Pathophysiological Mechanisms of Brain Damage from Status Epilepticus

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

A Family of AMPA-Selective Glutamate Receptors

1990 • 1,453 citations

EPILEPSY AND THE TEMPORAL LOBES

1966 • 1,256 citations

Mossy fiber synaptic reorganization in the epileptic human temporal lobe

1989 • 1,150 citations

Greenfield's Neuropathology

1985 • 1,149 citations

Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study

1983 • 1,082 citations

Decreased Hippocampal Inhibition and a Selective Loss of Interneurons in Experimental Epilepsy

1987 • 1,077 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

Cloning by functional expression of a member of the glutamate receptor family

1989 • 1,009 citations

Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes

1990 • 925 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

Neonatal Seizures

1990 • 764 citations

Kainic acid: a powerful neurotoxic analogue of glutamate

1974 • 710 citations

Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The “dormant basket cell” hypothesis and its possible relevance to temporal lobe epilepsy

1991 • 706 citations

Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study

1980 • 700 citations

Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates

1981 • 683 citations

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

1991 • 638 citations

The role of calcium in cell death

1981 • 637 citations

Extracellular free calcium and potassium during paroxysmal activity in the cerebral cortex of the cat

1977 • 636 citations

Regulation of growth cone behavior by calcium

1991 • 597 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

“Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies

1983 • 554 citations

Prolonged Epileptic Seizures in Primates

1973 • 531 citations

Brain Microdialysis

1989 • 518 citations

Status epilepticus

1980 • 468 citations

2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation

1981 • 468 citations

Neurotoxicity ofN-methyl-d-aspartate is markedly enhanced in developing rat central nervous system

1988 • 465 citations

Low Morbidity and Mortality of Status Epilepticus in Children

1989 • 462 citations

Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells

1991 • 461 citations

Erkrankung des Ammonshorns als aetiologisches Moment der Epilepsie

1880 • 453 citations

Systemic Factors and Epileptic Brain Damage

1973 • 440 citations

The role of epileptic activity in hippocampal and ‘remote’ cerebral lesions induced by kainic acid

1980 • 428 citations

Epilepsy and Neuron Loss in the Hippocampus

1980 • 422 citations

Convulsive Status Epilepticus in Infants and Children

1970 • 417 citations

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

1971 • 409 citations

Electrophysiology of Epilepsy

1985 • 392 citations

The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures

1987 • 379 citations

Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus

1989 • 372 citations

Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated Rats

1983 • 364 citations

Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae

1984 • 355 citations

Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations

1990 • 343 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

Physiology of Status Epilepticus in Primates

1973 • 329 citations

Cerebral Metabolic and Circulatory Responses to Induced Convulsions in Animals

1968 • 325 citations

CEREBRAL METABOLIC CHANGES DURING PROLONGED EPILEPTIC SEIZURES IN RATS

1977 • 316 citations

Status epilepticus in well–oxygenated rats causes neuronal necrosis

1985 • 312 citations

Intelligence in epilepsy: A prospective study in children

1983 • 307 citations

Acute dendrotoxic changes in the hippocampus of kainate treated rats

1979 • 306 citations

Coupling between neurons of the developing rat neocortex

1983 • 306 citations

CEREBRAL BLOOD FLOW AND METABOLIC RATE EARLY AND LATE IN PROLONGED EPILEPTIC SEIZURES INDUCED IN RATS BY BICUCULLINE

1976 • 296 citations

Non-NMDA receptor-mediated neurotoxicity in cortical culture

1990 • 291 citations

The Neuropathology of Temporal Lobe Epilepsy

1989 • 283 citations

The Calcium Channel Blocker Nifedipine Attenuates Slow Excitatory Amino Acid Neurotoxicity

1990 • 271 citations

Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury

1991 • 265 citations

KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS

1979 • 260 citations

“Epileptic” brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine

1985 • 242 citations

Acid-induced death in neurons and glia

1991 • 241 citations

Hydrogen Ions Kill Brain at Concentrations Reached in Ischemia

1987 • 237 citations

Ontogenetic development of kainate neurotoxicity: correlates with glutamatergic innervation.

1978 • 236 citations

EFFECTS OF SODIUM GLUTAMATE ON THE NERVOUS SYSTEM

1954 • 235 citations

Abnormal Neuronal Discharges

1979 • 235 citations

Dantrolene Prevents Glutamate Cytotoxicity and Ca²⁺ Release from Intracellular Stores in Cultured Cerebral Cortical Neurons

1991 • 232 citations

CEREBRAL ENERGY METABOLISM DURING EXPERIMENTAL STATUS EPILEPTICUS¹

1975 • 218 citations

Ketamine, Phencyclidine, and MK‐801 Protect Against Kainic Acid‐Induced Seizure‐Related Brain Damage

1990 • 217 citations

Dopamine Synaptic Mechanisms Reflected in Studies Combining Behavioural Recordings and Brain Dialysis

1982 • 210 citations

Die Pathogenese des epileptischen Krampfes

1927 • 208 citations

Direct Evidence That Excitotoxicity in Cultured Neurons Is Mediated via N‐Methyl‐D‐Aspartate (NMDA) as well as Non‐NMDA Receptors

1989 • 208 citations

Maturation of kainic acid seizure-brain damage syndrome in the rat. i. clinical, electrographic and metabolic observations

1984 • 207 citations

Epileptic Brain Damage: The Role of Systemic Factors That Modify Cerebral Energy Metabolism

1978 • 202 citations

Metabolic factors during prolonged seizures and their relation to nerve cell death.

1983 • 192 citations

Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra.

1985 • 191 citations

Autonomic Dysfunction in Epilepsy: Characterization of Autonomic Cardiac Neural Discharge Associated with Pentylenetetrazol‐Induced Epileptogenic Activity

1982 • 186 citations

Basic mechanisms of the epilepsies: Molecular and cellular approaches

1987 • 186 citations

Seizure-related brain damage induced by cholinergic agents

1983 • 186 citations

Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat

1989 • 179 citations

Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain

1990 • 175 citations

Focal Cortical Seizures Cause Distant Thalamic Lesions

1982 • 172 citations

“Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology

1983 • 170 citations

Intracellular calcium accumulation in rat hippocampus during seizures induced by bicuculline orl-allylglycine

1983 • 168 citations

Chapter 27 Chapter Seizures, neuropeptide regulation, and mRNA expression in the hippocampus

1990 • 166 citations

Neuropathology of status epilepticus in humans.

1983 • 166 citations

The significance of MRI abnormalities in children with neurofibromatosis

1989 • 160 citations

Status Epilepticus: Mechanisms of Brain Damage and Treatment

1984 • 160 citations

Role of electrical interactions in synchronization of epileptiform bursts.

1986 • 158 citations

Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices

1986 • 153 citations

Convulsive Disorders in the First Year of Life: Neurological and Mental Outcome and Mortality

1978 • 153 citations

A new model of partial status epilepticus based on kindling

1982 • 152 citations

Changes in Extracellular Amino Acids During Soman‐and Kainic Acid‐Induced Seizures

1987 • 146 citations

Metabolic Changes in Cerebral Cortex, Hippocampus, and Cerebellum During Sustained Bicuculline‐Induced Seizures

1981 • 144 citations

The pattern of 72-kDa heat shock protein-like immunoreactivity in the rat brain following flurothyl-induced status epilepticus

1990 • 139 citations

Effects of neonatal status epilepticus on rat brain development

1976 • 139 citations

Local blood flow and glucose consumption in the rat brain during sustained bicuculline-induced seizures

1983 • 138 citations

INTELLECTUAL FUNCTIONS OF PATIENTS WITH CHILDHOOD‐ONSET EPILEPSY

1986 • 136 citations

Hippocampal damage produced by systemic injections of domoic acid in mice

1991 • 135 citations

Potentiation of kainic acid epileptogenicity and sparing from neuronal damage by an NMDA receptor antagonist

1989 • 134 citations

Inositol polyphosphates and neuronal calcium homeostasis

1988 • 133 citations

Status epilepticus: The reversibility of calcium loading and acute neuronal pathological changes in the rat hippocampus

1984 • 130 citations

Cerebral Metabolism During Electrically Induced Seizures in Man

1969 • 130 citations

Regulation of Glycolysis in Brain, in Situ, during Convulsions

1966 • 123 citations

The Neuropathology of Status Epilepticus

1964 • 120 citations

Effects of status epilepticus on extracellular amino acids in the hippocampus

1985 • 118 citations

Drugs, Coma, and Myoglobinuria

1972 • 116 citations

The non-NMDA receptors: types, protein structure and molecular biology

1990 • 115 citations

Cerebral metabolic effects of neonatal seizures measured with in vivo ³¹P NMR spectroscopy

1986 • 112 citations

Consequences of status epilepticus in infants and children.

1983 • 110 citations

Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents

1989 • 109 citations

Cellular and Extracellular Spaces in Developing Rat Brain

1965 • 108 citations

The Contribution of Patho‐Anatomical Research to the Problem of Epilepsy

1959 • 99 citations

Excitatory Transmitters and Epilepsy-Related Brain Damage

1985 • 95 citations

Maturation of kainic acid seizure-brain damage syndrome in the rat. III. Postnatal development of kainic acid binding sites in the limbic system

1984 • 95 citations

Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures

1989 • 95 citations

Neurotransmitters and Epilepsy

1987 • 94 citations

Basic mechanisms of the epilepsies. Molecular and cellular approaches.

1986 • 93 citations

Mortality and Morbidity from Serial Seizures

1974 • 92 citations

Behavioral Effects of Kainic Acid Administration on the Immature Brain

1988 • 86 citations

Status epilepticus, mechanisms of brain damage and treatment

1983 • 82 citations

Extracellular K+ and Ca2+ changes during epileptiform discharges in the immature rat neocortex

1987 • 81 citations

³¹P NMR study of cerebral metabolism during prolonged seizures in the neonatal dog

1985 • 78 citations

Brain glucose metabolism in the newborn rat

1971 • 74 citations

Dictionary of epilepsy

1973 • 70 citations

Glutamate recognition sites in human fetal brain

1988 • 69 citations

Generalized seizures deplete brain energy reserves in normoxemic newborn monkeys

1988 • 68 citations

Brain Damage after Febrile Convulsions

1957 • 68 citations

Alterations in hippocampal extracellular amino acids and purine catabolites during limbic seizures induced by folate injections into the rabbit amygdala

1987 • 64 citations

Effects of bicuculline‐induced seizures on cerebral metabolism and circulation of rats rendered hypoglycemic by starvation

1979 • 56 citations

Convulsant and anticonvulsant drug binding sites related to GABA-regulated chloride ion channels.

1981 • 56 citations

Metabolic Alterations Underlying the Development of Hypermetabolic Necrosis in the Substantia Nigra in Status Epilepticus

1987 • 55 citations

[3H]MK-801 binding sites in neonate rat brain

1989 • 55 citations

Brain glucose metabolism in the intact mouse

1971 • 53 citations

Elevated pulmonary lymph flow and protein content during status epilepticus in sheep

1982 • 52 citations

Status Epilepticus in Immature Rats

1976 • 50 citations

Neurotransmitters and Epilepsy

1992 • 50 citations

Local cerebral glucose utilization during status epilepticus in newborn primates

1989 • 49 citations

Abnormal neuronal discharges

1978 • 47 citations

Electroconvulsive seizures in the immature rat adversely affect myelin accumulation

1982 • 43 citations

Effects of d-(−)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid

1988 • 43 citations

Problems and Concepts in Developmental Neurophysiology

1990 • 42 citations

Development of high affinity kainate binding sites in human and rat hippocampi

1986 • 40 citations

Interstitial Fluid Adenosine and Sagittal Sinus Blood Flow during Bicuculline-Seizures in Newborn Piglets

1987 • 37 citations

Cerebral oxygenation during recurrent seizures.

1983 • 37 citations

Status epilepticus facilitated by pilocarpine in amygdala-kindled rats

1986 • 37 citations

Synaptic Proteins After Electroconvulsive Seizures in Immature Rats

1980 • 34 citations

Positron emission tomography in the newborn

1985 • 33 citations

Decreased calmodulin kinase activity after status epilepticus

1988 • 33 citations

Cerebral energy metabolism during experimental status epilepticus.

1983 • 33 citations

Status epilepticus following stimulation of a kindled hippocampal focus in intact and commissurotomized rats

1986 • 31 citations

Brain protein metabolism in epilepsy.

1986 • 30 citations

Regional calcium accumulation and kainic acid (KA)-induced limbic seizure status in rats

1989 • 30 citations

Endocrine Factors and Glucose Metabolism During Prolonged Seizures in Baboons

1979 • 29 citations

Preferential blood flow to brainstem during generalized seizures in the newborn marmoset monkey

1986 • 28 citations

Neonatal Seizures in Monkeys and Rabbits: Brain Glucose Depletion in the Face of Normoglycemia, Prevention by Glucose Loads

1985 • 28 citations

Regional Cerebral Blood Flow during Bicuculline-Induced Seizures in the Newborn Piglet: Effect of Phenobarbital

1985 • 27 citations

Mechanisms underlying interictal-ictal transitions.

1983 • 26 citations

Problems and concepts in developmental neurophysiology

1989 • 25 citations

Amplifying Effects of Several Vasoconstrictor Agents of αi-Adrenoceptor-Mediated Contraction of Isolated Thoracic Aortae of the Guinea Pig

1989 • 23 citations

Medical complications of status epilepticus.

1983 • 23 citations

Complex Partial Status Epilepticus

1988 • 22 citations

Regional cerebral blood flow pattern in subcortical propagation of focal seizures in newborn monkeys

1977 • 22 citations

Nonconvulsive status epilepticus in childhood: clinical aspects and classification.

1983 • 22 citations

Cyclic nucleotide metabolism in mouse brain during seizures induced by bicuculline or dibutyryl cyclic guanosine monophosphate

1980 • 21 citations

Low [³H]Cytochalasin B Binding in the Cerebral Cortex of Newborn Rat

1988 • 19 citations

Selective focal inhibition of brain protein synthesis during generalized bicuculline seizures in newborn marmoset monkeys

1984 • 17 citations

Free arachidonic acid and membrane lipids in the central nervous system during bicuculline-induced status epilepticus.

1983 • 14 citations

Status Epilepticus

1981 • 3 citations

Role of receptors for neurotransmitters in status epilepticus.

1983 • 2 citations