Ever since Knudson

The Hallmarks of Cancer

2000 • 27,569 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Systematic variation in gene expression patterns in human cancer cell lines

2000 • 2,119 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

2000 • 1,182 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1998 • 796 citations

Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

2001 • 770 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

A Mutator Phenotype in Cancer 1

2001 • 675 citations

Evolution of neoplastic cell lineages in Barrett oesophagus

1999 • 448 citations

Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer

2000 • 446 citations

DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours

1997 • 444 citations

TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer

2001 • 438 citations

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.

2000 • 400 citations

In vivo gene expression profile analysis of human breast cancer progression.

1999 • 396 citations

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1999 • 373 citations

E-cadherin gene mutations in human gastric carcinomacell lines.

1994 • 288 citations

Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia.

2001 • 284 citations

Identification of Germline and Somatic Mutations Affecting the Retinoblastoma Gene

1988 • 270 citations

Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype.

1997 • 254 citations

Mechanisms underlying losses of heterozygosity in human colorectal cancers

2001 • 221 citations

The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum.

1997 • 158 citations

Tumour-suppressor genes: evolving definitions in the genomic age

1997 • 148 citations

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33

1998 • 128 citations

High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination.

1997 • 120 citations

Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1

1999 • 119 citations

Loss of Heterozygosity or: How I Learned to Stop Worrying and Love Mitotic Recombination

1997 • 119 citations

Mitotic recombination map of 13cen–13q14 derived from an investigation of loss of heterozygosity in retinoblastomas

1999 • 116 citations

Accommodating haploinsufficient tumour suppressor genes in Knudson's model

2000 • 109 citations

Loss of heterozygosity mapping at chromosome arm 16q in 712 breast tumors reveals factors that influence delineation of candidate regions.

2001 • 108 citations

Near-Haploidy and Subsequent Polyploidization Characterize the Progression of Peripheral Chondrosarcoma

2000 • 70 citations

Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro

1998 • 52 citations

On the statistical analysis of allelic-loss data

1998 • 46 citations

Allelotype analysis of flow-sorted breast cancer cells demonstrates genetically related diploid and aneuploid subpopulations in primary tumors and lymph node metastases

2000 • 43 citations

Fractional allelic imbalance in human breast cancer increases with tetraploidization and chromosome loss

1992 • 42 citations

Loss of Heterozygosity and Base Substitution at the APRT Locus in Mismatch-Repair-Proficient and -Deficient Colorectal Carcinoma Cell Lines

1996 • 32 citations

Loss of heterozygosity at 7q31 in breast cancer: results from an International Collaborative Study Group. The Breast Cancer Somatic Genetics Consortium.

1997 • 25 citations