Epidermal Growth Factor Receptor Tyrosine Kinase as a Target for Anticancer Therapy

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

The Epidermal Growth Factor Receptor and Its Inhibition in Cancer Therapy

1999 • 840 citations

Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

1997 • 828 citations

EGF receptor

1999 • 792 citations

The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

1992 • 585 citations

Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.

2000 • 505 citations

Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin.

1995 • 391 citations

Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy.

1997 • 314 citations

ZD1839 (???Iressa???)*,??? as an Anticancer Agent

2000 • 298 citations

Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis

1998 • 263 citations

The prognostic value of epidermal growth factor receptor mRNA expression in primary ovarian cancer

1996 • 210 citations

Tyrosine Kinase Inhibitors Targeted to the Epidermal Growth Factor Receptor Subfamily

2000 • 170 citations

Inhibition of the Epidermal Growth Factor Receptor Family of Tyrosine Kinases as an Approach to Cancer Chemotherapy

1999 • 128 citations

The type I growth factor receptors in human breast cancer

1994 • 127 citations

The prognostic value of epidermal growth factor receptor (EGF-R) in primary breast cancer: Results of a 10 year follow-up study

1994 • 124 citations

Epidermal growth factor, oestrogen and progesterone receptor expression in primary ovarian cancer: correlation with clinical outcome and response to chemotherapy

1995 • 102 citations

The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities

1994 • 97 citations

Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives.

1996 • 95 citations

The Rationale and Strategy Used to Develop a Series of Highly Potent, Irreversible, Inhibitors of the Epidermal Growth Factor Receptor Family of Tyrosine Kinases

1999 • 92 citations

Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells.

1996 • 89 citations

The rationale and strategy used to develop a series of highly potent, irreversible, inhibitors of the epidermal growth factor receptor family of tyrosine kinases.

1999 • 87 citations

Epidermal growth factor receptor: Elements of intracellular communication

1992 • 83 citations

Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells☆☆☆

1998 • 80 citations

Abrogation of Cisplatin-Induced Programmed Cell Death in Human Breast Cancer Cells by Epidermal Growth Factor Antisense RNA

1997 • 74 citations

Structure, function and transforming potential of the epidermal growth factor receptor

1990 • 64 citations

Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor

1995 • 59 citations

Targeting the epidermal growth factor receptor for therapy of carcinomas

1996 • 57 citations

Epidermal growth factor: the receptor and its function.

1989 • 47 citations

EGF-R expression in ductal breast cancer: proliferation and prognostic implications.

1997 • 47 citations

EGF‐R and Overexpression of the Oncogene c‐erbB‐2 in Ovarian Cancer: Immunohistochemical Findings and Prognostic Value

1995 • 43 citations

Increased epidermal growth factor receptor in an estrogen‐responsive, adriamycin‐resistant MCF‐7 cell line

1993 • 37 citations

Enhancement of drug sensitivity of human malignancies by epidermal growth factor

1995 • 36 citations