizing Filters in a Spectrophotofluorometer

1965 • 368 citations

Pressure dependence of weak acid ionization in aqueous buffers

1973 • 358 citations

The Thermodynamics of Protein Denaturation. I. The Denaturation of Chymotrypsinogen

1964 • 328 citations

[87] Fluorescence measurements

1967 • 223 citations

The Thermodynamics of Protein Denaturation. II. A Model of Reversible Denaturation and Interpretations Regarding the Stability of Chymotrypsinogen

1964 • 217 citations

[10] Solute quenching of protein fluorescence

1978 • 201 citations

THE FLUORESCENCE OF NATIVE, DENATURED AND REDUCED‐DENATURED PROTEINS*

1971 • 200 citations

Statistical interpretation of enthalpy–entropy compensation

1976 • 189 citations

Effects of salts on the free energy of the peptide group

1972 • 170 citations

Volume Changes in Hydrocarbon—Water Systems. Partial Molal Volumes of Alcohol—Water Solutions¹

1965 • 153 citations

The Thermodynamic Basis of the Stability of Proteins, Nucleic Acids, and Membranes

1976 • 152 citations

Model studies on the effects of neutral salts on the conformational stability of biological macromolecules. I. Ion binding to polyacrylamide and polystyrene columns

1973 • 141 citations

Phosphorus-31 nuclear magnetic resonance study of alkaline phosphatase: the role of inorganic phosphate in limiting the enzyme turnover rate at alkaline pH

1976 • 137 citations

Effects of the Environment on the Fluorescence of Aromatic Compounds in Solution.

1963 • 133 citations

Effects of salts on the free energies of nonpolar groups in model peptides

1972 • 129 citations

Fluorine-19 nuclear magnetic resonance study of fluorotyrosine alkaline phosphatase: the influence of zinc on protein structure and a conformational change induced by phosphate binding

1976 • 126 citations

Effect of Neutral Salts on Enzyme Activity and Structure^*

1966 • 118 citations

Activation volumes in enzymic catalysis: their sources and modification by low-molecular-weight solutes.

1975 • 117 citations

Assignment of Individual Ionic Contributions to Properties of Aqueous Ions

1964 • 103 citations

Construction and Performance of a Fluorescence Polarization Spectrophotometer

1966 • 101 citations

Protein hydration changes during catalysis: a new mechanism of enzymic rate-enhancement and ion activation/inhibition of catalysis.

1975 • 92 citations

The Effect of Magnesium on Some Physical Properties of Yeast Enolase

1966 • 82 citations

Model studies on the effects of neutral salts on the conformational stability of biological macromolecules. II. Effects of vicinal hydrophobic groups on the specificity of binding of ions to amide groups

1973 • 74 citations

Effects of Pressure and Temperature on the Catalytic and Regulatory Properties of Muscle Pyruvate Kinase from an Off-Shore Benthic Fish

1971 • 63 citations

The influence of pressure on the rates of biological reactions.

1951 • 62 citations

Properties of the Refolding and Unfolding Reactions of Ribonuclease A

1972 • 46 citations

Volume effects in aqueous solutions of macromolecules containing non‐polar groups

1972 • 39 citations

Effects of Hofmeister salts on the self-association of glucagon

1978 • 27 citations

The amino acid sequence around the reactive serine in calf-intestinal alkaline phosphatase

1964 • 23 citations

Neutral salt effects on the velocity and activation volume of the lactate dehydrogenase reaction: Evidence for enzyme hydration changes during catalysis

1977 • 22 citations

Proximity relationships of tryptophanyl residues and oxygen binding site in Levantina hierosolima hemocyanin. A fluorimetric study

1978 • 16 citations

ÉTUDE DES EFFETS ÉLECTROSTATIQUES SUR LE MÉCANISME D'ACTION CATALYTIQUE DE LA PHOSPHATASE ALCALINE INTESTINALE DE VEAU

1965 • 9 citations