The Selective α2-Adrenoceptor Antagonist Mirtazapine (Org 3770) Enhances Noradrenergic and 5-HT1A-Mediated Serotonergic Neurotransmission

Current advances and trends in the treatment of depression

1994 • 1,111 citations

Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists

1980 • 435 citations

Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro.

1984 • 313 citations

Pharmacokinetics of antidepressants: why and how they are relevant to treatment.

1993 • 269 citations

The Pharmacologic Treatment of Depression

1991 • 200 citations

Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers

1988 • 182 citations

Monoamines and Abnormal Behaviour a Multi-Aminergic Perspective

1990 • 175 citations

Selective activation of 5HT1A receptors induces lower lip retraction in the rat

1989 • 161 citations

Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants.

1993 • 158 citations

Current status of antidepressants: clinical pharmacology and therapy.

1989 • 149 citations

Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat

1989 • 139 citations

Behavioural evidence for functional interactions between 5‐HT‐receptor subtypes in rats and mice

1990 • 133 citations

Fluoxetine: a five-year review.

1993 • 124 citations

Effect of the antidepressant Org 3770 on human sleep

1990 • 107 citations

The α2-adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo

1994 • 104 citations

In vivo electrophysiological evidence for tonic activation by endogenous noradrenaline of α2-adrenoceptors on 5-hydroxytryptamine terminals in the rat hippocampus

1993 • 102 citations

α1-Adrenoceptor antagonists differentially control serotonin release in the hippocampus and striatum: a microdialysis study

1994 • 86 citations

The comparative pharmacology of new antidepressants.

1993 • 85 citations

Electrophysiologic Evidence for Desensitization of α2-Adrenoceptors on Serotonin Terminals Following Long-Term Treatment with Drugs Increasing Norepinephrine Synaptic Concentration

1994 • 85 citations

The effect of adrenergic drugs on serotonin metabolism in the nucleus raphe dorsalis of the rat, studied by in vivo voltammetry

1992 • 64 citations

Beyond the serotonin reuptake inhibitors: rationales for the development of new serotonergic agents.

1994 • 63 citations

Biological basis of depression and therapeutic relevance.

1991 • 60 citations

Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells

1994 • 55 citations

A double-blind comparison of moclobemide and fluoxetine in the treatment of depressive disorders

1993 • 53 citations

Serotonin Syndrome

1994 • 45 citations

Actions and Interactions of Psychotropic Drugs on Human Performance and Mood: Single Doses of ORG 3770, Amitriptyline, and Diazepam

1989 • 42 citations

Safety and Efficacy During Long-Term Treatment with Moclobemide

1994 • 30 citations

Computer-Based Prediction of Psychotropic Drug Classes Based on a Discriminant Analysis of Drug Effects on Rat Sleep

1993 • 25 citations

Cross-familiarisation conditioned taste aversion procedure as a method to reveal stimulus resemblance between drugs: studies on the 5-HT1A agonist 8-OHDPAT

1993 • 25 citations

Effects of imipramine and mirtazapine on operant performance in rats

1994 • 19 citations

Serotonergic mechanisms and the new antidepressants

1993 • 17 citations

A set of behavioural tests predicting antidepressant activity

1985 • 15 citations

The effect of a number of drugs with different pharmacological properties upon reserpine induced hypothermia in mice.

1971 • 14 citations

Pharmacological evaluation of in vivo tests for alpha 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza-analog ORG 3770.

1988 • 12 citations

Electrophysiological and biochemical characterization of the development of α1-adrenergic and 5-HT1 receptors associated with dorsal raphe neurons

1989 • 11 citations

Antidepressant characteristics of Org 3770, Org 4428 and Org 9768 on rat sleep

1990 • 10 citations

P-2-93 Down regulation of 5-HT2A receptors after chronic treatment with remeron

1995 • 6 citations