Persistent ERK Phosphorylation Negatively Regulates cAMP Response Element-binding Protein (CREB) Activity via Recruitment of CREB-binding Protein to pp90RSK

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Transcriptional regulation by the phosphorylation-dependent factor CREB

2001 • 2,488 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

CREB-binding Protein and p300 in Transcriptional Regulation

2001 • 847 citations

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

1999 • 722 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

1996 • 398 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Phosphorylation of CREB at Ser-133 Induces Complex Formation with CREB-Binding Protein via a Direct Mechanism

1996 • 396 citations

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK

1998 • 359 citations

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

1997 • 355 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c- fos gene

1998 • 302 citations

Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals

1995 • 292 citations

A sensitive method for the detection of beta-galactosidase in transfected mammalian cells.

1991 • 283 citations

The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

1996 • 254 citations

Inhibitors of Cyclin-dependent Kinases Promote Survival of Post-mitotic Neuronally Differentiated PC12 Cells and Sympathetic Neurons

1996 • 252 citations

Nerve Growth Factor Induces Transcription of the p21 WAF1/CIP1 and Cyclin D1 Genes in PC12 Cells by Activating the Sp1 Transcription Factor

1997 • 156 citations

Mitogen-Regulated RSK2-CBP Interaction Controls Their Kinase and Acetylase Activities

2001 • 134 citations

Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo.

1994 • 116 citations

Nerve Growth Factor Up-regulates the Transcriptional Activity of CBP through Activation of the p42/p44MAPK Cascade

1998 • 97 citations

p53 Recruitment of CREB Binding Protein Mediated through Phosphorylated CREB: a Novel Pathway of Tumor Suppressor Regulation

2000 • 79 citations

CREB Binding Protein Recruitment to the Transcription Complex Requires Growth Factor–Dependent Phosphorylation of Its GF Box

2001 • 78 citations

Transient and sustained ERK phosphorylation and nuclear translocation in growth control

2002 • 73 citations

Tyrosine Phosphorylation of the Proto-Oncoprotein Raf-1 Is Regulated by Raf-1 Itself and the Phosphatase Cdc25A

1999 • 53 citations

Cell Growth Inhibition by a Novel Vitamin K Is Associated with Induction of Protein Tyrosine Phosphorylation

1998 • 53 citations

Spatial Analysis of Key Signaling Proteins by High-content Solid-phase Cytometry in Hep3B Cells Treated with an Inhibitor of Cdc25 Dual-specificity Phosphatases

2001 • 44 citations

Tumor cell growth inhibition and extracellular signal-regulated kinase (ERK) phosphorylation by novel K vitamins 1 1Edited by M. Yaniv

2001 • 27 citations

Involvement of hepatocyte epidermal growth factor receptor mediated activation of mitogen-activated protein kinase signaling pathways in response to growth inhibition by a novel K vitamin

2000 • 27 citations

Induction of apoptosis via mitogen-activated protein kinase pathway by a K vitamin analog in rat hepatocytes

2002 • 16 citations

A Cdc25A Antagonizing K Vitamin Inhibits Hepatocyte DNA Synthesis in Vitro and in Vivo

2003 • 15 citations