Multimeric cytokine receptors

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

1993 • 771 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

Receptors for the TGF-β family

1992 • 638 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

1993 • 541 citations

Steel locus defines new multipotent growth factor

1990 • 509 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

1993 • 383 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Colony-stimulating factor-1 receptor

1990 • 362 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor

1993 • 283 citations

Cytokine receptors and signal transduction

1992 • 269 citations

The Many Roads That Lead to Ras

1993 • 185 citations

Purification and characterization of the receptor for murine granulocyte colony-stimulating factor.

1990 • 180 citations

c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.

1993 • 170 citations

Receptors for the TGF-β superfamily: multiple polypeptides and serine/threonine kinases

1993 • 164 citations

Distinct Regions of the Human Granulocyte-Colony-Stimulating Factor Receptor Cytoplasmic Domain Are Required for Proliferation and Gene Induction

1993 • 138 citations

Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.

1993 • 132 citations

Common subunits of cytokine receptors and the functional redundancy of cytokines

1992 • 131 citations

Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

1993 • 114 citations

The amino-terminal helix of GM-CSF and IL-5 governs high affinity binding to their receptors.

1991 • 103 citations

A Model for the Interaction of the GM-CSF, IL-3 and IL-5 Receptors with their Ligands

1993 • 92 citations

Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction.

1993 • 71 citations

Interleukin 5 and interleukin 3 induce serine and tyrosine phosphorylations of several cellular proteins in an interleukin 5-dependent cell line

1990 • 65 citations

Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential

1993 • 26 citations

Cytokine receptors

1991 • 16 citations

Regulation of SRC-family protein tyrosine kinases by interleukins, IL-2, and IL-3.

1992 • 9 citations