Biliary Excretion of Metals

Handbook of Physiology.

1960 • 10,428 citations

Cadmium in the environment

1971 • 1,570 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

Metallothionein: a Cadmium- and Zinc-containing Protein from Equine Renal Cortex

1960 • 965 citations

Metallothionein: a Cadmium and Zinc-containing Protein from Equine Renal Cortex

1961 • 685 citations

Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions

1969 • 589 citations

The Pharmacology of Mercury Compounds

1972 • 413 citations

Equine Hepatic and Renal Metallothioneins

1974 • 384 citations

The liver: quantitative aspects of structure and function

1973 • 369 citations

Isolation and Some Properties of Human Metallothionein^*

1966 • 326 citations

Influence of First-Pass Effect on Availability of Drugs on Oral Administration

1971 • 264 citations

Binding of cadmium ions by rat liver and kidney

1972 • 261 citations

Separation of two forms of rabbit metallothionein by isoelectric focusing

1972 • 247 citations

Human hepatic metallothioneins

1974 • 238 citations

Role of liver in regulating distribution and excretion of manganese

1966 • 229 citations

Intestinal Transport of²⁰³Hg-Labeled Methyl Mercury Chloride

1971 • 219 citations

Protection by zinc against cadmium toxicity

1972 • 211 citations

Mechanism of phenobarbital-induced hypercholeresis in the rat

1970 • 209 citations

Canalicular bile production in dogs

1968 • 209 citations

Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis

1971 • 207 citations

Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: Induction of metallothionein by mercury and cadmium

1974 • 206 citations

Characterization of Cd, Zn‐Thionein (Metallothionein) Isolated from Rat and Chicken Liver

1973 • 199 citations

The Disposition of Propranolol

1972 • 188 citations

The Excretory Function of Bile

1977 • 172 citations

Distribution of Cadmium Among Protein Fractions of Mouse Liver¹)

1971 • 167 citations

Purification and some properties of Cd-binding protein from rat liver

1972 • 167 citations

Two Sites of Bile Formation as Determined by Mannitol and Erythritol Clearance in the Guinea Pig*

1967 • 165 citations

Initial distribution and rate of uptake of sulfobromophthalein in the liver

1964 • 164 citations

Biliary excretion of injected conjugated and unconjugated bilirubin by normal and Gunn rats

1961 • 151 citations

Factors determining the maximal rate of organic anion secretion by the liver and further evidence on the hepatic site of action of the hormone secretin

1966 • 149 citations

The isolation of metallothionein and its protective role in cadmium poisoning

1974 • 148 citations

STUDIES IN MINERAL METABOLISM WITH THE AID OF ARTIFICIAL RADIOACTIVE ISOTOPES

1943 • 140 citations

THE INFLUENCE OF ENTEROHEPATIC CIRCULATION ON TOXICITY OF DRUGS*

1965 • 128 citations

Canalicular bile formation in the isolated perfused rat liver

1971 • 128 citations

Immunological Studies of Y Protein. A MAJOR CYTOPLASMIC ORGANIC ANION-BINDING PROTEIN IN RAT LIVER

1972 • 127 citations

Biliary excretion of manganese in rats, rabbits, and dogs*1

1974 • 124 citations

Isolation of cadmium-binding proteins

1971 • 122 citations

Effect of phenobarbital on bile flow and bile salt excretion in the rat

1971 • 121 citations

Virtual absence of turnover in cadmium metabolism: Cd¹⁰⁹ studies in the mouse

1961 • 120 citations

MECHANISMS OF BILE SECRETION

1959 • 119 citations

Multiplicity of Hepatic Excretory Mechanisms for Organic Anions

1969 • 116 citations

Effect of phenobarbital on the excretion of an exogenous bilirubin load

1967 • 114 citations

Studies on the mechanism of phenobarbital-enhanced sulfobromophthalein disappearance.

1968 • 109 citations

Deficiency of Hepatic Organic Anion-Binding Protein, Impaired Organic Anion Uptake by Liver and Physiologic Jaundice in Newborn Monkeys

1970 • 109 citations

Maximum Biliary Excretion of Bilirubin and Sulfobromophthalein During Anesthesia-Induced Alteration of Rectal Temperature.

1967 • 101 citations

A study of the distribution and retention of cadmium-115 in the albino rat

1957 • 98 citations

Biliary flow after microsomal enzyme induction.

1969 • 97 citations

Biliary excretion in foreign compounds. Species difference in biliary excretion

1967 • 96 citations

Primate Biliary Physiology VIII. THE EFFECT OF PHENOBARBITAL UPON BILE SALT SYNTHESIS AND POOL SIZE, BILIARY LIPID SECRETION, AND BILE COMPOSITION

1973 • 96 citations

Absorption, distribution and excretion of inorganic tin in rats

1974 • 95 citations

Conversion of metallothionein into Cu‐thionein, the possible low molecular weight form of neonatal hepatic mitochondrocuprein

1974 • 95 citations

Nature and Origin of the Proteins of Bile

1974 • 92 citations

Excretion and Absorption of Methyl Mercury After Polythiol Eesin Treatment

1973 • 92 citations

Changes in liver blood flow during enzyme induction

1971 • 91 citations

Biliary excretion of inulin, sucrose, and mannitol: analysis of bile formation

1961 • 90 citations

Active transport of zinc and identification of zinc-binding protein in rat jejunal mucosa

1974 • 90 citations

Active transport of quaternary ammonium compounds into bile

1963 • 87 citations

Binding of cadmium and mercury by metallothionein in the kidneys and liver of rats following repeated administration

1974 • 86 citations

Kinetics of the Distribution and Excretion of Lead in the Rat

1964 • 82 citations

Biliary excretion of arsenic in rats, rabbits, and dogs*1

1974 • 80 citations

ORGANIC ANION-BINDING PROTEIN IN RAT LIVER: DRUG INDUCTION AND ITS PHYSIOLOGIC CONSEQUENCE

1969 • 77 citations

The hemodynamic effects of beta adrenergic blockade on the flow-dependent hepatic clearance of propranolol.

1973 • 76 citations

Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.

1974 • 75 citations

Biliary secretion of ouabain-3H and its uptake by liver slices in the rat

1968 • 72 citations

Absorption and excretion of Cu⁶⁴-labeled copper by the rat

1964 • 72 citations

Biliary excretion of 203Hg, 64Cu, 52Mn, and 210Pb in the rat

1972 • 71 citations

Plasma disappearance and biliary excretion of indocyanine green in rats, rabbits, and dogs

1969 • 67 citations

Oral absorption and disposition kinetics of lidocaine hydrochloride in dogs.

1970 • 67 citations

DEFICIENCY OF HEPATIC ORGANIC ANION-BINDING PROTEIN AS A POSSIBLE CAUSE OF NON-HÆMOLYTIC UNCONJUGATED HYPERBILIRUBINÆMIA IN THE NEWBORN

1969 • 64 citations

The Clearance of Mannitol and Erythritol In Rat Bile.

1967 • 63 citations

Biliary excretion of lead in rats rabbits, and dogs*1

1974 • 61 citations

Origin and Nature of the Proteins of Bile

1974 • 61 citations

MANGANESE: ITS DISTRIBUTION, PHARMACOLOGY AND HEALTH HAZARDS

1935 • 60 citations

Phylogenetic Study of Organic Anion Transfer from Plasma into the Liver

1971 • 56 citations

Cadmium‐induced synthesis of hepatic metallothionein in chicken and rats

1973 • 54 citations

The effect of 2,4‐dinitrophenol and related compounds on bile secretion

1968 • 53 citations

Nature of copper compounds in liver supernate and bile of rats: studies with 67 Cu

1973 • 52 citations

Mercury Poisoning: Prevention by Spironolactone

1970 • 51 citations

Hepatic disposition of phenoldibromphthalein disulfonate and sulfobromophthalein

1968 • 50 citations

The absorption, metabolism and excretion of disodium cromoglycate in nine animal species

1973 • 49 citations

The almost complete hepatic extraction of propranolol during intravenous administration in the dog

1971 • 49 citations

Studies in Mineral Metabolism with the Aid of Induced Radioactive Isotopes

1940 • 48 citations

Zinc metabolism in the rat. II. Secretion of zinc into intestine.

1973 • 48 citations

Bile Flow and Composition During Bile Acid Depletion and Administration

1974 • 48 citations

Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction

1970 • 46 citations

The Effect of Physical Environmental Factors on Drug Response

1972 • 46 citations

STUDIES ON THE METABOLISM OF ZINC WITH THE AID OF ITS RADIOACTIVE ISOTOPE

1943 • 45 citations

Gas-liquid-chromatographic determination of bile acids in bile

1971 • 45 citations

Abnormalities of the Physiology of Copper in Wilson's Disease

1971 • 44 citations

Metabolism of cu-64-labeled copper by the isolated rat liver

1966 • 44 citations

HEPATIC TRANSPORT OF BILIRUBIN

1963 • 43 citations

Congenital photosensitivity and hyperbilirubinemia in Southdown sheep in the United States.

1968 • 42 citations

Biliary excretion of mercury compounds

1975 • 41 citations

BIOCHEMICAL EFFECTS OF Cd2+-INJURY IN THE RAT AND MOUSE TESTIS

1972 • 41 citations

Biliary excretion of cardiac glycosides.

1973 • 39 citations

The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog.

1971 • 38 citations

Canalicular Bile Flow and Bromosulfophthalein Transport Maximum: The Effect of a Bile Salt-Independent Choleretic, Sc-2644

1974 • 37 citations

THE LOSS OF PROTEIN IN HUMAN AND CANINE HEPATIC BILE.

1964 • 37 citations

Route of administration and drug metabolism

1972 • 36 citations

Effect of Phenobarbital on Hepatic Transport and Excretion of 131I-Rose Bengal in Children with Cholestasis

1972 • 35 citations

Hepatic transport of mono and bisquaternary ammonium compounds

1970 • 35 citations

Effect of spironolactone, pregnenolone-16 -carbonitrile and cortisol on the metabolism and biliary excretion of sulfobromophthalein and phenol-3,6-dibromophthalein disulfonate in rats.

1972 • 35 citations

Biliary excretion of barbiturates

1971 • 35 citations

Effect of theophylline of hepatic excretory function

1974 • 33 citations

Biliary Excretion and Intestinal Reabsorption of Mercury in the Rat after Injection of Methyl Mercuric Cloride

1973 • 33 citations

Enterohepatic circulation of 64Cu, 52Mn and 203Hg in rats

1973 • 33 citations

CIRCULAR DICHROISM STUDIES OF Y PROTEIN (LIGANDIN), A MAJOR ORGANIC ANION BINDING PROTEIN IN LIVER, KIDNEY, AND SMALL INTESTINE*

1973 • 32 citations

Human Bile Proteins

1962 • 30 citations

270 MHz proton magnetic resonance spectra of metallothionein

1974 • 30 citations

Hepatic transport of organic cations: Active uptake of a quaternary ammonium compound, procaine amide ethobromide, by rat liver slices

1963 • 30 citations

The Effect of Chelating Agents on Biliary Excretion of Methyl Mercuric Salts in the Rat

1973 • 29 citations

Species variation in the biliary excretion of ouabain.

1972 • 28 citations

Distribution of quaternary ammonium compounds between particulate and soluble constituents of rat liver, in relation to their transport from plasma into bile

1972 • 25 citations

Active transport of tertiary amine compounds into bile

1969 • 25 citations

Studies on Zinc Absorption: 65Zn Binding by Homogenates of Rat Intestinal Mucosa

1971 • 24 citations

Biliary Excretion of Chelated Iron.

1965 • 24 citations

Evidence for the existence of a carrier for bromosulphonphthalein in the liver cell plasma membrane

1974 • 23 citations

Effect of Alteration in Body Temperature on the Biliary Excretion of Copper

1973 • 23 citations

Biliary Copper Excretion in the Rat

1971 • 22 citations

The initial uptake of copper by the liver in the dog

1968 • 22 citations

The Binding of Copper by Bile and Serum

1971 • 22 citations

Biliary Excretion of Mercury Enhanced by Spironolactone

1972 • 21 citations

Inhibition of ouabain-H3 uptake by liver slices and its excretion into the bile and by compounds having a steroid nucleus

1969 • 21 citations

The excretion and biologic decay rates of Cd115m with a consideration of space, mass, and distribution in dogs.

1959 • 20 citations

Uptake and Biliary Excretion of Cu64 in Rabbits in Relation to Blood Ceruloplasmin.

1965 • 20 citations

Biliary iron excretion in normal and iron-loaded rats after desferrioxamine and CaDTPA

1968 • 20 citations

The effect of phenobarbital and sodium dehydrocholate on the biliary excretion of methylmercury in the rat

1974 • 20 citations

PHENOBARBITONE ENHANCEMENT OF BROMSULPHALEIN CLEARANCE IN NEONATAL HYPERBILIRUBINEMIA

1971 • 19 citations

The cardiac glycoside sensitive step in the hepatic transport of the bisquaternary ammonium compound, hexafluorenium

1971 • 19 citations

Tissue distribution studies of ionic and chelated Zn65 in mice.

1962 • 19 citations

Active transport of chlorothiazide into bile

1966 • 18 citations

Release of copper by rat liver

1970 • 18 citations

Excretion of Lead in the Bile

1946 • 17 citations

Impaired hepatic disposition of sulfobromophthalein sodium in neonatal guinea pigs: nature of the defect.

1970 • 15 citations

Increased Stool Mercury Excretion in the Rat: The Effect of Spironolactone

1972 • 15 citations

Biliary excretion of phenyl- and methyl mercury chlorides and their enterohepatic circulation in rats

1974 • 13 citations

Excretion of Intravenously Injected Solid Particles in Bile

1960 • 12 citations

RADIOPHARMACOLOGICAL STUDIES ON THE CADMIUM POISONING

1972 • 12 citations

The passage of serum albumin into bile in man

1965 • 11 citations

Rapid passage of mannitol into liver and bile

1970 • 11 citations

Manganese binding in rat bile

1973 • 11 citations

Effect of Phenobarbitone on the Biliary Excretion of Methylmercury in Rats and Mice

1973 • 10 citations

Depression of biliary excretion of infused bilirubin in rats and guinea pigs by bile

1971 • 10 citations

Effects of phenobarbital treatment on biliary excretion in man.

1973 • 10 citations

Transport and Binding of Chloroguanide-Triazine by Rat Liver Slices

1969 • 9 citations

Species Difference in the Plasma Disappearance and Biliary Excretion of Procaine Amide Ethobromide

1972 • 8 citations