Rabbit hepatocytes in primary culture: Preparation, viability and use in studies of propranolol metabolism

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Reduction of Liver Blood Flow and Propranolol Metabolism by Cimetidine

1981 • 379 citations

Detection of a Liver-Membrane Autoantibody in HBsAg-negative Chronic Active Hepatitis

1976 • 270 citations

Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.

1972 • 180 citations

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

1989 • 178 citations

Isolated rat hepatocyte couplets in short-term culture: Structural characteristics and plasma membrane reorganization

1987 • 145 citations

Primary cultures and the levels of cytochromeP450 in hepatocytes from mouse, rat, hamster, and rabbit liver

1982 • 139 citations

Pharmacology of 4‐hydroxypropranolol, a metabolite of propranolol

1971 • 124 citations

Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects

1989 • 118 citations

Quantitative account of propranolol metabolism in urine of normal man.

1985 • 117 citations

Kinetics of serum protein secretion by cultured hepatoma cells. Evidence for multiple secretory pathways.

1983 • 102 citations

Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade

1984 • 81 citations

Attachment and long term survival of adult rat hepatocytes in primary monolayer cultures: Comparison of different substrata and tissue culture media formulations

1986 • 79 citations

Biologic determinants of propranolol disposition: Results from 1308 patients in the beta-blocker heart attack trial*

1985 • 77 citations

Inhibition of propranolol metabolism by chlorpromazine

1979 • 75 citations

4-Hydroxypropranolol and its glucuronide after single and long-term doses of propranolol

1980 • 70 citations

Stereoselective ring oxidation of propranolol in man.

1984 • 67 citations

The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol.

1984 • 66 citations

Cimetidine increases steady state plasma levels of propranolol.

1981 • 65 citations

Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites.

1987 • 62 citations

Quantitative metabolic fate of propranolol in the dog, rat, and hamster using radiotracer, high performance liquid chromatography, and gas chromatography-mass spectrometry techniques.

1983 • 44 citations

Binding properties of mechanically and enzymatically isolated hepatocytes for IgG and C3

1983 • 42 citations

New ring-hydroxylated metabolites of propranolol: species differences and stereospecific 7-hydroxylation.

1982 • 36 citations

The role of the carbohydrate moiety in the biologic properties of fibrinogen.

1984 • 26 citations

Effect of different collagenases on the isolation of viable hepatocytes from rat liver

1984 • 19 citations

Influence of debrisoquin phenotype on the inducibility of propranolol metabolism

1989 • 18 citations

Chemical trapping of labile aldehyde intermediates in the metabolism of propranolol and oxprenolol.

1981 • 13 citations

Isolation, purification, and structure identification of glucuronic acid conjugates of propranolol and alprenolol and their ring-hydroxylated metabolites.

1984 • 9 citations