Selective changes in mu opioid receptor properties induced by chronic morphine exposure.

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

1987 • 260 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

Pertussis toxin blocks the outward currents evoked by opiate and α2-agonists in locus coeruleus neurons

1986 • 241 citations

Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes.

1983 • 211 citations

Narcotic Receptor Sites in Morphine-dependent Rats

1974 • 201 citations

Morphine‐tolerant longitudinal muscle strip from guinea‐pig ileum

1973 • 155 citations

Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment.

1987 • 122 citations

Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus.

1984 • 121 citations

Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: a useful model for the study of tolerance at mu opioid receptors.

1988 • 119 citations

Comparison of in vivo and in vitro parameters of opiate receptor binding in naive and tolerant/dependent rodents

1975 • 108 citations

Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.

1986 • 85 citations

Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.

1988 • 78 citations

Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures

1987 • 67 citations

Morphine-induced opioid receptor down-regulation detected in intact adult rat brain cells

1986 • 62 citations

Lack of cross-tolerance on multiple opiate receptors in the mouse vas deferens.

1980 • 62 citations

Differentiation of opiate receptors in the brain by the selective development of tolerance

1981 • 47 citations

The physiological relevance of low agonist affinity binding at opioid μ‐receptors

1988 • 40 citations

The effect of N-allylnormorphine upon the development of tolerance to morphine in the albino rat.

1953 • 34 citations

Opioid ligand binding sites in the spinal cord of the guinea-pig

1986 • 32 citations

Selective tolerance at mu and kappa opioid receptors modulating norepinephrine release in guinea pig cortex.

1988 • 24 citations

Intact brain cells: A novel model system for studying opioid receptor binding

1985 • 10 citations

Naloxone prevention of morphine LDR curve flattening associated with high-dose tolerance

1981 • 5 citations

Cited By (0)

Loading...