Antituberculosis drugs and hepatotoxicity

Incidence of Serious Side Effects from First-Line Antituberculosis Drugs among Patients Treated for Active Tuberculosis

2003 • 816 citations

Hepatotoxicity Associated With Isoniazid Preventive Therapy

1999 • 469 citations

Polymorphism of theN-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis

2002 • 423 citations

Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis

2003 • 414 citations

Isoniazid-Associated Hepatitis in 114 Patients

1975 • 372 citations

Evaluation of Clinical and Immunogenetic Risk Factors for the Development of Hepatotoxicity during Antituberculosis Treatment

2002 • 324 citations

Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites

1975 • 301 citations

Risk factors for hepatotoxicity from antituberculosis drugs: a case-control study.

1996 • 240 citations

Pharmacokinetics of isoniazid metabolism in man

1976 • 183 citations

Increased risk of antituberculosis drug‐induced hepatotoxicity in individuals with glutathione S‐transferase M1 ‘null’ mutation

2001 • 182 citations

Controlling Tuberculosis in India

2002 • 168 citations

Hepatic toxicity in south indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide

1986 • 152 citations

Acetylation Rates and Monthly Liver Function Tests during One Year of Isoniazid Preventive Therapy

1975 • 122 citations

Rifampin-induced release of hydrazine from isoniazid. A possible cause of hepatitis during treatment of tuberculosis with regimens containing isoniazid and rifampin.

1986 • 115 citations

Study of Oxidative-Stress in Isoniazid-Rifampicin Induced Hepatic Injury in Young Rats

1997 • 112 citations

Plasma Hydrazine Concentrations in Man after Isoniazid and Hydralazine Administration

1985 • 97 citations

An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes

2000 • 90 citations

Lack of relationship between hepatic toxicity and acetylator phenotype in three thousand South Indian patients during treatment with isoniazid for tuberculosis.

1984 • 82 citations

Antituberculosis treatment-induced hepatotoxicity: role of predictive factors

1995 • 79 citations

Risk factors for antituberculous chemotherapy‐induced hepatotoxicity in Japanese pediatric patients

2002 • 69 citations

Hepatotoxicity caused by the combined action of isoniazid and rifampicin.

1995 • 51 citations

Hepatitis cases in isoniazid treated groups and in a control group.

1976 • 49 citations

Hepatotoxic reactions in children with severe tuberculosis treated with isoniazid-rifampin

1985 • 42 citations

Relationship of acetylator status to isoniazid toxicity, lupus erythematosus, and bladder cancer.

1983 • 41 citations

Tolerance of pyrazinamide in short course chemotherapy for pulmonary tuberculosis in children

1997 • 33 citations

Anti tubercular treatment induced hepatotoxicity: does acetylator status matter?

1995 • 18 citations