The Biological Activity of Nonsteroidal Vitamin D Hormone Analogs Lacking Both the C- and D-Rings

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

1981 • 1,025 citations

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

1988 • 961 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

Newly Identified Actions of the Vitamin D Endocrine System*

1992 • 563 citations

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells.

1984 • 461 citations

Steroid Hormone Receptors

1976 • 345 citations

20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses

1991 • 320 citations

Immunomodulatory role of 1,25‐dihydroxyvitamin D₃

1992 • 302 citations

Vitamin D, Calcium, and Epidermal Differentiation*

1993 • 287 citations

Structure-function relationships in the vitamin D endocrine system

1995 • 268 citations

Vitamin D. Gene Regulation, Structure-Function Analysis and Clinical Application

1991 • 230 citations

CLINICAL COUNTERPOINT: Vitamin D: New Actions, New Analogs, New Therapeutic Potential*

1992 • 223 citations

Ketoconazole and Other Imidazole Derivatives as Inhibitors of Steroidogenesis

1986 • 216 citations

Distinct Conformational Changes Induced by 20-epi Analogues of 1α,25-Dihydroxyvitamin D3 Are Associated with Enhanced Activation of the Vitamin D Receptor

1995 • 201 citations

Interaction of 1,25-Dihydroxyvitamin-D₃with Keratinocytes and Fibroblasts from Skin of Normal Subjects and a Subject with Vitamin-D-Dependent Rickets, Type II: A Model for Study of the Mode of Action of 1,25-Dihydroxyvitamin D₃*

1983 • 196 citations

Separation of the epidermal sheet by dispase

1983 • 187 citations

Vitamin D, a pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications

1994 • 176 citations

A Novel Vitamin D₃Analog, 22-Oxa-1, 25- Dihydroxyvitamin D₃, Inhibits the Growth of Human Breast Cancerin Vitroandin Vivowithout Causing Hypercalcemia*

1991 • 175 citations

1α,25-dihydroxy-19-nor-vitamin D3, a novel vitamin D-related compound with potential therapeutic activity

1990 • 161 citations

The Vitamin D-Responsive Element in the Rat Bone Gla Protein Gene Is an Imperfect Direct Repeat That Cooperates with Other Cis-Elements in 1,25-Dihydroxyvitamin D₃- Mediated Transcriptional Activation

1991 • 148 citations

Synthetic analogues of vitamin D₃ with an oxygen atom in the side chain skeleton A trial of the development of vitamin D compounds which exhibit potent differentiation‐inducing activity without inducing hypercalcemia

1987 • 135 citations

Vitamin D analogs with low affinity for the vitamin D binding protein: Enhanced in vitro and decreased in vivo activity

1991 • 124 citations

Comparative study of the affinity of the serum vitamin d-binding protein

1980 • 121 citations

A SYNTHETIC ANALOGUE OF VITAMIN D₃, 22-OXA-lα,25-DIHYDROXYVITAMIN D₃IS A POTENT MODULATOR OF IN VIVO IMMUNOREGULATING ACTIVITY WITHOUT INDUCING HYPERCALCEMIA IN MICE

1989 • 106 citations

26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3: A highly potent, long-lasting analog of 1,25-dihydroxyvitamin D3

1984 • 105 citations

Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism

1991 • 92 citations

Binding proteins of steroid hormones

1987 • 91 citations

Structure-function studies of 1,25-dihydroxyvitamin D3 and the vitamin D endocrine system. 1,25-dihydroxy-pentadeuterio-previtamin D3 (as a 6-s-cis analog) stimulates nongenomic but not genomic biological responses

1993 • 89 citations

1α,25(OH)2Vitamin D3-Regulated Expression of the Eukaryotic Genome

2009 • 89 citations

24- and 26-homo-1,25-dihydroxyvitamin D3: preferential activity in inducing differentiation of human leukemia cells HL-60 in vitro.

1987 • 87 citations

Vitamin D and its analogs. VII. Solution conformations of vitamin D3 and 1.alpha.,25-dihydroxyvitamin D3 by high-resolution proton magnetic resonance spectroscopy

1975 • 86 citations

Profile of ligand specificity of the vitamin D binding protein for 1α,25-dihydroxyvitamin d3 and its analogs

1994 • 80 citations

Studies of vitamin D (calciferol) and its analogs. 35. Synthesis and biological activity of 9,11-dehydrovitamin D3 analogs: stereoselective preparation of 6.beta.-vitamin D vinylallenes and a concise enynol synthesis for preparing the A-ring

1989 • 74 citations

1,25-Dihydroxyvitamin D3 analog structure-function assessment of the rapid stimulation of intestinal calcium absorption (transcaltachia)

1992 • 74 citations

24-Homologated 1,25-dihydroxyvitamin D3 compounds: separation of calcium and cell differentiation activities

1990 • 72 citations

Antiandrogenic drugs

1993 • 71 citations

Aromatase and its inhibitors—an overview

1991 • 69 citations

Immunomodulating properties of 1,25-dihydroxyvitamin D3.

1990 • 68 citations

Homologous Radioimmunoassay of Human Osteocalcin

1992 • 65 citations

The vitamin D system: 1990.

1990 • 64 citations

Vitamin D, calcium, and epidermal differentiation

1993 • 62 citations

A dialogue on analogues Newer vitamin-D drugs for use in bone disease, psoriasis, and cancer

1993 • 56 citations

An evaluation of 1,25-dihydroxyvitamin D3 analogues on the proliferation and differentiation of cultured human keratinocytes, calcium metabolism and the differentiation of human HL-60 cells

1993 • 52 citations

Biological activity of fluorinated vitamin D analogs at C-26 and C-27 on human promyelocytic leukemia cells, HL-60

1987 • 47 citations

1β, 25(OH)2-vitamin D3 is an antagonist of 1α,25(OH)2-vitamin D3 stimulated transcaltachia (The rapid hormonal stimulation of intestinal calcium transport)

1992 • 46 citations

Non-hypercalcemic pharmacological aspects of vitamin D analogs

1995 • 45 citations

Synthesis of CD-ring modified 1α,25-dihydroxy vitamin D analogues : E-ring analogues

1996 • 40 citations

Structure function analysis of vitamin D analogs with C-ring modifications.

1992 • 39 citations

Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential

1992 • 39 citations

14-Epi Stereoisomers of 25-Hydroxy- and 1.alpha.,25-Dihydroxyvitamin D3: Synthesis, Isomerization to Previtamins, and Biological Studies

1994 • 38 citations

Biologic activity of dihydroxylated 19-nor-(pre)vitamin D3

1993 • 37 citations

Conformational analysis of 1α,25-dihydroxyvitamin D3 by nuclear magnetic resonance

1990 • 26 citations

A chemical classification of nonsteroidal antagonists of sex-steroid hormone action

1988 • 20 citations

A proton magnetic resonance nuclear Overhauser enhancement study. Application to vitamin D derivatives D₂ and D₃

1980 • 13 citations

Synthesis and biological activities of 8(14)a-homocalcitriol

1992 • 12 citations

Purification of the serum vitamin D-binding protein (DBP) from different species

1986 • 7 citations

Remembrance: discovery of the vitamin D endocrine system.

1992 • 7 citations

Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells

1994 • 5 citations

Remembrance: discovery of the vitamin D endocrine system

1992 • 4 citations