The Pathophysiology of Pneumococcal Meningitis

Adhesion receptors of the immune system

1990 • 6,585 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Acute Bacterial Meningitis in Adults -- A Review of 493 Episodes

1993 • 1,321 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

The Significance of Pneumococcal Types

1928 • 1,043 citations

The significance of penumococcal types

1966 • 992 citations

Epidemiologic Studies of Streptococcus pneumoniae in Infants: Acquisition, Carriage, and Infection during the First 24 Months of Life

1980 • 804 citations

Dexamethasone Therapy for Bacterial Meningitis

1988 • 614 citations

Infections Caused by Streptococcus pneumoniae: Clinical Spectrum, Pathogenesis, Immunity, and Treatment

1992 • 522 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

The Beneficial Effects of Early Dexamethasone Administration in Infants and Children with Bacterial Meningitis

1991 • 490 citations

Bacterial Meningitis: Pathogenesis, Pathophysiology, and Progress

1992 • 488 citations

Bacterial Meningitis in the United States, 1986: Report of a Multistate Surveillance Study

1990 • 472 citations

Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response.

1989 • 461 citations

Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

1989 • 404 citations

Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids.

1988 • 396 citations

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

1991 • 375 citations

The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis.

1990 • 367 citations

The Induction of Meningeal Inflammation by Components of the Pneumococcal Cell Wall

1985 • 358 citations

Bacterial Meningitis in the United States, 1978 Through 1981

1985 • 350 citations

Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils.

1991 • 347 citations

Prospective Evaluation of Hearing Impairment as a Sequela of Acute Bacterial Meningitis

1984 • 345 citations

Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes.

1989 • 339 citations

Horizontal transfer of multiple penicillin‐binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae

1991 • 315 citations

Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation.

1990 • 296 citations

THE IgA1 PROTEASES OF PATHOGENIC BACTERIA

1983 • 290 citations

Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis

1989 • 278 citations

Penicillin-binding proteins of multiply antibiotic-resistant South African strains of Streptococcus pneumoniae

1980 • 271 citations

Dexamethasone treatment for bacterial meningitis in children and adults

1989 • 269 citations

Effects of Ampicillin and Corticosteroids on Brain Water Content, Cerebrospinal Fluid Pressure, and Cerebrospinal Fluid Lactate Levels in Experimental Pneumococcal Meningitis

1985 • 261 citations

Cephalosporin treatment failure in penicillin- and cephalosporin-resistant Streptococcus pneumoniae meningitis.

1992 • 260 citations

Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells.

1983 • 248 citations

Some aspects of the pneumococcal carrier state

1986 • 222 citations

Cerebrospinal fluid outflow resistance in rabbits with experimental meningitis. Alterations with penicillin and methylprednisolone.

1980 • 213 citations

Antibiotic Therapy, Endotoxin Concentration in Cerebrospinal Fluid, and Brain Edema in Experimental Escherichia coli Meningitis in Rabbits

1987 • 166 citations

Production of interleukin-1 but not tumor necrosis factor by human monocytes stimulated with pneumococcal cell surface components

1989 • 164 citations

Nonsteroidal Anti-Inflammatory Agents in the Therapy for Experimental Pneumococcal Meningitis

1987 • 161 citations

Extensive re‐modelling of the transpeptidase domain of penicillin‐binding protein 2B of a penicillin‐resistant South African isolate of Streptococcus pneumoniae

1989 • 155 citations

A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci.

1990 • 146 citations

Cerebrospinal Fluid Cachectin/Thmor Necrosis Factor- and Platelet-Activating Factor Concentrations and Severity of Bacterial Meningitis in Children

1990 • 141 citations

Pathogenic Events During Infection of the Human Nasopharynx with Neisseria meningitidis and Haemophilus influenzae

1990 • 138 citations

Inhibition of leukocyte rolling with polysaccharide fucoidin prevents pleocytosis in experimental meningitis in the rabbit.

1994 • 134 citations

Loss of cerebrovascular autoregulation in experimental meningitis in rabbits.

1990 • 130 citations

Drug Resistance Patterns and Serogroups or Serotypes of Pneumococcal Isolates from Cerebrospinal Fluid or Blood, 1979-1986

1988 • 123 citations

Structure of the peptide network of pneumococcal peptidoglycan.

1987 • 118 citations

Tumor Necrosis Factor- (TNF ) in Cerebrospinal Fluid from Patients with Meningitis of Different Etiologies: High Levels of TNF Indicate Bacterial Meningitis

1993 • 115 citations

Penicillin-binding proteins of penicillin-susceptible and -resistant pneumococci: immunological relatedness of altered proteins and changes in peptides carrying the beta-lactam binding site

1986 • 105 citations

Macrophages in the central nervous system of the rat

1987 • 100 citations

Haemophilus influenzae Type b Lipooligosaccharide Induces Meningeal Inflammation

1988 • 100 citations

Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus meningitis.

1991 • 99 citations

Differing roles for platelet-activating factor during inflammation of the lung and subarachnoid space. The special case of Streptococcus pneumoniae.

1992 • 97 citations

The cell wall mediates pneumococcal attachment to and cytopathology in human endothelial cells

1993 • 97 citations

Genetic identification of exported proteins in Streptococcus pneumoniae

1993 • 93 citations

Dexamethasone in the Treatment of Experimental Haemophilus influenzae Type b Meningitis

1987 • 83 citations

Temperature-dependent modulation of lipopolysaccharide-induced interleukin-1 beta and tumor necrosis factor alpha expression in cultured human astroglial cells by dexamethasone and indomethacin.

1991 • 82 citations

Measurement of Levels of Tumor Necrosis Factor- and Interleukin-1 in the CSF of Patients with Meningitis of Different Etiologies: Utility in the Differential Diagnosis

1993 • 78 citations

Microbiological and Clinical Significance of a New Property of Defective Lysis in Clinical Strains of Pneumococci

1988 • 67 citations

Differences of Pathophysiology in Experimental Meningitis Caused by Three Strains of Streptococcus Pneumoniae

1991 • 67 citations

Serotypes Responsible for Invasive Streptococcus pneumoniae Infections among Children in Connecticut

1994 • 65 citations

The interaction of C3b bound to pneumococci with factor H (beta 1H globulin), factor I (C3b/C4b inactivator), and properdin factor B of the human complement system.

1983 • 64 citations

Pentoxifylline modulates meningeal inflammation in experimental bacterial meningitis

1990 • 61 citations

Cerebrospinal Fluid Protein Profile in Experimental Pneumococcal Meningitis and Its Alteration by Ampicillin and Anti-Inflammatory Agents

1989 • 55 citations

The nature of cell wall-derived inflammatory components of pneumococci

1989 • 49 citations

Experimental pneumococcal meningitis. IV. The effect of methyl prednisolone on meningeal inflammation.

1978 • 45 citations

Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988.

1986 • 41 citations

Identification of atypical strains ofStreptococcus pneumoniae by a specific DNA probe

1990 • 40 citations

Antiinflammatory Effects in Experimental Meningitis of Prokaryotic Peptides that Mimic Selectins

1993 • 37 citations

LACK OF ADVERSE EFFECTS OF DEXAMETHASONE THERAPY IN ASEPTIC MENINGITIS

1990 • 32 citations

Analogs of platelet activating factor. 4. Some modifications of the phosphocholine moiety

1986 • 31 citations

Brain edema and increased intracranial pressure in the pathophysiology of bacterial meningitis

1989 • 31 citations

Effect of Indomethacin on the Pathophysiology of Experimental Meningitis in Rabbits

1991 • 28 citations

TYPE DISTRIBUTION AND ANTIBIOTIC SENSITIVITY OF DIPLOCOCCUS PNEUMONIAE A FIVE‐YEAR STUDY IN SYDNEY

1974 • 27 citations

Therapy of Penicillin- and Cephalosporin-resistant Pneumococcal Infections

1993 • 14 citations

Intracranial pressure and cerebral perfusion pressure in experimentalstreptococcus pneumoniae meningitis

1992 • 6 citations

Haemophilus influenzae virulence factors in experimental meningitis

1989 • 5 citations

Brain Levels of neuropeptide Y in experimental pneumococcal meningitis

1993 • 5 citations